concept

ISG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

1Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	ISG
Key Genes/Proteins	Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, AND
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Amyloid, Apoptosis, Autophagy
Linked Hypotheses	1 hypotheses

Wiki Pages (2)

Knowledge base pages for this entity

ISG15 — Interferon-Stimulated Gene 15

gene · 1513 words

→

ISG15 Protein — Interferon-Stimulated Gene 15

protein · 603 words

→

Pathway Diagram

graph TD
    ISG["ISG"]
    ISG -->|"activates"| Als["Als"]
    ISG -->|"activates"| Complement["Complement"]
    ISG -->|"activates"| Ms["Ms"]
    ISG -->|"activates"| Ischemia["Ischemia"]
    ISG -->|"activates"| Infection["Infection"]
    ISG -->|"activates"| Viral_Infection["Viral Infection"]
    ISG -->|"activates"| Neuroinflammation["Neuroinflammation"]
    ISG -->|"activates"| Inflammation["Inflammation"]
    TYPE_I_IFN["TYPE_I_IFN"] -->|"activates"| ISG
    VIRAL_INFECTIONS["VIRAL INFECTIONS"] -->|"activates"| ISG
    TLR3["TLR3"] -->|"activates"| ISG
    CYTOKINES["CYTOKINES"] -->|"activates"| ISG
    FAS["FAS"] -->|"activates"| ISG
    MICROGLIA["MICROGLIA"] -->|"activates"| ISG
    UBIQUITIN["UBIQUITIN"] -->|"activates"| ISG
    COMPLEMENT["COMPLEMENT"] -->|"activates"| ISG

Outgoing (68)

Target	Relation	Type	Str
Als	activates	disease	0.75
Complement	activates	pathway	0.70
microglia	expressed_in	cell_type	0.70
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Infection	activates	disease	0.65
ALS	activates	disease	0.65
Viral Infection	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Stroke	activates	disease	0.65
Macrophage	activates	cell_type	0.60
Microglia	inhibits	cell_type	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
STING	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARP12	activates	gene	0.60
LRRK2	expressed_in	gene	0.60
Oxidative Stress	activates	pathway	0.60
PARKINSON	activates	gene	0.60
Autophagy	activates	pathway	0.60
CXCL10	expressed_in	gene	0.60
Microglia	expressed_in	cell_type	0.60
Apoptosis	activates	pathway	0.60
TNFR1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Ras	activates	protein	0.60
NRF2	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
DNA	activates	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
Necroptosis	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Interferon	activates	protein	0.60
Cytokine	activates	protein	0.60
Actin	activates	protein	0.60
Caspase	activates	protein	0.60
HERC5	degrades	gene	0.60
Ubiquitin	activates	protein	0.60
IFN	activates	gene	0.60

Incoming (33)

Source	Relation	Type	Str
IFNG	upregulates	gene	0.95
TYPE_I_IFN	activates	protein	0.64
MICROGLIA	expressed_in	gene	0.60
FAS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
RIPK3	activates	gene	0.60
TNF	activates	gene	0.60
TNFR1	activates	gene	0.60
SYNAPSE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
LRRK2	expressed_in	gene	0.60
CGAS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
HERC6	degrades	gene	0.60
TLR3	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	activates	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
IFN	activates	gene	0.60
RIPK1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
NRF2	activates	gene	0.60
STROKE	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNA	activates	gene	0.60
IFN	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
PARKINSON	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ISG Threshold Model Explains Acute vs Chronic Neurodegenerat	0.480	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ISG in their description or question text

No additional research found