Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYP is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with Aging, Als, Epilepsy. Connected to 68 entities in the SciDEX knowledge graph.
No AI portrait yet
| Gene Symbol | SYP |
| Full Name | Synaptophysin |
| Chromosome | Xp11.23 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 38 kDa |
| Amino Acids | 313 aa |
| Exons | 4 |
| Pathways | Oxidative Stress |
| UniProt ID | [P08247](https://www.uniprot.org/uniprot/P08247) |
| Ensembl ID | ENSG00000157193 |
| OMIM | 313475 |
| GeneCards | SYP |
| Human Protein Atlas | SYP |
| Associated Diseases | Alzheimer, Motor function, Motor function recovery, neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACHE, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID |
| SciDEX Hypotheses | Age-driven synaptic gene silencing precedes neuron |
| KG Connections | 448 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SYP["SYP"]
Inflammation{"Inflammation"}
SYP -->|"activates"| Inflammation
Aging{"Aging"}
SYP -->|"activates"| Aging
Ms{"Ms"}
SYP -->|"activates"| Ms
SYNCRIP["SYNCRIP"]
SYP -->|"interacts with"| SYNCRIP
Neurogenesis(["Neurogenesis"])
SYP -->|"interacts with"| Neurogenesis
CHRNA7["CHRNA7"]
SYP -->|"regulates"| CHRNA7
SYT1["SYT1"]
SYP -->|"regulates"| SYT1
STAT3["STAT3"]
SYP -->|"regulates"| STAT3
HMOX1["HMOX1"]
SYP -->|"regulates"| HMOX1
TRPV1["TRPV1"]
SYP -->|"regulates"| TRPV1
P2RY2["P2RY2"]
SYP -->|"regulates"| P2RY2
FOXP3["FOXP3"]
SYP -->|"regulates"| FOXP3
SYNCRIP -->|"interacts with"| SYP
PANX1["PANX1"]
PANX1 -->|"regulates"| SYP
S100B["S100B"]
S100B -->|"regulates"| SYP
RELB["RELB"]
RELB -->|"regulates"| SYP
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| SYP
CASP3["CASP3"]
CASP3 -->|"regulates"| SYP
SOCS3["SOCS3"]
SOCS3 -->|"regulates"| SYP
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| SYP
GENES["GENES"]
GENES -->|"regulates"| SYP
CXCL2["CXCL2"]
CXCL2 -->|"regulates"| SYP
SNAP25["SNAP25"]
SNAP25 -->|"regulates"| SYP
P2RX7["P2RX7"]
P2RX7 -->|"regulates"| SYP
style SYP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| mRNA | binds | compound | 0.95 |
| Temporal Patterning of Neural Progenitors | involved_in | process | 0.90 |
| Synaptic plasticity | component_of | process | 0.90 |
| Postembryonic Neurogenesis | associated_with | process | 0.90 |
| Striatum | expressed_in | structure | 0.90 |
| Spinal cord | expressed_in | structure | 0.90 |
| Neural Progenitor Temporal Patterning | involved_in | process | 0.90 |
| Post-transcriptional Regulation | mediates | process | 0.90 |
| Motor function | associated_with | phenotype | 0.88 |
| Reinnervation | biomarker_for | process | 0.88 |
| CDNF | co_expressed_with | protein | 0.85 |
| Motor function recovery | associated_with | phenotype | 0.85 |
| Synaptic Dysfunction | biomarker_for | mechanism | 0.85 |
| Neural Fate Specification | regulates | process | 0.85 |
| Neuropathic pain | protects_against | disease | 0.82 |
| Hippocampal injury | biomarker_for | process | 0.80 |
| Neuronal Damage | protects_against | process | 0.80 |
| Neural Fate Specification | involved_in | process | 0.80 |
| Inflammation | activates | disease | 0.75 |
| oxidative stress response | participates_in | pathway | 0.70 |
| hippocampus | expressed_in | brain_region | 0.70 |
| Alzheimer | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| NEURON | causes | cell_type | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Pyroptosis | therapeutic_target | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Necroptosis | therapeutic_target | disease | 0.65 |
| tau | co_discussed | concept | 0.65 |
| autophagy | co_discussed | concept | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| mitochondria | co_discussed | concept | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SV2A | correlates_with | protein | 0.95 |
| NCSE | downregulates | disease | 0.90 |
| SV2A | co_expressed_with | protein | 0.90 |
| Oxytocin | upregulates | drug | 0.90 |
| AdipoRon | upregulates | drug | 0.88 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.88 |
| Chlorogenic acid | upregulates | compound | 0.85 |
| Surgery | downregulates | process | 0.85 |
| Nerve implantation | upregulates | entity | 0.85 |
| Fisetin | upregulates | compound | 0.85 |
| Copper | inhibits | compound | 0.85 |
| Imp | interacts_with | protein | 0.85 |
| Transcranial near-infrared light | upregulates | compound | 0.80 |
| BDNF | upregulates | gene | 0.80 |
| Copper | downregulates | compound | 0.80 |
| MECP2 | co_expressed_with | protein | 0.75 |
| REST | co_expressed_with | protein | 0.75 |
| MAPT | co_discussed | gene | 0.65 |
| SQSTM1 | co_discussed | gene | 0.65 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| SYNAPSE | activates | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| ANXIETY | activates | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| EZH2 | therapeutic_target | gene | 0.60 |
| SLC17A7 | co_discussed | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| GAP43 | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| NEURODEGENERATION | expressed_in | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| HO-1 | activates | gene | 0.60 |
| BCL-2 | expressed_in | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| SYNCRIP | regulates | entity | 0.60 |
| HSP70 | inhibits | gene | 0.60 |
| SLC17A7 | biomarker_for | gene | 0.60 |
| SLC17A6 | biomarker_for | gene | 0.60 |
| SLC12A5 | biomarker_for | gene | 0.60 |
| SYN2 | biomarker_for | gene | 0.60 |
| GAD1 | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Age-driven synaptic gene silencing precedes neuronal loss in | 0.390 | Alzheimer's disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning SYP in their description or question text
No additional research found