gene

TRPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

256Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TRPA1 encodes a non-selective cation channel activated by oxidative stress, irritants, and inflammatory mediators. Implicated in neuropathic pain, neuroinflammation, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	TRPA1
Protein Type	Protein
Function	is a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Molecular Weight	108 kDa
Amino Acids	959 aa
Pathways	Epigenetic, Nf-Κb, Toll-Like Receptor
UniProt ID	Search UniProt
GeneCards	TRPA1
Human Protein Atlas	TRPA1
Associated Diseases	Alzheimer, Cancer, stroke
Interactions	AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections	256 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TRPA1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPA1["TRPA1 Channel"] -->|"Senses"| Oxidative["Oxidative Stress"]
    TRPA1 -->|"Activated by"| Irritants["Irritants and Inflammatory Mediators"]
    TRPA1 -->|"Permits"| CaInflux["Ca2+ Influx"]
    CaInflux -->|"Activates"| NF_kB["NF-kappaB Pathway"]
    NF_kB -->|"Induces"| CCL3["CCL3 Chemokine"]
    NF_kB -->|"Induces"| CXCL2["CXCL2 Chemokine"]
    TRPA1 -->|"Regulates"| CHRNA7["CHRNA7 Receptor"]
    TRPA1 -->|"Modulates"| FOXP3["FOXP3 / T-reg Response"]
    CaInflux -->|"Triggers"| Neuroinflammation["Neuroinflammation"]
    Neuroinflammation -.Contributes to.-> AD["Alzheimer's Disease"]
    TRPA1 -.Implicated in.-> Pain["Neuropathic Pain"]

Outgoing (154)

Target	Relation	Type	Str
inflammatory pain	contributes_to	unknown	0.90
MECHANOTRANSDUCTION	involved_in	entity	0.90
Periodontal Ligament Cells	expressed_in	cell_type	0.85
Periodontal Ligament Cell	expressed_in	cell_type	0.85
Blood Flow	modulates	phenotype	0.85
orthodontic tooth movement	involved_in	process	0.85
Calcium Dynamics	regulates	process	0.80
Brain Capillary Endothelial Cells	expressed_in	cell_type	0.80
Neurovascular Coupling	contributes_to	process	0.80
Inflammation	activates	disease	0.75
INFLAMMATION	activates	gene	0.70
Alzheimer	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Migraine	inhibits	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Hypertension	regulates	disease	0.65
Ms	inhibits	disease	0.65
Stroke	regulates	disease	0.65
Tumor	activates	disease	0.65
Psoriasis	activates	disease	0.65
Stroke	contributes_to	disease	0.65
Hypertension	contributes_to	disease	0.65
Neuron	regulates	cell_type	0.60
endothelial cells	expressed_in	cell_type	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
TRPM8	expressed_in	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60

Incoming (102)

Source	Relation	Type	Str
GPR32	mediates	protein	0.95
Resolvin D1	inhibits	unknown	0.95
Resolvin D2	inhibits	unknown	0.95
TNF-α	upregulates	protein	0.95
Frostbite Injury	upregulates	disease	0.90
TNF	modulates	entity	0.90
TNF-Α	upregulates	protein	0.85
TNF	upregulates	entity	0.85
TNF-Α	modulates	protein	0.80
TNFA	activates	protein	0.64
TRPV1	causes	gene	0.60
IL10	activates	gene	0.60
IL1B	activates	gene	0.60
NOD2	activates	gene	0.60
TNF	activates	gene	0.60
TRPV1	activates	gene	0.60
SCN5A	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCNN1A	causes	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
RAS	activates	gene	0.60
NF-ΚB	regulates	gene	0.60
ANG	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
KCNN4	associated_with	entity	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPM7	causes	gene	0.60
TRPM8	expressed_in	gene	0.60
APP	inhibits	gene	0.60
KCNMA1	associated_with	entity	0.60
RNA	associated_with	gene	0.60
PIEZO	expressed_in	gene	0.60
PKD2	expressed_in	gene	0.60
STROKE	regulates	gene	0.60
AND	inhibits	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ASTROCYTE	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
WNT	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
PIEZO1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPA1 in their description or question text

No additional research found