gene

NTRK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

0Experiments

0Debates

Summary

NTRK3 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, associated with, activates. Associated with ALS, Als, Breast Cancer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTRK3
Full Name	Neurotrophic Receptor Tyrosine Kinase 3
Chromosome	15q25.3
Protein Family	Trk family (NTRK1, NTRK2, NTRK3)
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	94 kDa
Amino Acids	843 aa
Exons	19
Pathways	PI3K, MAPK
UniProt ID	Q15006
NCBI Gene ID	4916
Ensembl ID	ENSG00000184348
OMIM	191316
GeneCards	NTRK3
Human Protein Atlas	NTRK3
Associated Diseases	Breast Cancer, Cancer, Carcinoma, Ms
Known Drugs/Compounds	dasatinib
Interactions	ABL1, ABL2, App, ASTROCYTES, BDNF, CALB1
KG Connections	118 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTRK3 — AlphaFold Q15006 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTRK3["NTRK3"]
    Leukemia{"Leukemia"}
    NTRK3 -->|"activates"| Leukemia
    Als{"Als"}
    NTRK3 -->|"activates"| Als
    Ms{"Ms"}
    NTRK3 -->|"associated with"| Ms
    Cancer{"Cancer"}
    NTRK3 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    NTRK3 -->|"associated with"| Carcinoma
    ALS{"ALS"}
    NTRK3 -->|"activates"| ALS
    CSF1R["CSF1R"]
    NTRK3 -->|"contributes to"| CSF1R
    PTK2B["PTK2B"]
    NTRK3 -->|"contributes to"| PTK2B
    ETV6["ETV6"]
    NTRK3 -->|"expressed in"| ETV6
    ABL1["ABL1"]
    NTRK3 -->|"contributes to"| ABL1
    PDGFRB["PDGFRB"]
    NTRK3 -->|"contributes to"| PDGFRB
    GENES["GENES"]
    NTRK3 -->|"activates"| GENES
    TYK2["TYK2"]
    TYK2 -->|"contributes to"| NTRK3
    PTK2B -->|"contributes to"| NTRK3
    IL7R["IL7R"]
    IL7R -->|"contributes to"| NTRK3
    JAK2["JAK2"]
    JAK2 -->|"contributes to"| NTRK3
    PDGFRB -->|"contributes to"| NTRK3
    ETV6 -->|"expressed in"| NTRK3
    ABL2["ABL2"]
    ABL2 -->|"contributes to"| NTRK3
    ABL1 -->|"contributes to"| NTRK3
    CSF1R -->|"contributes to"| NTRK3
    EPOR["EPOR"]
    EPOR -->|"contributes to"| NTRK3
    TSLP["TSLP"]
    TSLP -->|"contributes to"| NTRK3
    GENES -->|"activates"| NTRK3
    style NTRK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	causes	disease	0.65
Leukemia	activates	disease	0.65
Als	activates	disease	0.65
Breast Cancer	associated_with	disease	0.65
IL7R	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
PTK2B	contributes_to	gene	0.60
CDH1	causes	gene	0.60
PDGFRB	contributes_to	gene	0.60
JAK2	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
Bdnf	associated_with	protein	0.60
CANCER	associated_with	gene	0.60
CDH1	associated_with	gene	0.60
ETV6	associated_with	gene	0.60
TSLP	contributes_to	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
Rb	contributes_to	protein	0.60
Fus	expressed_in	protein	0.60
App	activates	protein	0.60
neurons	expressed_in	cell_type	0.60
AND	contributes_to	gene	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60
Raf	activates	protein	0.60
Pdgf	contributes_to	protein	0.60
ETV6	expressed_in	gene	0.60
ABL1	contributes_to	gene	0.60
GENES	activates	gene	0.60
EPOR	contributes_to	gene	0.60
ASTROCYTES	activates	gene	0.60
Mapk	activates	pathway	0.60
Neuron	associated_with	cell_type	0.60
Astrocyte	activates	cell_type	0.60
PTK2B	activates	entity	0.60
TYK2	activates	entity	0.60
PDGFRB	expressed_in	entity	0.60
EGR1	activates	gene	0.60
FOS	activates	gene	0.60
NTRK2	activates	gene	0.60
BDNF	associated_with	gene	0.60
GAD1	activates	gene	0.60
NTF3	associated_with	gene	0.60

Incoming (48)

Source	Relation	Type	Str
AND	associated_with	gene	0.60
TYK2	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
JAK2	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
S100B	activates	gene	0.60
ETV6	expressed_in	gene	0.60
ABL1	contributes_to	gene	0.60
ASTROCYTES	activates	gene	0.60
ABL2	contributes_to	gene	0.60
ETV6	causes	gene	0.60
GAD1	activates	gene	0.60
BDNF	associated_with	gene	0.60
GFAP	activates	gene	0.60
NTF3	associated_with	gene	0.60
FOS	activates	gene	0.60
PVALB	activates	gene	0.60
CALB2	activates	gene	0.60
EGR1	activates	gene	0.60
CALB1	activates	gene	0.60
NTRK2	activates	gene	0.60
EPOR	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
GENES	activates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
CSF1R	activates	entity	0.60
IL7R	activates	entity	0.60
JAK2	activates	entity	0.60
CSF1R	expressed_in	entity	0.60
JAK2	expressed_in	entity	0.60
FLT3	contributes_to	gene	0.60
ABL1	activates	gene	0.60
ABL2	activates	gene	0.60
CRLF2	activates	gene	0.60
EPOR	activates	gene	0.60
FLT3	activates	gene	0.60
ABL1	expressed_in	gene	0.60
ABL2	expressed_in	gene	0.60
EPOR	expressed_in	gene	0.60
dasatinib	targets	drug	0.60
BDNF	interacts_with	gene	0.50
NTF3	interacts_with	gene	0.50
PDGFRB	activates	gene	0.50
TYK2	activates	gene	0.50
PDGFRB	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NTRK3 in their description or question text

No additional research found