concept

ARM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

13Hypotheses

0Analyses

0Outgoing

50Incoming

11Experiments

0Debates

Summary

ARM is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 50 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ARM
Key Genes/Proteins	ABCA1, ABCG1, ACTB, AKT, AMPK, APOA1
Linked Hypotheses	2 hypotheses

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARM["ARM"]
    PPAR["PPAR"] -->|"implicated in"| ARM
    CD2AP["CD2AP"] -->|"implicated in"| ARM
    HCN4["HCN4"] -->|"implicated in"| ARM
    HCN2["HCN2"] -->|"implicated in"| ARM
    HCN1["HCN1"] -->|"implicated in"| ARM
    SLC16A2["SLC16A2"] -->|"implicated in"| ARM
    SLC16A1["SLC16A1"] -->|"implicated in"| ARM
    GSS["GSS"] -->|"implicated in"| ARM
    CYP2E1["CYP2E1"] -->|"implicated in"| ARM
    IDH2["IDH2"] -->|"implicated in"| ARM
    HIF["HIF"] -->|"implicated in"| ARM
    TKT["TKT"] -->|"implicated in"| ARM

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (50)

Source	Relation	Type	Str
SOD1	associated_with	gene	0.56
PCSK9	associated_with	gene	0.56
HMGB2	associated_with	gene	0.56
NADH	implicated_in	gene	0.50
NAD	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
MCU	implicated_in	gene	0.50
P2RY12	implicated_in	gene	0.50
LC3	implicated_in	gene	0.50
APOA1	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
PI3K	implicated_in	gene	0.50
MAP1LC3	implicated_in	gene	0.50
ABCG1	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
LOX	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
AMPK	implicated_in	gene	0.50
AKT	implicated_in	gene	0.50
ABCA1	implicated_in	gene	0.50
ULK1	implicated_in	gene	0.50
LDL	implicated_in	gene	0.50
ATG5	implicated_in	gene	0.50
CERS2	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
AQP4	implicated_in	gene	0.50
UNC5B	implicated_in	gene	0.50
HSPA1A	implicated_in	gene	0.50
PARP1	implicated_in	gene	0.50
DNA	implicated_in	gene	0.50
PRMT5	implicated_in	gene	0.50
PRMT1	implicated_in	gene	0.50
PHGDH	implicated_in	gene	0.50
FASN	implicated_in	gene	0.50
EGR1	implicated_in	gene	0.50
KRAS	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
CD2AP	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
HIF	implicated_in	gene	0.50
TKT	implicated_in	gene	0.50
TIGAR	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	TREM2 in Alzheimer's Disease: Mechanisms
Multi-Modal Stress Response Harmonization	0.756	neurodegeneration	Digital biomarkers and AI-driven early d
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons
Pharmacologically Boost AQP4X Readthrough to Restore Perivas	0.650	neurodegeneration	How can AQP4 be effectively targeted the

