gene

SYP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

456Connections
1Hypotheses
2Analyses
50Outgoing
50Incoming
0Experiments
2Debates

Summary

SYP is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with Aging, Als, Epilepsy. Connected to 68 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight38 kDa
Amino Acids313 aa
Exons4
PathwaysOxidative Stress
UniProt ID[P08247](https://www.uniprot.org/uniprot/P08247)
Ensembl IDENSG00000157193
OMIM313475
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesAlzheimer, Motor function, Motor function recovery, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACHE, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX HypothesesAge-driven synaptic gene silencing precedes neuron
KG Connections448 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SYP Gene

gene · 785 words

Synaptophysin Protein (SYP)

protein · 882 words

Pathway Diagram

graph TD
    SYP["SYP"]
    Inflammation{"Inflammation"}
    SYP -->|"activates"| Inflammation
    Aging{"Aging"}
    SYP -->|"activates"| Aging
    Ms{"Ms"}
    SYP -->|"activates"| Ms
    SYNCRIP["SYNCRIP"]
    SYP -->|"interacts with"| SYNCRIP
    Neurogenesis(["Neurogenesis"])
    SYP -->|"interacts with"| Neurogenesis
    CHRNA7["CHRNA7"]
    SYP -->|"regulates"| CHRNA7
    SYT1["SYT1"]
    SYP -->|"regulates"| SYT1
    STAT3["STAT3"]
    SYP -->|"regulates"| STAT3
    HMOX1["HMOX1"]
    SYP -->|"regulates"| HMOX1
    TRPV1["TRPV1"]
    SYP -->|"regulates"| TRPV1
    P2RY2["P2RY2"]
    SYP -->|"regulates"| P2RY2
    FOXP3["FOXP3"]
    SYP -->|"regulates"| FOXP3
    SYNCRIP -->|"interacts with"| SYP
    PANX1["PANX1"]
    PANX1 -->|"regulates"| SYP
    S100B["S100B"]
    S100B -->|"regulates"| SYP
    RELB["RELB"]
    RELB -->|"regulates"| SYP
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| SYP
    CASP3["CASP3"]
    CASP3 -->|"regulates"| SYP
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| SYP
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| SYP
    GENES["GENES"]
    GENES -->|"regulates"| SYP
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| SYP
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| SYP
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| SYP
    style SYP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (235)

TargetRelationTypeStr
mRNAbindscompound0.95
Temporal Patterning of Neural Progenitorsinvolved_inprocess0.90
Synaptic plasticitycomponent_ofprocess0.90
Postembryonic Neurogenesisassociated_withprocess0.90
Striatumexpressed_instructure0.90

Incoming (221)

SourceRelationTypeStr
SV2Acorrelates_withprotein0.95
NCSEdownregulatesdisease0.90
SV2Aco_expressed_withprotein0.90
Oxytocinupregulatesdrug0.90
AdipoRonupregulatesdrug0.88

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Age-driven synaptic gene silencing precedes neuronal loss in 0.390 Alzheimer's disease Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning SYP in their description or question text

No additional research found