| Gene Symbol | BAG3 |
| Full Name | BCL-2-Associated Athanogene 3 |
| Chromosome | 10q25.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 57.5 kDa |
| Amino Acids | 575 aa |
| Exons | 4 |
| Pathways | Autophagy, Complement, Nf-Κb |
| GeneCards | BAG3 |
| Human Protein Atlas | BAG3 |
| Protein Quality Control | BAG3 helps maintain proteostasis by targeting misfolded proteins for degradation. |
| Cytoskeletal Organization | BAG3 interacts with the cytoskeleton, particularly Z-discs in muscle cells, where it helps maintain sarcomere integrity. |
| Anti-Apoptotic Signaling | Through interactions with Hsp70 and other proteins, BAG3 inhibits apoptosis. |
| Associated Diseases | Als, Alzheimer's disease, ALZHEIMERS_DISEASE, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis |
| Known Drugs/Compounds | rapamycin |
| Interactions | ALPHA_SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA |
| KG Connections | 415 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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