gene 724 words KG: HMOX1
Contents

HMOX1 — Heme Oxygenase 1

🧬 Gene Info
Gene SymbolHMOX1
Full NameHeme Oxygenase 1
Chromosome22q12
Protein TypeEnzyme
FunctionHMOX1 degrades heme to produce biliverdin (which is further converted to bilirubin), iron (which induces ferritin), and carbon monoxide (a signaling molecule).
PathwaysAutophagy, Chaperone, Immune Response, Mitophagy, Oxidative Stress
UniProt IDP09601
NCBI Gene ID3162
Ensembl IDENSG00000101129
OMIM141250
GeneCardsHMOX1
Human Protein AtlasHMOX1
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Diabetes
Known Drugs/CompoundsL. reuteri-CMVs, rapamycin
InteractionsACHE, AKK, ALOX12, ALOX15, ALOX5, ALOXE3
KG Connections502 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: regulates
ADRB2 Gene
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

NFE2L2 activates HMOX1
HMOX1 inhibits ferroptosis
NRF2 regulates HMOX1
ALOX5 activates HMOX1
HMOX1 activates ALOX15
HMOX1 activates ALOX12
HMOX1 activates NFE2L2
HMOX1 activates FER
OCLN activates HMOX1
HMOX1 activates CD4

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