concept

DOPAMINERGIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOPAMINERGIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1443Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

8Experiments

0Debates

Summary

DOPAMINERGIC is a concept in neurodegeneration research. Key relationships include: co discussed, causes, regulates. Associated with NEURODEGENERATION, PARKINSON, PARKINSON'S. Connected to 145 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DOPAMINERGIC
Key Genes/Proteins	ACHE, ACTB, AD, AIF1, AKT, Alpha-Synuclein
Related Diseases	aging, Alzheimer'S Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Continuous Dopaminergic Stimulation for Parkinson's Disease

company · 523 words

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Pathway Diagram

graph TD
    DOPAMINERGIC["DOPAMINERGIC"]
    DOPAMINERGIC -->|"causes"| NEURON["NEURON"]
    DOPAMINERGIC -->|"causes"| NEURONS["NEURONS"]
    DOPAMINERGIC -->|"causes"| SENESCENCE["SENESCENCE"]
    DOPAMINERGIC -->|"causes"| PARKIN["PARKIN"]
    DOPAMINERGIC -->|"causes"| PARKINSON["PARKINSON"]
    DOPAMINERGIC -->|"causes"| PARKINSON_S["PARKINSON'S"]
    DOPAMINERGIC -->|"causes"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    DOPAMINERGIC -->|"causes"| SUBSTANTIA_NIGRA["SUBSTANTIA NIGRA"]
    DOPAMINERGIC -->|"regulates"| PI3K["PI3K"]
    AKT["AKT"] -->|"regulates"| DOPAMINERGIC
    ASTROCYTE["ASTROCYTE"] -->|"interacts"| DOPAMINERGIC
    ASTROCYTES["ASTROCYTES"] -->|"interacts"| DOPAMINERGIC
    COMPLEMENT["COMPLEMENT"] -->|"activates"| DOPAMINERGIC
    APOPTOSIS["APOPTOSIS"] -->|"causes"| DOPAMINERGIC
    AMPK["AMPK"] -->|"activates"| DOPAMINERGIC
    AUTOPHAGY["AUTOPHAGY"] -->|"promotes"| DOPAMINERGIC

Outgoing (538)

Target	Relation	Type	Str
MICROGLIA	expresses	cell_type	0.70
LRRK2	associated_with	gene	0.70
JAK	inhibits	gene	0.70
NEURONS	enhances	cell_type	0.70
WNT	activates	gene	0.70
MOTOR NEURON	expresses	cell_type	0.70
PINK1	activates	gene	0.70
TFEB	activates	gene	0.70
PINK1	associated_with	gene	0.70
MICROGLIA	disrupts	cell_type	0.70
PLA2G6	associated_with	gene	0.70
VPS35	associated_with	gene	0.70
JAK	activates	gene	0.70
PARK7	associated_with	gene	0.70
TFEB	causes	gene	0.70
MICROGLIA	causes	cell_type	0.70
FBXO7	associated_with	gene	0.70
WNT	causes	gene	0.70
GBA	protects_against	gene	0.70
SYNJ1	associated_with	gene	0.70
NEURONS	stabilizes	cell_type	0.70
TFEB	associated_with	gene	0.70
GLUTAMATERGIC	inhibits	cell_type	0.70
NEURONS	markers	cell_type	0.70
LRRK2	inhibits	gene	0.70
HTR2A	regulates	gene	0.70
TREM2	disrupts	gene	0.70
STING	expresses	gene	0.70
STING	associated_with	gene	0.70
DRD2	activates	gene	0.70
SLC6A4	regulates	gene	0.70
NOTCH	transports	gene	0.70
GBA	expresses	gene	0.70
NEURONS	disrupts	cell_type	0.70
NECROPTOSIS	protects_against	pathway	0.70
RAGE	interacts_with	gene	0.70
TNF	activates	gene	0.70
MICROGLIA	mediates	cell_type	0.70
NECROPTOSIS	activates	pathway	0.70
MLKL	activates	gene	0.70
PINK1	interacts_with	gene	0.70
STING	activates	gene	0.70
DRD2	inhibits	gene	0.70
SNCA	markers	gene	0.70
GLUTAMATERGIC	activates	cell_type	0.70
SNCA	activates	gene	0.70
DRD2	regulates	gene	0.70
MAPT	activates	gene	0.70
PLP1	activates	gene	0.70
GABAERGIC	activates	cell_type	0.70

Incoming (905)

Source	Relation	Type	Str
ATP13A2	associated_with	gene	0.70
CHRNA7	regulates	gene	0.70
BDNF	expresses	gene	0.70
ATG5	mediates	gene	0.70
ACHE	regulates	gene	0.70
BDNF	markers	gene	0.70
COMT	regulates	gene	0.70
CYP46A1	inhibits	gene	0.70
AQP4	causes	gene	0.65
BECN1	associated_with	gene	0.65
CASP1	associated_with	gene	0.65
AIF1	associated_with	gene	0.65
ATG7	associated_with	gene	0.65
ATG5	associated_with	gene	0.65
CYTOKINES	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
CD4	regulates	gene	0.60
AMPK	activates	gene	0.60
HUNTINGTON	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
TUBB3	regulates	gene	0.60
NDUFA9	regulates	gene	0.60
ASTROCYTES	interacts_with	cell_type	0.60
ASTROCYTE	interacts_with	gene	0.60
GCASE	causes	gene	0.60
NEURON	causes	gene	0.60
PLIN2	causes	gene	0.60
GBA	causes	gene	0.60
AGING	causes	gene	0.60
SLC6A3	regulates	gene	0.60
SNCA	inhibits	gene	0.60
TUBB	regulates	gene	0.60
ASTROCYTE	interacts_with	cell_type	0.60
ALZHEIMER	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
TUBB4B	regulates	gene	0.60
GFP	associated_with	gene	0.60
SNCA	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
ACTB	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
NLR	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.740	neuroscience	Circuit-level neural dynamics in neurode
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.606	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plasma ATN biomarkers across AD continuum in Chilean cohort	clinical	Alzheimer's disease	0.950	Chilean older adults (n=318) w	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Differential GWAS of schizophrenia vs PTSD	exploratory	schizophrenia, post-traumatic	0.900	human patients - European ance	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Creation and validation of 3xAD-ChAT-Cre mouse model	validation	Alzheimer's disease	0.900	3xAD-ChAT-Cre transgenic mice	proposed	N/A
GTEx brain tissue expression analysis of MAPT/CRHR1 locus	exploratory	schizophrenia, post-traumatic	0.850	human brain tissue samples fro	proposed	N/A
Microtubule domain analysis in adult axons	exploratory		0.800	adult rodent axons	proposed	N/A
Tau depletion effects on microtubule domains in adult axons	exploratory		0.800	adult rodent neurons	proposed	N/A

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128]	["Bolsewig K", "Bellomo G", "Hok-A-Hin Y	Nature medicine	2026
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147]	["Bolsewig K", "Willemse E", "S\u00e1nch	Nature communications	2025
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958]	["Montillot C", "Skutunova E", "Ayushma"	Neurobiology of disease	2023
Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274]	["Motta C", "Assogna M", "Bonomi C", "Di	European journal of neurology	2023
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020
DOPA Decarboxylase Modulates Tau Toxicity. [PMID:28751068]	["Kow R", "Sikkema C", "Wheeler J", "Wil	Biological psychiatry	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity