concept

T CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2399Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

11Experiments

0Debates

Summary

T CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, associated with. Associated with ALZHEIMER'S DISEASE, CANCER, ENCEPHALITIS. Connected to 200 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	T CELL
Key Genes/Proteins	ACHE, AKT, AMPK, AMYLOID
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Pathway Diagram

graph TD
    T_CELL["T CELL"]
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| T_CELL
    HSPG2["HSPG2"] -->|"expressed in"| T_CELL
    CANCER["CANCER"] -->|"expressed in"| T_CELL
    TCR["TCR"] -->|"expressed in"| T_CELL
    CD40["CD40"] -->|"expressed in"| T_CELL
    AQP4["AQP4"] -->|"expressed in"| T_CELL
    HSPA1A["HSPA1A"] -->|"expressed in"| T_CELL
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| T_CELL
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| T_CELL
    HSP70["HSP70"] -->|"expressed in"| T_CELL

Outgoing (134)

Target	Relation	Type	Str
Lewy Body Dementia	involved_in	disease	0.90
Dopaminergic Neuron	interacts_with	cell_type	0.85
Brain Homing	involved_in	process	0.85
tumor immune microenvironment	expressed_in	pathway	0.85
Amyotrophic Lateral Sclerosis	involved_in	disease	0.80
TAU	activates	gene	0.65
TAU	interacts_with	gene	0.65
TAU	phosphorylates	gene	0.65
TAU	expressed_in	gene	0.65
TUMOR	treats	disease	0.65
TUMOR	causes	disease	0.65
TUMOR	interacts_with	disease	0.65
T CELLS	accumulates_in	cell_type	0.65
T CELLS	mediates	cell_type	0.65
T CELLS	transports	cell_type	0.65
TUMOR	protects_against	disease	0.65
TNF	mediates	gene	0.65
UBIQUITIN	inhibits	gene	0.65
TUMOR	associated_with	disease	0.65
T CELLS	associated_with	cell_type	0.65
T CELLS	targets	cell_type	0.60
TBI	protects_against	disease	0.60
TUMOR	activates	disease	0.60
T CELLS	protects_against	cell_type	0.60
T CELLS	treats	cell_type	0.60
TUMOR	inhibits	disease	0.60
T CELLS	stabilizes	cell_type	0.60
TUMOR	transports	disease	0.60
T CELLS	expressed_in	cell_type	0.60
T CELLS	inhibits	cell_type	0.60
T CELLS	causes	cell_type	0.60
TUMOR	targets	disease	0.60
T CELLS	regulates	cell_type	0.60
T CELLS	interacts_with	cell_type	0.60
T CELLS	activates	cell_type	0.60
TNF	causes	gene	0.60
TUMOR	regulates	disease	0.60
TNF	activates	gene	0.60
Spinal Cord	activates	cell_type	0.50
CELL PROLIFERATION	causes	concept	0.50
IL-1	activates	concept	0.50
DEMYELINATION	interacts_with	concept	0.50
NUCLEUS	activates	concept	0.50
CELL MIGRATION	protects_against	concept	0.50
CENTRAL NERVOUS SYSTEM	protects_against	concept	0.50
Thalamus	expressed_in	brain_region	0.50
Hypothalamus	expressed_in	brain_region	0.50
Substantia Nigra	expressed_in	brain_region	0.50
Prefrontal Cortex	expressed_in	brain_region	0.50
Temporal Lobe	expressed_in	brain_region	0.50

