gene

CEBPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEBPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

137Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CCAAT/Enhancer Binding Protein Alpha - Transcription Factor in Neurodegeneration

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🧬 Gene Info

Gene Symbol	CEBPA
Aliases	CCAAT/Enhancer Binding Protein Alpha
Protein Type	Gene
Function	encodes a transcription factor belonging to the C/EBP family of basic leucine zipper (bZIP) proteins.
Primary Expression	Broad tissue distribution; high expression in liver, adipose tissue, and hematopoietic cells; moderate expression in brain (astrocytes, microglia, neu
Molecular Weight	42 kDa
Pathways	Apoptosis, Cholesterol
UniProt ID	P49715
NCBI Gene ID	1050
Ensembl ID	ENSG00000172270
OMIM	116897
GeneCards	CEBPA
Human Protein Atlas	CEBPA
Full name	CCAAT/Enhancer Binding Protein Alpha
Chromosomal locus	19q13.11
Associated Diseases	ALS, Alzheimer, Multiple Sclerosis, Parkinson
KG Connections	137 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CEBPA — AlphaFold P49715 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CEBPA Gene

gene · 1769 words

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Pathway Diagram

flowchart TD
    CEBPA["CEBPA"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"regulates"| Ms["Ms"]
    CEBPA["CEBPA"] -->|"therapeutic target"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"associated with"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"associated with"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"associated with"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"expressed in"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"expressed in"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"regulates"| ALS["ALS"]
    CEBPA["CEBPA"] -->|"regulates"| Alzheimer["Alzheimer"]
    style CEBPA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Multiple_Sclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
MIR34A	regulates	gene	0.85
HSPB1	regulates	gene	0.80
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
PARKINSON	expressed_in	gene	0.60
P53	regulates	protein	0.60
HSPA1A	associated_with	gene	0.60
ATF3	protects_against	gene	0.60
Nfkb	protects_against	protein	0.60
HSPB1	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
HSPB1	expressed_in	gene	0.60
Cholesterol	regulates	pathway	0.60
GENES	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
AND	protects_against	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
FLT3	associated_with	gene	0.60
WT1	associated_with	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
NME1	therapeutic_target	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D3	associated_with	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
EGR1	protects_against	entity	0.60
NR3C1	protects_against	entity	0.60
PPARG	protects_against	entity	0.60
Rb	expressed_in	protein	0.60
MICRORNAS	protects_against	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
HUB GENES	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
PARKINSON	therapeutic_target	gene	0.60

Incoming (60)

Source	Relation	Type	Str
NM1	upregulates	protein	0.90
MYO1C	upregulates	gene	0.85
Creatine Phosphate	upregulates	compound	0.85
PARKINSON	therapeutic_target	gene	0.60
WT1	expressed_in	gene	0.60
ERBB2	expressed_in	gene	0.60
HSPB1	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
AND	regulates	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
SPI1	regulates	gene	0.60
EPAS1	associated_with	gene	0.60
CACNG6	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
EGR1	protects_against	gene	0.60
ATF3	protects_against	gene	0.60
BANG	regulates	gene	0.60
PPARG	protects_against	gene	0.60
NR3C1	protects_against	gene	0.60
GATA2	protects_against	gene	0.60
TNF	regulates	gene	0.60
STAT3	regulates	gene	0.60
ESR1	regulates	gene	0.60
NFKB1	protects_against	gene	0.60
FOS	associated_with	gene	0.60
MYC	associated_with	gene	0.60
FOSB	expressed_in	gene	0.60
CAMK2G	expressed_in	gene	0.60
EGR1	associated_with	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
RNA	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
HSPA1A	expressed_in	gene	0.60
MICRORNAS	protects_against	gene	0.60
INS	regulates	gene	0.60
AND	protects_against	gene	0.60
NME1	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CACNA1E	associated_with	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
TP53	regulates	gene	0.60
TFE3	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CEBPA in their description or question text

No additional research found