Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASTROCYTE ACTIVATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ASTROCYTE ACTIVATION |
graph TD
ASTROCYTE_ACTIVATION["ASTROCYTE ACTIVATION"]
ASTROCYTE_ACTIVATION -->|"upregulates"| BAG3["BAG3"]
ASTROCYTE_ACTIVATION -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
Lactosylceramide["Lactosylceramide"] -->|"regulates"| ASTROCYTE_ACTIVATION
LacCer["LacCer"] -->|"regulates"| ASTROCYTE_ACTIVATION
BMAL1["BMAL1"] -->|"inhibits"| ASTROCYTE_ACTIVATION
GFAP["GFAP"] -.biomarker for.-> ASTROCYTE_ACTIVATION
B4GALT6["B4GALT6"] -->|"regulates"| ASTROCYTE_ACTIVATION
Microglia["Microglia"] -->|"activates"| ASTROCYTE_ACTIVATION
BMAL1_Deletion["BMAL1 Deletion"] -->|"causes"| ASTROCYTE_ACTIVATION| Target | Relation | Type | Str |
|---|---|---|---|
| BAG3 | upregulates | gene | 0.85 |
| BAG3 | activates | protein | 0.85 |
| Neuroinflammation | involved_in | process | 0.85 |
| Reactive gliosis | accompanies | process | 0.80 |
| glial scar formation | drives | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Lactosylceramide | regulates | compound | 0.95 |
| LacCer | regulates | compound | 0.95 |
| BMAL1 | inhibits | gene | 0.95 |
| GFAP | biomarker_for | protein | 0.92 |
| LCN2 | promotes | protein | 0.90 |
| 116B | inhibits | compound | 0.90 |
| BMAL1 | modulates | gene | 0.90 |
| B4GALT6 | regulates | gene | 0.90 |
| Microglia | activates | cell_type | 0.85 |
| BMAL1 Deletion | causes | phenotype | 0.85 |
| MAPK | activates | pathway | 0.83 |
| Microglia Activation | precedes | process | 0.80 |
| ALPHA-SYNUCLEIN | modulates | protein | 0.80 |
| CHI3L1 | regulates | gene | 0.80 |
| PPAR-γ Inhibition | inhibits | mechanism | 0.80 |
| NLRP3 inflammasome | promotes | pathway | 0.80 |
| amyloid-β plaques | drives | compound | 0.80 |
| ERK1/2 | mediates | pathway | 0.78 |
| C9orf72 Hexanucleotide Repeat Expansion | inhibits | mechanism | 0.75 |
| STAT3 | mediates | gene | 0.70 |
| NRF2 | inhibits | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Heterogeneous astrocyte activation states differentially imp | 0.640 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-08 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880] | Yogeshwar SM, Bartels F, Grüter T, Muñiz | Brain | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685] | Gasparini F, Valletta M, Vetrano DL, Ber | Neurology | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252] | Shin D, Lee S, Kim JP, Jang H, Yun J et | Nat Commun | 2026 | 0 |
| Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957] | Özkurt Ç, Kelicen-Uğur P | Biomarkers | 2026 | 0 |
| From scaffold to effector: reframing GFAP in neurodegeneration. [PMID:41775321] | Lu YH, Zhu XP, Li S, Zhang FN, Cai CB et | J Adv Res | 2026 | 0 |
| Translating neurofilament light chain testing into clinical practice: a multidis [PMID:41831326] | Furlan R, Di Sapio A, Ferraro D, Rossi E | Clin Chem Lab Med | 2026 | 0 |
| Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459] | Li S, Wei S, Wang L, Yu T, Wang H et al. | Int J Biol Macromol | 2026 | 0 |
| Impaired glymphatic function is associated with synaptic loss in cognitive impai [PMID:41454064] | He K, Wang J, Wu J, Chen X, Chen H, Li J | European journal of nuclear me | 2026 | 0 |
| Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284] | Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX, | Autophagy | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ASTROCYTE ACTIVATION in their description or question text
No additional research found