gene

FGF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

479Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

FGF2 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, regulates, activates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 263 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FGF2
Full Name	Fibroblast Growth Factor 2
Chromosome	4q28
Function	FGF2 (basic FGF) encodes a member of the fibroblast growth factor family that binds to FGFR1-4 with varying affinities.
Pathways	Akt, Mapk, Pi3K, Pi3K/Akt
UniProt ID	[P09038](https://www.uniprot.org/uniprot/P09038)
Ensembl ID	ENSG00000108639
OMIM	134760
GeneCards	FGF2
Human Protein Atlas	FGF2
Associated Diseases	Aging, ALS, ANGIOGENESIS, Cancer, Carcinoma, CELL PROLIFERATION
Interactions	AND, ANGPT1, App, APP, AUTOPHAGY, Aβ
KG Connections	479 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    FGF2["FGF2
Fibroblast Growth Factor 2"]
    EGR1["EGR1
Early Growth Response 1"]
    ANGPT1["ANGPT1
Angiopoietin 1"]
    PDGFRB["PDGFRB
Platelet Derived Growth
Factor Receptor Beta"]
    VEGFB["VEGFB
Vascular Endothelial
Growth Factor B"]
    TLR4["TLR4
Toll-like Receptor 4"]
    HSPA1A["HSPA1A
Heat Shock Protein
Family A Member 1A"]
    
    Angiogenesis["Angiogenesis
Pathway"]
    Fibroblast_Activation["Fibroblast
Activation"]
    
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    Alzheimer["Alzheimer's
Disease"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    MS["Multiple
Sclerosis"]
    
    EGR1 -->|"regulates"| FGF2
    FGF2 -->|"activates"| EGR1
    FGF2 -->|"activates"| ANGPT1
    FGF2 -->|"activates"| PDGFRB
    FGF2 -->|"activates"| VEGFB
    FGF2 -->|"regulates"| TLR4
    FGF2 -->|"regulates"| HSPA1A
    
    FGF2 -->|"promotes"| Angiogenesis
    FGF2 -->|"causes"| Fibroblast_Activation
    
    FGF2 -->|"biomarker_for"| ALS
    FGF2 -->|"biomarker_for"| Alzheimer
    FGF2 -->|"biomarker_for"| Neurodegeneration
    FGF2 -->|"biomarker_for"| Neuroinflammation
    FGF2 -->|"inhibits"| MS
    
    ANGPT1 --> Angiogenesis
    VEGFB --> Angiogenesis
    TLR4 --> Neuroinflammation
    
    style FGF2 fill:#006494
    style EGR1 fill:#4a1a6b
    style ANGPT1 fill:#4a1a6b
    style PDGFRB fill:#4a1a6b
    style VEGFB fill:#4a1a6b
    style TLR4 fill:#4a1a6b
    style HSPA1A fill:#1b5e20
    style Angiogenesis fill:#1b5e20
    style MS fill:#1b5e20
    style ALS fill:#ef5350
    style Alzheimer fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Fibroblast_Activation fill:#5d4400

Outgoing (311)

Target	Relation	Type	Str
angiogenesis	promotes	process	0.95
Angiogenesis	involved_in	process	0.95
Fibroblast Activation	associated_with	process	0.90
fibroblast activation	causes	phenotype	0.90
MAPK3	activates	protein	0.90
MAPK1	activates	protein	0.90
EGR1	activates	protein	0.90
Endothelial Cells	expressed_in	cell_type	0.85
DNA synthesis	promotes	process	0.85
Amyloid Pathology	upregulates	process	0.80
stem cell proliferation	promotes	process	0.80
Amyloid Pathology	biomarker_for	process	0.80
Als	inhibits	disease	0.75
stem cells	expressed_in	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
ALS	regulates	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Als	regulates	disease	0.65
Carcinoma	implicated_in	disease	0.65
Aging	implicated_in	disease	0.65
CYTOKINES	interacts_with	phenotype	0.65
AXONAL DEGENERATION	interacts_with	phenotype	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
Ms	regulates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Hypertension	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Alzheimer	protects_against	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Ms	inhibits	disease	0.65
ANGIOGENESIS	interacts_with	phenotype	0.65
Tumor	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Als	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (168)

Source	Relation	Type	Str
ITGAV	binds	gene	0.95
EGR1	upregulates	gene	0.95
ITGB3	binds	gene	0.95
INTEGRIN ΑVΒ3	interacts_with	receptor	0.90
EGR1	regulates	protein	0.90
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.88
PI3K	associated_with	gene	0.74
ALZHEIMER'S DISEASE	associated_with	disease	0.66
BDNF	associated_with	gene	0.66
AKT	associated_with	gene	0.66
APOE	associated_with	gene	0.66
MICROGLIA	activates	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
PDGFRB	activates	gene	0.60
PARKINSON	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
MIRNAS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
MAPK	activates	gene	0.60
S100A8	regulates	gene	0.60
EGR1	activates	gene	0.60
SQSTM1	biomarker_for	gene	0.60
STAT3	associated_with	gene	0.60
BDNF	biomarker_for	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AND	associated_with	gene	0.60
BMP2	activates	gene	0.60
VEGF	activates	gene	0.60
FGF1	interacts_with	gene	0.60
ERK1	activates	gene	0.60
P38	regulates	gene	0.60
VEGFB	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
RAS	expressed_in	gene	0.60
FGFR1	interacts_with	gene	0.60
HSPG2	inhibits	gene	0.60
IL4	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
CXCL10	associated_with	gene	0.60
HSPA1A	regulates	gene	0.60
VEGFA	biomarker_for	gene	0.60
CXCL10	regulates	gene	0.60
IL9	activates	gene	0.60
CHIT1	biomarker_for	gene	0.60
IRS1	associated_with	gene	0.60
ANGPT1	activates	gene	0.60
AKT	regulates	gene	0.60
APOE	biomarker_for	gene	0.60
NAMPT	regulates	gene	0.60
CSF2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

closed · Rounds: 3 · Score: 0.68 · 2026-04-02

Related Research

Hypotheses and analyses mentioning FGF2 in their description or question text

No additional research found

FGF2

Understanding Entity Pages

Summary

Wiki Pages (7)

FGF2 — Fibroblast Growth Factor 2

FGF23 — Fibroblast Growth Factor 23

FGF21 — Fibroblast Growth Factor 21

Fibroblast Growth Factor 21 (FGF21)

FGF22 — Fibroblast Growth Factor 22

FGF20 Gene

FGF20 Protein