protein 1,108 words KG: EGR1PROTEIN
Contents

EGR1 Protein

🔬 Protein Info
Gene SymbolEGR1
Full NameEarly Growth Response 1
AliasesEarly Growth Response protein 1
Chromosome5q31
Protein TypeTranscription Factor
FunctionEGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight59.8 kDa
PathwaysMAPK
UniProt IDP18146
NCBI Gene ID1958
Ensembl IDENSG00000120738
OMIM129500
GeneCardsEGR1
Human Protein AtlasEGR1
Associated DiseasesAD, ALI, Als, Alzheimer, ARM
Known Drugs/Compoundsmetformin
InteractionsAGING, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections421 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (9)

Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Molecular docking validation of ginger-PRMT1 interactions
exploratory · proposed · Score: 0.80

Key Papers (1)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)