gene

GATA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GATA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GATA2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 115 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GATA2
Full Name	GATA Binding Protein 2
Aliases	Page for GATA2
Protein Type	Transcription Factor
Function	GATA2 functions as a dual-function transcription factor with roles in development and adult tissue homeostasis:
Primary Expression	premigratory and migrating neural crest cells, where it regulates genes involved in melanocyte, Schwann cell, and peripheral neuron development
Pathways	Apoptosis, Cholesterol
Ensembl ID	ENSG00000179348
GeneCards	GATA2
Human Protein Atlas	GATA2
Associated Diseases	Als, Alzheimer, Infection, Inflammation, Lymphoma
Interactions	AKT, AND, ANG, AQP3, AQP4, CANCER
KG Connections	162 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GATA2 - GATA Binding Protein 2

gene · 1090 words

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Pathway Diagram

graph TD
    GATA2["GATA2"]
    Als{"Als"}
    GATA2 -->|"activates"| Als
    Ms{"Ms"}
    GATA2 -->|"regulates"| Ms
    Alzheimer{"Alzheimer"}
    GATA2 -->|"therapeutic target"| Alzheimer
    GATA2 -->|"therapeutic target"| Als
    GATA2 -->|"therapeutic target"| Ms
    ALS{"ALS"}
    GATA2 -->|"regulates"| ALS
    GATA2 -->|"regulates"| Alzheimer
    HIPPO["HIPPO"]
    GATA2 -->|"activates"| HIPPO
    NFATC1["NFATC1"]
    GATA2 -->|"regulates"| NFATC1
    MST1["MST1"]
    GATA2 -->|"activates"| MST1
    YAP["YAP"]
    GATA2 -->|"regulates"| YAP
    MST2["MST2"]
    GATA2 -->|"activates"| MST2
    AQP4["AQP4"]
    AQP4 -->|"activates"| GATA2
    GATA3["GATA3"]
    GATA3 -->|"activates"| GATA2
    TIMP1["TIMP1"]
    TIMP1 -->|"therapeutic target"| GATA2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| GATA2
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| GATA2
    PTK2B["PTK2B"]
    PTK2B -->|"therapeutic target"| GATA2
    EGR1["EGR1"]
    EGR1 -->|"protects against"| GATA2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| GATA2
    ATF3["ATF3"]
    ATF3 -->|"protects against"| GATA2
    ALZHEIMER_S_DISEASE -->|"regulates"| GATA2
    BANG["BANG"]
    BANG -->|"regulates"| GATA2
    GENES["GENES"]
    GENES -->|"regulates"| GATA2
    style GATA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (111)

Target	Relation	Type	Str
ALS	regulates	disease	0.75
ESR1	therapeutic_target	gene	0.70
Myeloma	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Lymphoma	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ESR1	regulates	gene	0.60
MTOR	activates	gene	0.60
PPARG	protects_against	gene	0.60
EP300	therapeutic_target	gene	0.60
TP53	regulates	gene	0.60
EGFR	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
CCL5	activates	gene	0.60
STAT3	regulates	gene	0.60
TNF	activates	gene	0.60
CXCL1	activates	gene	0.60
EGR1	protects_against	gene	0.60
CDC42	therapeutic_target	gene	0.60
PDGFRB	therapeutic_target	gene	0.60
CXCL8	activates	gene	0.60
HIPPO	activates	gene	0.60
ANG	activates	gene	0.60
TNF	regulates	gene	0.60
STAT3	causes	gene	0.60
YAP	regulates	gene	0.60
MST2	activates	gene	0.60
ST8SIA1	activates	gene	0.60
IL6	activates	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
ST3GAL2	activates	gene	0.60
CEBPA	protects_against	gene	0.60

Incoming (51)

Source	Relation	Type	Str
INS	regulates	gene	0.60
GATA3	activates	gene	0.60
TIMP1	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PTK2B	therapeutic_target	gene	0.60
EGR1	protects_against	gene	0.60
ATF3	protects_against	gene	0.60
BANG	regulates	gene	0.60
PPARG	protects_against	gene	0.60
NR3C1	protects_against	gene	0.60
CEBPA	protects_against	gene	0.60
NFKB1	protects_against	gene	0.60
STAT3	regulates	gene	0.60
TNF	regulates	gene	0.60
ESR1	regulates	gene	0.60
PI3K	activates	gene	0.60
TP53	regulates	gene	0.60
SRC	therapeutic_target	gene	0.60
GRN	regulates	gene	0.60
MST1	activates	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
AND	activates	gene	0.60
AQP3	activates	gene	0.60
AQP4	activates	gene	0.60
GATA1	activates	gene	0.60
APOA1	causes	gene	0.60
BECN1	causes	gene	0.60
FYN	causes	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICRORNAS	protects_against	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NF-KB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
ALS	regulates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
NR3C1	associated_with	gene	0.50
NFKB1	associated_with	gene	0.50
PPARG	associated_with	gene	0.50
EGR1	co_expressed_with	protein	0.50
ESR1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity