gene 704 words KG: EGR1
Contents

EGR1 Gene

🧬 Gene Info
Gene SymbolEGR1
Full NameEarly Growth Response 1
AliasesEarly Growth Response protein 1
Chromosome5q31
Protein TypeTranscription Factor
FunctionEGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight59.8 kDa
PathwaysMAPK
UniProt IDP18146
NCBI Gene ID1958
Ensembl IDENSG00000120738
OMIM129500
GeneCardsEGR1
Human Protein AtlasEGR1
Associated DiseasesAD, ALI, Als, Alzheimer, ARM
Known Drugs/Compoundsmetformin
InteractionsAGING, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections415 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Arginine Methylation Enhancement Therapy
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (9)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Molecular docking validation of ginger-PRMT1 interactions
exploratory · proposed · Score: 0.80

See Also (9)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
Astrocytes
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

IGF1R activates EGR1
EGR1 regulates PDGF_BB
PRMT1 associated_with EGR1
PTBP1 activates EGR1
TARDBP activates EGR1
CALCOCO2 activates EGR1
EGR1 activates HNRNPK
EGR1 activates NDP52
EGR1 activates HNRNPA1
PDGFRB activates EGR1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.