gene

ATG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 190 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG3
Full Name	Autophagy Related 3
Chromosome	3q13.11
Function	is an essential autophagy gene encoding a ubiquitin-like conjugating enzyme that plays a critical role in autophagosome formation[@mizushima2011].
Molecular Weight	~35 kDa
Amino Acids	314 amino acids
Exons	12
Pathways	Apoptosis, Autophagy, Car-T, Immunotherapy, Tdp-43
GeneCards	ATG3
Human Protein Atlas	ATG3
Associated Diseases	ALS, Inflammation, Ms, Osteoarthritis, Rheumatoid Arthritis
Interactions	ACHE, AGING, AND, APOPTOSIS, ARAF, ATG12
KG Connections	248 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATG3 Gene

gene · 1666 words

→

ATG3 Protein

protein · 1112 words

→

Pathway Diagram

graph TD
    ATG3["ATG3"] -->|"protects against"| CD19_CAR_T_cell_cytotoxicity["CD19 CAR-T cell cytotoxicity"]
    ATG3["ATG3"] -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG3["ATG3"] -->|"therapeutic target"| Als["Als"]
    ATG3["ATG3"] -->|"activates"| Cancer["Cancer"]
    ATG3["ATG3"] -->|"regulates"| Leukemia["Leukemia"]
    ATG3["ATG3"] -->|"regulates"| Cancer_1["Cancer"]
    CAT["CAT"] -->|"therapeutic target"| ATG3["ATG3"]
    ATG4B["ATG4B"] -->|"therapeutic target"| ATG3["ATG3"]
    TARDBP["TARDBP"] -->|"therapeutic target"| ATG3["ATG3"]
    ATG13["ATG13"] -->|"contributes to"| ATG3["ATG3"]
    style ATG3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
Ferroptosis	contributes_to	process	0.85
autophagy pathway	participates_in	pathway	0.80
ATG7	inhibits	gene	0.70
Autophagy	expressed_in	pathway	0.70
Autophagy	regulates	pathway	0.70
Als	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Osteoarthritis	associated_with	disease	0.65
Lymphoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	inhibits	disease	0.65
Pain	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Leukemia	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
FERROPTOSIS	contributes_to	phenotype	0.64
BECN1	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
NEURON	therapeutic_target	gene	0.60
LC3B	associated_with	gene	0.60
ALS	associated_with	disease	0.60
APOPTOSIS	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
T cells	expressed_in	cell_type	0.60
CRISPR-Cas	participates_in	pathway	0.60
AND	contributes_to	gene	0.60
TARDBP	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
NEURON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
LYSOSOME	activates	gene	0.60
BECN1	regulates	gene	0.60
ATG4B	inhibits	gene	0.60
CAT	inhibits	gene	0.60
CD19	regulates	gene	0.60
Ras	activates	protein	0.60

Incoming (89)

Source	Relation	Type	Str
LC3B	expressed_in	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
GENES	regulates	gene	0.70
ALS	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
LC3B	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
LIPOPHAGY	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
TNF-Α	regulates	gene	0.60
CANCER	regulates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ROS	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
IL-6	expressed_in	gene	0.60
ACHE	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
AGING	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
LC3B	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
MOTOR NEURONS	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
BECN1	associated_with	gene	0.60
CAT	therapeutic_target	gene	0.60
ATG4B	therapeutic_target	gene	0.60
TARDBP	therapeutic_target	gene	0.60
ATG13	contributes_to	gene	0.60
ATG5	contributes_to	gene	0.60
NCOA4	activates	gene	0.60
ATG7	contributes_to	gene	0.60
RAB7A	activates	gene	0.60
ATG4B	contributes_to	gene	0.60
CYCS	associated_with	gene	0.60
SOD1	inhibits	gene	0.60
P62	inhibits	gene	0.60
UBC	associated_with	gene	0.60
MTOR	activates	gene	0.60
ATG12	regulates	gene	0.60
EIF2A	activates	gene	0.60
CAT	regulates	gene	0.60
FGF18	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG3 in their description or question text

No additional research found