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gene 679 words KG: BAG3
Contents

BAG3 Gene

🧬 Gene Info
Gene SymbolBAG3
Full NameBCL2 Associated Athanogene 3
Chromosome10q25.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight57.5 kDa
Amino Acids575 aa
Exons4
PathwaysAutophagy, Complement, Nf-Κb
GeneCardsBAG3
Human Protein AtlasBAG3
Associated DiseasesAls, Alzheimer's disease, ALZHEIMERS_DISEASE, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis
Known Drugs/Compoundsrapamycin
InteractionsALPHA_SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA
KG Connections415 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Circadian Clock-Autophagy Synchronization
Score: 0.76CYP46A1 Overexpression Gene Therapy
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Temporal Decoupling via Circadian Clock Reset
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (8)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (12)

Astrocytes
cell · KG edge: activatesAmyotrophic Lateral Sclerosis
redirect · KG edge: associated_withApoptosis in Neurodegeneration
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesAstrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

BMAL1 regulates BAG3
BAG3 inhibits TAU
STIP1 associated_with BAG3
LGALS3 associated_with BAG3
HSPA8 associated_with BAG3
MCOLN1 associated_with BAG3
SQSTM1 associated_with BAG3
SOD1 associated_with BAG3
BCL2 associated_with BAG3
CTSB associated_with BAG3

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