Pharmacological Enhancement of APOE4 Glycosylation	0.622	neurodegeneration	APOE4 structural biology and therapeutic
Pharmacogenomic CNS Drug Optimization Platform	0.611	neurodegeneration	How do neurodegeneration gene expression
M1 Muscarinic Receptor Agonism as Pharmacological Exercise S	0.589	neurodegeneration	What are the specific circulating factor
Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) a	0.583	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha	0.578	neurodegeneration	How do different organelle-specific auto
Pharmacologic modulation of D2 autoreceptor-Gi/o signaling i	0.420	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
Exposure profile may matter more than nominal daily dose, bu	0.390	neurodegeneration	-
Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacolog	0.320	metabolomics	Metabolomic signatures of neurodegenerat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A
Gestational haloperidol exposure effects on hippocampal gene expressio	validation	schizophrenia	0.900	0.00	pregnant mice and offspring	proposed	N/A
Dual-luciferase assay for miR-137-3p target validation	exploratory	schizophrenia	0.800	0.00	cell culture system with dual-	proposed	N/A
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Experiment: Autoimmune Hypothesis Testing in AD	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Index	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,280,000
N-of-1 Clinical Trial Design for CBS/PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Experiment Scoring Methodology	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Genetic regulation of post-translational modification of two distinct proteins. [PMID:35332118]	Landini A, Trbojević-Akmačić I, Navarro	Nat Commun	2022	1
Divergent Golgi trafficking limits B cell-mediated IgG sialylation. [PMID:35726710]	Glendenning LM, Zhou JY, Reynero KM, Cob	J Leukoc Biol	2022	1
Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotei [PMID:32141499]	Huang G, Li Z, Li Y, Liu G, Sun S, Gu J,	Biochem J	2020	1
Methylation of HPA axis related genes in men with hypersexual disorder. [PMID:28319850]	Jokinen J, Boström AE, Chatzittofis A, C	Psychoneuroendocrinology	2017	1
Disease-associated glycans on cell surface proteins. [PMID:27131428]	Takahashi M, Kizuka Y, Ohtsubo K, Gu J,	Mol Aspects Med	2016	1
Development of alopecia areata is associated with higher central and peripheral [PMID:19020552]	Zhang X, Yu M, Yu W, Weinberg J, Shapiro	J Invest Dermatol	2009	1
Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways [PMID:41512596]	["Dhapola R", "Kumari S", "Sharma P", "P	Cytokine & growth factor revie	2026	0
Neurobiological and therapeutic landmarks of depression associated with Alzheime [PMID:40529210]	["Untu I", "Davidson M", "Stanciu G", "R	Frontiers in aging neuroscienc	2025	0
Neurobiological mechanisms and recent advances in drug-based therapeutics in dep [PMID:41205901]	["Ahmadnia H", "Abdollahzadeh R", "Hatam	Neuroscience	2025	0
Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of [PMID:40649806]	["Ricardi C", "Mazzierli A", "Guglielmo	International journal of molec	2025	0
A novel multi-target compound mitigates amyloid plaques, synaptic deficits, and [PMID:40770166]	["Lee Y", "Han S", "Lee J", "Cho Y", "Ki	Archives of pharmacal research	2025	0
Beyond Pulmonary Vein Reconnection: Exploring the Dynamic Pathophysiology of Atr [PMID:40363950]	["Vlachakis P", "Theofilis P", "Apostolo	Journal of clinical medicine	2025	0
Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative st [PMID:40712453]	["Liu T", "Kong X", "Qiao J", "Wei J"]	Redox biology	2025	0
Glucocorticoid treatment and adrenal suppression in children: current view and o [PMID:39352628]	["Improda N", "Chioma L", "Capalbo D", "	Journal of endocrinological in	2025	0
Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714]	Garton T, Gadani SP, Gill AJ, Calabresi	Neuron	2024	0
STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778]	Woo MS, Mayer C, Binkle-Ladisch L, Sonne	Cell	2024	0
Sex Differences in Stress Response: Classical Mechanisms and Beyond. [PMID:37855285]	["Hodes G", "Bangasser D", "Sotiropoulos	Current neuropharmacology	2024	0
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PMID:36917977]	Neel DV, Basu H, Gunner G, Bergstresser	Neuron	2023	0
Heat exposure intervention, anxiety level, and multi-omic profiles: A randomized [PMID:37871510]	["Fang W", "Liu L", "Yin B", "Ke L", "Su	Environment international	2023	0
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using Pa [PMID:35837482]	Pun FW, Liu BHM, Long X	Front Aging Neurosci	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARM in their description or question text

Pharmacological Enhancement of APOE4 Glycosylation

Score: 0.622 · neurodegeneration · 2026-04-02

## Mechanistic Overview Pharmacological Enhancement of APOE4 Glycosylation starts from the claim that modulating ST6GAL1

Pharmacogenomic CNS Drug Optimization Platform

Score: 0.611 · neurodegeneration · 2026-04-12

## **Molecular Mechanism and Rationale** The pharmacogenomic CNS drug optimization platform leverages fundamental diffe

M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute

Score: 0.589 · neurodegeneration · 2026-04-14

## Mechanistic Overview M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute starts from the claim that

Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) as repurposing probe

Score: 0.583 · neurodegeneration · 2026-04-21

## **Molecular Mechanism and Rationale** The P2RY12 receptor, a G-protein coupled receptor (GPCR) primarily known for i

NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy

Score: 0.578 · neurodegeneration · 2026-04-21

## **Molecular Mechanism and Rationale** The NAD+/SARM1 axis represents a critical metabolic checkpoint that coordinate

Pharmacologic modulation of D2 autoreceptor-Gi/o signaling in established PD mod

Score: 0.420 · neurodegeneration · 2026-04-25

Test whether carefully titrated D2-pathway modulation can normalize pathological autoreceptor signaling after alpha-synu

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of M

Score: 0.320 · metabolomics · 2026-04-25

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of Monocarboxylate Transporters

ARM