gene

SDHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SDHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

170Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for SDHA Gene - Succinate Dehydrogenase Complex Subunit A

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🧬 Gene Info

Gene Symbol	SDHA
Full Name	Succinate Dehydrogenase Complex Subunit A
Aliases	Page for SDHA Gene, Page for SDHA Protein
Chromosome	5p15.33
Protein Type	Enzyme
Function	SDHA is a catalytic subunit of succinate dehydrogenase (SDH), a heterotetrameric enzyme that functions in both the Krebs cycle (Complex II of the ETC).
Molecular Weight	73 kDa
Pathways	Proteasome
UniProt ID	P31040
NCBI Gene ID	6389
Ensembl ID	ENSG00000123594
GeneCards	SDHA
Human Protein Atlas	SDHA
Krebs Cycle	Catalyzes succinate to fumarate oxidation
Electron Transport Chain	Transfers electrons to ubiquinone
Associated Diseases	Parkinson
Interactions	aco2, ACO2, AGING, ATP, ATP5A1, BDNF
KG Connections	170 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SDHA — AlphaFold P31040 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SDHA["SDHA"]
    Parkinson{"Parkinson"}
    SDHA -->|"therapeutic target"| Parkinson
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    SDHA -->|"therapeutic target"| Oxidative_Phosphorylation
    Oxidative_Stress(["Oxidative Stress"])
    SDHA -->|"therapeutic target"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    SDHA -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| SDHA
    VDAC1["VDAC1"]
    VDAC1 -->|"expressed in"| SDHA
    HSPA9["HSPA9"]
    HSPA9 -->|"expressed in"| SDHA
    CYCS["CYCS"]
    CYCS -->|"expressed in"| SDHA
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| SDHA
    ACO2["ACO2"]
    ACO2 -->|"expressed in"| SDHA
    GLUD1["GLUD1"]
    GLUD1 -->|"therapeutic target"| SDHA
    SNCA["SNCA"]
    SNCA -->|"expressed in"| SDHA
    LRPPRC["LRPPRC"]
    LRPPRC -->|"therapeutic target"| SDHA
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic target"| SDHA
    NDUFS2["NDUFS2"]
    NDUFS2 -->|"therapeutic target"| SDHA
    NDUFS1["NDUFS1"]
    NDUFS1 -->|"therapeutic target"| SDHA
    style SDHA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (98)

Target	Relation	Type	Str
Parkinson	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cardiomyopathy	activates	disease	0.65
Als	regulates	disease	0.65
Diabetes	activates	disease	0.65
Parkinson	activates	disease	0.65
Stroke	regulates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
TFAM	expressed_in	gene	0.60
LONP1	expressed_in	gene	0.60
TNF	activates	gene	0.60
SIRT1	expressed_in	gene	0.60
VEGF	activates	gene	0.60
PINK1	activates	gene	0.60
OPA1	activates	gene	0.60
GPX1	activates	gene	0.60
MTOR	activates	gene	0.60
ACO2	expressed_in	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
VDAC1	expressed_in	gene	0.60
SNCA	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
OCLN	regulates	gene	0.60
CYCS	expressed_in	gene	0.60
UBC	regulates	gene	0.60
ZO1	regulates	gene	0.60
CLDN5, OCLN	regulates	gene	0.60
ACTB	regulates	gene	0.60
SNCA	targets	gene	0.60
VDAC1	targets	gene	0.60
SNCA	activates	gene	0.60
VDAC1	activates	gene	0.60
SNCA	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
TFAM	activates	gene	0.60
SUCLG1	interacts_with	gene	0.60
SIRT3	inhibits	gene	0.60
SIRT3	regulates	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
ATP	activates	gene	0.60
Proteasome	regulates	pathway	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
TNF-Α	activates	gene	0.60

Incoming (72)

Source	Relation	Type	Str
ATP	inhibits	gene	0.60
OCLN	regulates	gene	0.60
ACO2	targets	gene	0.60
CYCS	targets	gene	0.60
HSPA9	targets	gene	0.60
ACO2	activates	gene	0.60
CYCS	activates	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	activates	gene	0.60
GENES	regulates	gene	0.60
RNA	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
HUB GENES	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
IMMUNE INFILTRATION	activates	gene	0.60
VDAC1	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
ACO2	expressed_in	gene	0.60
GLUD1	therapeutic_target	gene	0.60
SNCA	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
COX4I1	expressed_in	gene	0.60
MLKL	expressed_in	gene	0.60
RIPK1	expressed_in	gene	0.60
RIPK3	expressed_in	gene	0.60
COX4I1	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
CLDN5	regulates	gene	0.60
UBC	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ZO1	regulates	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60
ATP5A1	interacts_with	gene	0.60
MDH2	interacts_with	gene	0.60
NDUFS3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SDHA in their description or question text

No additional research found