protein

NLRP3 INFLAMMASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP3 INFLAMMASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

874Connections

11Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

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🔬 Protein Info

Gene Symbol	NLRP3 INFLAMMASOME
CRID3	early selective inhibitor
MCC994	optimized analog
Associated Diseases	AGING, Alzheimer's Disease, APOPTOSIS, ATP, AUTISM
Known Drugs/Compounds	BERBERINE, EMPAGLIFLOZIN, FINGOLIMOD, FISETIN, MELATONIN, METFORMIN
Interactions	HSP90A, NAMO
KG Connections	344 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NLRP3 Inflammasome

entity · 1114 words

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Pathway Diagram

graph TD
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"activates"| Microglia["Microglia"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| IL_1_["IL-1Beta"]
    style IL_1_ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Inflammatory_Diseases["Inflammatory Diseases"]
    style Inflammatory_Diseases fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Glaucoma["Glaucoma"]
    style Glaucoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Retinal_Ganglion_Cell_Death["Retinal Ganglion Cell Death"]
    style Retinal_Ganglion_Cell_Death fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP22["USP22"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP22 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    USP5["USP5"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF__B["NF-kappaB"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style NF__B fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style __SYNUCLEIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Macrophage["Macrophage"] -->|"expressed in"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style Macrophage fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style NLRP3_INFLAMMASOME fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (303)

Target	Relation	Type	Str
pyroptosis	mediates	process	0.96
Retinal Ganglion Cell Death	contributes_to	phenotype	0.95
Neuroinflammation	contributes_to	process	0.95
IL18	associated_with	protein	0.95
Microglia	activates	cell_type	0.95
Pyroptosis	mediates	process	0.95
Retinal Ganglion Cell Death	mediates	process	0.95
Caspase-1 Activation	activates	mechanism	0.93
IL1B	upregulates	gene	0.92
Alzheimer's disease	associated_with	disease	0.92
dementia progression	promotes	phenotype	0.92
Alzheimer's Disease	associated_with	disease	0.90
Neuroinflammation	activates	process	0.90
Neuroinflammation	mediates	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
Inflammatory Diseases	involved_in	disease	0.90
Inflammatory Diseases	involved_in	disease	0.90
neuroinflammation	drives	process	0.90
GSDMD	activates	protein	0.90
pathological inflammation	promotes	process	0.90
IL18	upregulates	protein	0.90
IL1B	upregulates	protein	0.90
Caspase-1 Activation	activates	process	0.90
Phagocytic Function	inhibits	process	0.90
Neuroinflammation	causes	process	0.90
Neuroinflammation	causes	process	0.90
Pyroptosis	activates	process	0.90
Glaucoma	involved_in	disease	0.90
Retinal Ganglion Cell Death	causes	phenotype	0.90
IL-1Β	associated_with	protein	0.90
IL-18	associated_with	protein	0.90
Neuroinflammation	activates	process	0.90
Pyroptosis	associated_with	process	0.90
neointima formation	promotes	process	0.90
Liver inflammation	contributes_to	process	0.90
IL-1Β	associated_with	protein	0.90
Inflammatory Diseases	involved_in	disease	0.90
AUTOPHAGY	inhibited_by	process	0.90
neuroinflammation	promotes	process	0.90
Microglia	activates	cell_type	0.90
CASP1	activates	protein	0.88
IL1B	activates	protein	0.88
Neurodegeneration	contributes_to	phenotype	0.88
Microglial Phagocytic Function	inhibits	process	0.88
cognitive decline	promotes	phenotype	0.88
IL-1β	upregulates	protein	0.88
Neuroinflammation	mediates	process	0.88
Preeclampsia	contributes_to	disease	0.88
IL1B	activates	gene	0.85
tissue damage	causes	phenotype	0.85

Incoming (571)

