concept

MAPK/ERK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK/ERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

4Outgoing

17Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MAPK/ERK
Key Genes/Proteins	AKT, BDNF, EGR1, ERBB2, ERK, integrins
Related Pathways	autophagy, PI3K/AKT

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK_ERK["MAPK/ERK"]
    MAPK_ERK -->|"activates"| EGR1["EGR1"]
    MAPK_ERK -->|"promotes"| neurodegeneration["neurodegeneration"]
    autophagy["autophagy"] -->|"activates"| MAPK_ERK
    SQSTM1_p62["SQSTM1/p62"] -->|"inhibits"| MAPK_ERK
    integrins["integrins"] -->|"activates"| MAPK_ERK
    reduced_loading["reduced loading"] -->|"inhibits"| MAPK_ERK
    ERK["ERK"] -->|"activates"| MAPK_ERK
    MAPK["MAPK"] -->|"activates"| MAPK_ERK
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| MAPK_ERK
    AKT["AKT"] -->|"inhibits"| MAPK_ERK

Outgoing (4)

Target	Relation	Type	Str
TARDBP	phosphorylates	protein	0.95
EGR1	activates	protein	0.90
neurodegeneration	promotes	process	0.80
Trk-B	activates	gene	0.80

Incoming (17)

Source	Relation	Type	Str
NPY	activates	protein	0.95
autophagy	activates	pathway	0.90
SQSTM1/p62	inhibits	protein	0.90
Heat Shock Response	activates	process	0.85
integrins	activates	protein	0.85
reduced loading	inhibits	phenotype	0.80
BDNF	activates	protein	0.80
AKT	inhibits	gene	0.50
PI3K	inhibits	gene	0.50
ERBB2	inhibits	gene	0.50
RAS	inhibits	gene	0.50
ERK	inhibits	gene	0.50
MAPK	inhibits	gene	0.50
PI3K/AKT	inhibits	pathway	0.50
ERK	activates	gene	0.50
MAPK	activates	gene	0.50
AUTOPHAGY	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK/ERK in their description or question text

No additional research found