gene

P2RX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

14Outgoing

16Incoming

0Experiments

0Debates

Summary

P2RX3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX3
Chromosome	11q12.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	sensory neurons and play crucial roles in pain sensation, taste transduction, and autonomic functions[@burnstock2018]
Amino Acids	290 aa
UniProt ID	P56378
NCBI Gene ID	5024
OMIM	602243
GeneCards	P2RX3
Human Protein Atlas	P2RX3
Official Symbol	P2RX3
Official Full Name	Purinergic Receptor P2X Ligand-Gated Ion Channel 3
Protein	P2X3 Receptor
Orphan sites	Residues on adjacent subunits
Associated Diseases	neurodegeneration
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: P2RX3 — AlphaFold P56378 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P2RX3 Gene

gene · 927 words

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Pathway Diagram

graph TD
    P2RX3["P2RX3"]
    Inflammation{"Inflammation"}
    P2RX3 -->|"activates"| Inflammation
    Aging{"Aging"}
    P2RX3 -->|"activates"| Aging
    Ms{"Ms"}
    P2RX3 -->|"activates"| Ms
    RELA["RELA"]
    P2RX3 -->|"regulates"| RELA
    SYP["SYP"]
    P2RX3 -->|"regulates"| SYP
    CHRNA7["CHRNA7"]
    P2RX3 -->|"regulates"| CHRNA7
    SYT1["SYT1"]
    P2RX3 -->|"regulates"| SYT1
    STAT3["STAT3"]
    P2RX3 -->|"regulates"| STAT3
    HMOX1["HMOX1"]
    P2RX3 -->|"regulates"| HMOX1
    TRPV1["TRPV1"]
    P2RX3 -->|"regulates"| TRPV1
    P2RY2["P2RY2"]
    P2RX3 -->|"regulates"| P2RY2
    FOXP3["FOXP3"]
    P2RX3 -->|"regulates"| FOXP3
    PANX1["PANX1"]
    PANX1 -->|"regulates"| P2RX3
    S100B["S100B"]
    S100B -->|"regulates"| P2RX3
    RELB["RELB"]
    RELB -->|"regulates"| P2RX3
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| P2RX3
    CASP3["CASP3"]
    CASP3 -->|"regulates"| P2RX3
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| P2RX3
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| P2RX3
    GENES["GENES"]
    GENES -->|"regulates"| P2RX3
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| P2RX3
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| P2RX3
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| P2RX3
    SYT2["SYT2"]
    SYT2 -->|"regulates"| P2RX3
    style P2RX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
RELA	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
P2RY2	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
GENES	regulates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P2RX3 in their description or question text

No additional research found