Incoming (2265)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	0.90
TET2	regulates	entity	0.90
anti-PD-1 therapy	targets	drug	0.90
NEURODEGENERATION	associated_with	disease	0.82
Senescence-Associated Secretory Phenotype	expressed_in	phenotype	0.80
SLC16A1	expressed_in	entity	0.80
Autophagy	associated_with	process	0.80
MICROGLIA	associated_with	cell_type	0.74
ALZHEIMER'S DISEASE	associated_with	disease	0.74
TNF	activates	gene	0.66
NOTCH	causes	gene	0.65
MYC	inhibits	gene	0.65
MTOR	inhibits	gene	0.65
ASTROCYTE	interacts_with	cell_type	0.65
MTOR	reduces	gene	0.65
FOXP3	regulates	gene	0.65
OCLN	inhibits	gene	0.65
CANCER	treats	disease	0.65
ISCHEMIA	inhibits	disease	0.65
NEURODEGENERATION	treats	disease	0.65
GLIOMA	expressed_in	disease	0.65
P53	activates	gene	0.65
IL-6	transports	gene	0.65
NEUTROPHIL	increases	cell_type	0.65
STING	targets	gene	0.65
ASTROCYTES	interacts_with	cell_type	0.65
AKT	regulates	gene	0.65
P62	degrades	gene	0.65
AKT	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	causes	gene	0.65
CANCER	targets	disease	0.65
NK CELL	activates	cell_type	0.65
NEURON	activates	cell_type	0.65
MICROGLIA	accumulates_in	cell_type	0.65
ALZHEIMER	causes	disease	0.65
ENDOTHELIAL	contributes_to	cell_type	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
ALZHEIMER'S	causes	disease	0.65
MICROGLIA	transports	cell_type	0.65
STING	inhibits	gene	0.65
CSF1R	inhibits	gene	0.65
NEURON	promotes	cell_type	0.65
NEURODEGENERATION	accumulates_in	disease	0.65
SPINAL CORD	activates	brain_region	0.65
MTOR	regulates	gene	0.65
MACROPHAGE	promotes	cell_type	0.65
NEURONS	interacts_with	cell_type	0.65
QUERCETIN	treats	drug	0.65
MONOCYTE	interacts_with	cell_type	0.65

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescent Cell ASM-Complement Cascade Intervention	0.852	neurodegeneration	Lipid raft composition changes in synapt
Senescent Cell Mitochondrial DNA Release	0.742	neurodegeneration	Senolytic therapy for age-related neurod
Soluble GAG-Mimetic Peptides Compete with HSPG for Tau Seed	0.510	neurodegeneration	Investigate prion-like spreading of tau
TH-neuron-restricted RGS6 rescue to test cell-autonomous the	0.460	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
Paraneoplastic myelopathies involve CD8+ T cell recognition	0.450	neuroinflammation	What are the specific pathophysiological

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia	clinical	dementia with behavioral and p	0.950	0.00	human patients	proposed	N/A
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NLRP3 Inflammasome Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Past, present and future perspectives on the science of aging. [PMID:41566049]	Fabrisia Ambrosio; Maxim N Artyomov; Ste	Nature aging	2026	0
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604]	["Orlikova-Boyer B", "Lorant A", "Gajula	Biomarker research	2024	0
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919]	["Li X", "Liu Y", "Ke J", "Wang Z", "Han	Advanced materials (Deerfield	2024	0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400]	Zhang Y, Zou M, Wu H, Zhu J, Jin T	Neurobiology of disease	2024	0
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044]	["Li Y", "Cui J", "Liu L", "Hambright W"	Cell death & disease	2024	0
Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958]	["Byrns C", "Perlegos A", "Miller K", "J	Nature	2024	0
Apoptotic stress causes mtDNA release during senescence and drives the SASP. [PMID:37821702]	["Victorelli S", "Salmonowicz H", "Chapm	Nature	2023	0
Exposome and unhealthy aging: environmental drivers from air pollution to occupa [PMID:37688657]	Pandics T, Major D, Fazekas-Pongor V, Sz	GeroScience	2023	0
cGAS-STING drives ageing-related inflammation and neurodegeneration. [PMID:37532932]	Gulen MF, Samson N, Keller A, Schwabenla	Nature	2023	0
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STI [PMID:36964253]	["Kim J", "Kim H", "Chung J"]	Experimental & molecular medic	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning T CELL in their description or question text

No additional research found