gene

HNRNPK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

39Outgoing

32Incoming

0Experiments

0Debates

Summary

HNRNPK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HNRNPK
Chromosome	9q21.32
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	51 kDa
Exons	17
Pathways	MAPK signaling, Wnt signaling
Ensembl ID	ENSG00000165119
GeneCards	HNRNPK
Human Protein Atlas	HNRNPK
Pre-mRNA processing	Alternative splicing regulation
mRNA stability	Binds to AU-rich elements (AREs) in 3' UTRs
Translation	Modulates translation initiation and elongation
Telomere maintenance	Associates with telomeric DNA
MAPK signaling	Participates in ERK and p38 pathways
Wnt signaling	Regulates β-catenin activity
Associated Diseases	Als
Interactions	ATG, AUTOPHAGY, CALCOCO2, CKB, EGR1, IFN
KG Connections	71 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HNRNPK["HNRNPK"]
    Ms{"Ms"}
    HNRNPK -->|"activates"| Ms
    Als{"Als"}
    HNRNPK -->|"activates"| Als
    HNRNPK -->|"associated with"| Als
    HNRNPK -->|"interacts with"| Als
    Aging{"Aging"}
    HNRNPK -->|"interacts with"| Aging
    HNRNPK -->|"interacts with"| Ms
    Hepatitis{"Hepatitis"}
    HNRNPK -->|"interacts with"| Hepatitis
    Carcinoma{"Carcinoma"}
    HNRNPK -->|"interacts with"| Carcinoma
    ALS{"ALS"}
    HNRNPK -->|"degrades"| ALS
    NDP52["NDP52"]
    HNRNPK -->|"activates"| NDP52
    HNRNPA1["HNRNPA1"]
    HNRNPK -->|"expressed in"| HNRNPA1
    Innate_Immunity(["Innate Immunity"])
    HNRNPK -->|"activates"| Innate_Immunity
    CKB["CKB"]
    CKB -->|"interacts with"| HNRNPK
    PTBP1["PTBP1"]
    PTBP1 -->|"expressed in"| HNRNPK
    TARDBP["TARDBP"]
    TARDBP -->|"expressed in"| HNRNPK
    CALCOCO2["CALCOCO2"]
    CALCOCO2 -->|"activates"| HNRNPK
    EGR1["EGR1"]
    EGR1 -->|"activates"| HNRNPK
    ATG["ATG"]
    ATG -->|"activates"| HNRNPK
    HNRNPA1 -->|"expressed in"| HNRNPK
    NDP52 -->|"activates"| HNRNPK
    ATG -->|"associated with"| HNRNPK
    CALCOCO2 -->|"associated with"| HNRNPK
    EGR1 -->|"associated with"| HNRNPK
    MYC["MYC"]
    MYC -->|"activates"| HNRNPK
    style HNRNPK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Als	interacts_with	disease	0.75
Hepatitis	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	degrades	disease	0.65
ALS	degrades	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
TARDBP	degrades	entity	0.60
Innate Immunity	associated_with	pathway	0.60
IFN	degrades	gene	0.60
RNA	degrades	gene	0.60
Ubiquitin	degrades	protein	0.60
CALCOCO2	degrades	gene	0.60
Ras	expressed_in	protein	0.60
TARDBP	expressed_in	gene	0.60
PTBP1	degrades	entity	0.60
Autophagy	interacts_with	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ATG	degrades	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
PTBP1	expressed_in	gene	0.60
Innate Immunity	degrades	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
NDP52	degrades	gene	0.60
LC3	interacts_with	gene	0.60
IFN	activates	gene	0.60
RNA	activates	gene	0.60
NDP52	activates	gene	0.60
ATG	activates	gene	0.60
HNRNPA1	expressed_in	gene	0.60
EGR1	activates	gene	0.60
PTBP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
Innate Immunity	activates	pathway	0.60
Autophagy	expressed_in	pathway	0.60
Proteins	associated_with	protein	0.50

Incoming (32)

Source	Relation	Type	Str
Pedv N Protein	degrades	protein	0.90
CKB	interacts_with	gene	0.80
HNRNPA1	expressed_in	gene	0.60
NDP52	activates	gene	0.60
ATG	activates	gene	0.60
ATG	associated_with	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
PTBP1	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
CALCOCO2	activates	gene	0.60
EGR1	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
EGR1	associated_with	gene	0.60
MYC	activates	gene	0.60
HNRNPA1	degrades	entity	0.60
CALCOCO2	associated_with	gene	0.60
IFN	degrades	gene	0.60
PARP1	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
PTBP1	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
CALCOCO2	degrades	gene	0.60
NPM1	interacts_with	gene	0.60
ATG	degrades	gene	0.60
RNA	degrades	gene	0.60
EGR1	degrades	gene	0.60
NDP52	degrades	gene	0.60
LC3	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
PTBP1	associated_with	gene	0.50
TARDBP	associated_with	gene	0.50
Autophagy	associated_with	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HNRNPK in their description or question text

No additional research found