enzyme

ALOX15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALOX15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

2Experiments

2Debates

Summary

ALOX15 is an entity related to neurodegeneration research. Key relationships include: inhibits, activates, regulates. Associated with ALS, Aging, Als. Connected to 185 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ALOX15
Full Name	ALOX15 - Arachidonate 15-Lipoxygenase
Aliases	Arachidonate 15-Lipoxygenase
Chromosome	17p13.2
Protein Type	Gene
Target Class	Enzyme
Function	The enzyme contains a non-heme iron center essential for its catalytic activity and requires iron for proper folding and function.
Mechanism of Action	Small molecule inhibitors targeting the active site iron and substrate binding
Primary Expression	various tissues including: [@zhang2020] - Brain: Astrocytes, microglia, and cer
Druggability	Low (0.38)
Clinical Stage	Approved
Molecular Weight	~75 kDa
Pathways	Allosteric Binding, Allosteric Binding Sites, Enzyme Dimers, Enzyme Monomer Subunits, Nf-Kb
UniProt ID	P16050
GeneCards	ALOX15
Human Protein Atlas	ALOX15
Associated Diseases	Als, Cancer, Cardiovascular, Cardiovascular Diseases, Fibrosis
Known Drugs/Compounds	omega-3 fatty acids, omega-6 fatty acids
Interactions	ACSL4, ALOX, ALOX12, ALOX15B, Alox15 Dimer, Alox15 Dimers
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	ALOX15-Driven Enzymatic Ferroptosis in AD Oligoden Astrocytic Lipoxin A4 Pathway Restoration via ALOX
KG Connections	352 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ALOX15 — AlphaFold P16050 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ALOX15 - Arachidonate 15-Lipoxygenase

gene · 840 words

→

ALOX15 Protein

protein · 746 words

→

Pathway Diagram

graph TD
    ALOX15["ALOX15"] -->|"substrate of"| Polyenoic_Fatty_Acids["Polyenoic Fatty Acids"]
    ALOX15["ALOX15"] -->|"associated"| Hydroperoxy_Derivatives["Hydroperoxy Derivatives"]
    ALOX15["ALOX15"] -->|"involved in"| Arachidonic_Acid_Oxygenation["Arachidonic Acid Oxygenation"]
    ALOX15["ALOX15"] -->|"modulates"| Allosteric_Binding_Sites["Allosteric Binding Sites"]
    ALOX15["ALOX15"] -->|"interacts"| ALOX15B["ALOX15B"]
    ALOX15["ALOX15"] -->|"associated"| Als["Als"]
    h_ac55ff26["h-ac55ff26"] -->|"targets"| ALOX15["ALOX15"]
    DHODH["DHODH"] -.->|"inhibits"| ALOX15["ALOX15"]
    LOX["LOX"] -->|"associated"| ALOX15["ALOX15"]
    ALOX5["ALOX5"] -->|"contributes to"| ALOX15["ALOX15"]
    style ALOX15 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (256)

Target	Relation	Type	Str
Allosteric Enzyme	associated_with	mechanism	0.95
Cardiomyocyte Ferroptosis	associated_with	process	0.95
polyunsaturated fatty acids	associated_with	compound	0.95
dioxygenase activity	mediates	process	0.95
non-heme iron	binds	compound	0.90
oxidative stress	mediates	process	0.90
inflammation	promotes	process	0.90
15-HpETE	associated_with	compound	0.90
Biological Function Specialization	mediates	phenotype	0.90
cardiomyocyte ferroptosis	promotes	process	0.90
Lipoxygenases	associated_with	enzyme	0.90
Myocardial Ischemia-Reperfusion Injury	contributes_to	disease	0.90
neuroprotectin D1	associated_with	compound	0.90
Lipid-Ros	associated_with	compound	0.90
Cardiomyocyte	expressed_in	cell_type	0.90
Ferroptosis	involved_in	process	0.90
Eicosanoid Metabolism	involved_in	pathway	0.88
mammalian cells	expressed_in	cell_type	0.85
Allosteric Binding Sites	associated_with	mechanism	0.85
Cardiac Function	regulates	phenotype	0.85
Metabolic Disorders	implicated_in	disease	0.85
Neurological Disorders	implicated_in	disease	0.85
Kidney Diseases	implicated_in	disease	0.85
Cardiovascular Diseases	implicated_in	disease	0.85
cytokine production	upregulates	process	0.85
lipid-ROS production	promotes	process	0.85
Therapeutic Target	therapeutic_target	phenotype	0.82
ALOXE3	associated_with	gene	0.80
15-HPETE	produces	compound	0.80
LIPIDS	catalyzes	compound	0.80
lipoxygenase	associated_with	enzyme	0.80
neuroprotection	protects_against	process	0.80
ferroptosis	participates_in	pathway	0.80
Alox15 Dimer	interacts_with	protein	0.80
Alox15 Dimers	interacts_with	protein	0.80
resolution of inflammation	modulates	process	0.80
FERROPTOSIS	promotes	process	0.80
15-lipoxygenase	encodes	protein	0.80
ALOX15B	associated_with	gene	0.75
Gastric Cancer	biomarker_for	disease	0.75
Allosteric Binding Sites	interacts_with	mechanism	0.75
lipid peroxidation	enhances	mechanism	0.70
ferroptosis	activates	mechanism	0.70
Autophagy	activates	pathway	0.70
Ferroptosis	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
ALOX15B	interacts_with	gene	0.70
ALOX12	associated_with	gene	0.70
ALOX12	activates	gene	0.70

