gene

TREH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

179Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Trehalase - a glycogen hydrolase enzyme involved in trehalose metabolism, autophagy induction, and implicated in Alzheimer's disease, diabetes, and cellular stress resistance

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🧬 Gene Info

Gene Symbol	TREH
Full Name	Trehalase
Chromosome	11q23.3
Function	is a non-reducing disaccharide found in many organisms, where it serves as a protectant against various environmental stresses.
Primary Expression	the small intestine, kidney, liver, and brain
Subcellular Localization	the cytosol
Molecular Weight	65 kDa
Amino Acids	583 aa
Pathways	Autophagy, Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	[Q9NUH0](https://www.uniprot.org/uniprot/Q9NUH0)
Ensembl ID	ENSG00000143537
GeneCards	TREH
Human Protein Atlas	TREH
Membrane-bound trehalase	Attached to cell membranes via transmembrane domain
Soluble trehalase	Secreted or cytosolic localization
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, disease, Huntington, Neuroblastoma
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12, AUTOPHAGY
KG Connections	179 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TREH — Trehalase

gene · 2498 words

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Pathway Diagram

graph TD
    TREH["TREH"]
    TREH -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TREH -->|"activates"| ATG10["ATG10"]
    TREH -->|"activates"| Autophagy["Autophagy"]
    TREH -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    TREH -->|"activates"| ATG12["ATG12"]
    TREH -->|"activates"| TFEB["TFEB"]
    TREH -->|"activates"| CALCINEURIN["CALCINEURIN"]
    TREH -->|"activates"| GENES["GENES"]
    TREH -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    TREH -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    CALCINEURIN -->|"activates"| TREH
    ATG12 -->|"activates"| TREH
    TFEB -->|"activates"| TREH
    GENES -->|"activates"| TREH
    ATG10 -->|"activates"| TREH
    TREHALOSE["TREHALOSE"] -->|"activates"| TREH

Outgoing (102)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Huntington	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
CTSB	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
XPO1	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
Chaperone	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
MAP1LC3B	associated_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
BECN1	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
Huntington's disease	activates	disease	0.60
PPP3	associated_with	gene	0.60
Ras	associated_with	protein	0.60
Stem Cell	associated_with	pathway	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	activates	disease	0.60
Autophagy	activates	pathway	0.60
HUNTINGTON	associated_with	gene	0.60
Neuron	activates	cell_type	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
Parkinson's disease	activates	disease	0.60
DNA	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
Cathepsin	associated_with	protein	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Sod1	associated_with	pathway	0.60
GAPDH	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
RNA	associated_with	gene	0.60
STUB1	associated_with	gene	0.60

Incoming (77)

Source	Relation	Type	Str
PPP3	associated_with	gene	0.60
DNA	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
RNA	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	activates	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ATG10	activates	gene	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60
LAMP1	activates	entity	0.60
LAMP2A	activates	entity	0.60
LGALS3	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MCOLN1	activates	entity	0.60
MTOR	activates	entity	0.60
P62	activates	entity	0.60
PPARGC1A	activates	entity	0.60
PPP3CB	activates	entity	0.60
SOD1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STIP1	activates	entity	0.60
STUB1	activates	entity	0.60
TARDBP	activates	entity	0.60
TPP1	activates	entity	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREH in their description or question text

No additional research found