Source	Relation	Type	Str
Ciliatoside A	inhibits	compound	0.95
REV-ERBα	inhibits	protein	0.95
Polygala Saponins	inhibits	compound	0.95
Pg OMVs	activates	compound	0.95
USP9X	regulates	gene	0.95
Usp9X Suppression	inhibits	mechanism	0.95
ZFP36	inhibits	gene	0.95
Tlr2 Inhibition	suppresses	mechanism	0.95
HDAC3	promotes	gene	0.95
Kaempferol	inhibits	compound	0.95
Neutrophil Extracellular Traps	activates	process	0.95
TLR2	activates	gene	0.95
Carnosic Acid	inhibits	compound	0.95
small-molecule inhibitors	inhibits	drug	0.95
GS-1	suppresses	compound	0.95
NLRP3	component_of	protein	0.95
NLRP3	involved_in	protein	0.95
A20	inhibits	protein	0.93
NEK7	activates	protein	0.92
Ruxolitinib	inhibits	drug	0.92
GS-1	inhibits	compound	0.92
AMPK	inhibits	protein	0.90
Mitophagy	inhibits	process	0.90
NLRP3	part_of	gene	0.90
HSP90A	activates	gene	0.90
Young plasma	modulates	compound	0.90
CLEC16A	inhibits	gene	0.90
Donepezil	associated_with	drug	0.90
TFEB	inhibits	protein	0.90
Baohuoside I	inhibits	drug	0.90
SMPD1	activates	gene	0.90
SEVOFLURANE	activates	compound	0.90
USP5	attenuates	gene	0.90
LCN2	activates	protein	0.90
Mitochondrial Damage	activates	process	0.88
Biomechanical Strain	activates	process	0.88
autophagy-lysosomal pathway	downstream_of	pathway	0.88
Frostbite Injury	upregulates	disease	0.88
Biomechanical Strain	activates	process	0.88
CB13	inhibits	drug	0.87
GPER	inhibits	protein	0.87
NF-κB	activates	pathway	0.87
CMPK2	activates	gene	0.85
Α-SYNUCLEIN	activates	protein	0.85
Microglia	associated_with	cell_type	0.85
Macrophage	expressed_in	cell_type	0.85
PARKIN	regulates	gene	0.85
MCC950	inhibits	drug	0.85
STAT3	regulates	protein	0.85
macroautophagy	inhibits	process	0.85

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
NLRP3 Inflammasome Lock Perpetuates Senescence-Associated In	0.720	neurodegeneration	What molecular mechanisms drive microgli
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.650	neuroscience	Lysosomal dysfunction and cathepsin leak
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.640	neuroinflammation	What are the specific molecular mechanis
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak

Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP	0.590	neurodegeneration	What are the optimal oxygen pressure, du
NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumul	0.566	developmental neurobiology	Do perinatal immune challenges create pe
NLRP3 Inflammasome Blockade as Upstream Intervention to Prev	0.566	neurodegeneration	Why have numerous phase 3 clinical trial
P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming	0.560	biomarkers	What biomarkers can reliably detect micr
TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inf	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Molecular characterization of RBG-NLRP3 binding interaction	exploratory	atherosclerosis	0.900	purified proteins and molecula	proposed	N/A
Leukocyte gene expression analysis in COVID-19 patients	exploratory	COVID-19	0.900	human leukocytes from COVID-19	proposed	N/A
RBG effects on macrophage polarization and foam cell formation	exploratory	atherosclerosis	0.850	primary macrophages	proposed	N/A
Transcriptomic analysis of RBG effects on inflammatory gene expression	exploratory	atherosclerosis	0.800	ApoE-/- mice and cell cultures	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning NLRP3 INFLAMMASOME in their description or question text

Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP3 inflammasome and s

Score: 0.590 · neurodegeneration · 2026-04-25

This hypothesis proposes that HBOT reduces ROS-mediated NF-κB activation and NLRP3 inflammasome assembly, promoting anti

NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation

Score: 0.566 · developmental neurobiology · 2026-04-21

## Mechanistic Overview NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation starts from the claim that mod

NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplificati

Score: 0.566 · neurodegeneration · 2026-04-16

## Mechanistic Overview NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplification starts from t

P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming

Score: 0.560 · biomarkers · 2026-04-22

## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin

TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation

Score: 0.485 · Neuroinflammation · 2026-04-21

## Mechanistic Overview TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation starts from the

NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition

Score: 0.105 · neurodegeneration · 2026-04-18

## Mechanistic Overview NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition starts from the claim that mod