Incoming (99)

Source	Relation	Type	Str
h-var-97b18b880d	targets_gene	hypothesis	0.90
omega-3 fatty acids	interacts_with	compound	0.90
MIR125B	targets	biomarker	0.90
omega-6 fatty acids	interacts_with	compound	0.90
h-ac55ff26	targets	hypothesis	0.90
ALOX5	associated_with	gene	0.85
ALOXE3	associated_with	gene	0.85
Mir-522	inhibits	biomarker	0.85
Liproxstatin-1	downregulates	drug	0.85
MIR125B	inhibits	gene	0.85
Mir125B	targets	biomarker	0.80
FERROPTOSIS	activates	gene	0.70
ALOX12	associated_with	gene	0.60
CPT1A	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
ALOX12	activates	gene	0.60
FER	activates	gene	0.60
NFE2L2	activates	gene	0.60
P53	activates	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ALOX	interacts_with	gene	0.60
GENES	inhibits	gene	0.60
MIRNAS	inhibits	gene	0.60
MICRORNAS	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
APOPTOSIS	causes	gene	0.60
ROS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CHAC1	activates	gene	0.60
SLC7A11	activates	gene	0.60
NOX4	activates	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
ALOXE3	activates	gene	0.60
GSH	activates	gene	0.60
ACSL4	biomarker_for	gene	0.60
ALZHEIMER	regulates	gene	0.60
AGING	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th	0.695	neurodegeneration	Neuroinflammation resolution mechanisms
ALOX15 Inhibition Combined with Selenium Augmentation for Sy	0.580	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (2)

Scientific analyses that reference this entity

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924]	Cai W, Liu L, Shi X, Liu Y, Wang J, Fang	Circulation	2023	1
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829]	Tong J, Lan XT, Zhang Z, Liu Y, Sun DY,	Acta Pharmacol Sin	2023	1
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859]	Zhang H, Deng T, Liu R, Ning T, Yang H,	Mol Cancer	2020	1
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102]	Zhao Y, Bhattacharjee S, Jones BM, Hill	Mol Neurobiol	2014	1
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595]	Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z	Functional & integrative genom	2026	0
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658]	Hou G, Luan J, Xu X, Qin J, Ma S et al.	Adv Sci (Weinh)	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126]	Li X, Xu Z, Ju P, Dong M, Wang Y et al.	Phytomedicine	2026	0
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540]	Man GCW, Borchert A, Zhang T, Hung SW, K	Antioxidants (Basel, Switzerla	2026	0
ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922]	Hilman A, Ishii Y, Wijatniko BD, Rini DM	FASEB journal : official publi	2026	0
Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293]	Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu	FASEB journal : official publi	2026	0
FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238]	Chenxi Shen; Yuan Cao; Jinling Wei; Xiny	Respiratory research	2026	0
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747]	Deng S, Cao H, Li T, Wang X, Meng J, Zen	Gut microbes	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839]	Yang X, Chen H, Shen W, Chen Y, Lin Z, Z	Nature communications	2024	0
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520]	Shen L, Huang H, Li J, Chen W, Yao Y, Hu	Frontiers in immunology	2023	0
A survey of human brain transcriptome diversity at the single cell level. [PMID:26060301]	["Darmanis S", "Sloan S", "Zhang Y", "En	Proceedings of the National Ac	2015	0
Exploring sRNA-mediated gene silencing mechanisms using artificial small RNAs de [PMID:23393193]	["Park H", "Bak G", "Kim S", "Lee Y"]	Nucleic acids research	2013	0

Debates (2)

Multi-agent debates referencing this entity

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

closed · Rounds: 5 · Score: 0.59 · 2026-04-16

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Related Research

Hypotheses and analyses mentioning ALOX15 in their description or question text

No additional research found