gene

HOMER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HOMER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

1Hypotheses

0Analyses

43Outgoing

27Incoming

0Experiments

0Debates

Summary

HOMER1 encodes Homer scaffold proteins regulating synaptic plasticity and metabotropic glutamate receptor signaling

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🧬 Gene Info

Gene Symbol	HOMER1
Full Name	Homer Scaffold Protein 1
Chromosome	5q14.1
Protein Family	Homer scaffolding proteins
UniProt ID	Q86YM7
NCBI Gene ID	9456
Ensembl ID	ENSG00000159307
OMIM	604798
GeneCards	HOMER1
Human Protein Atlas	HOMER1
Associated Diseases	Als, Hallucination, levodopa adverse drug reactions, Ms, Parkinson
Known Drugs/Compounds	levodopa, rapamycin
Interactions	AMPK, ATG5, ATM, ATR, CASP3, CTSB
KG Connections	70 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HOMER1 — AlphaFold Q86YM7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HOMER1 Gene

gene · 1513 words

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Pathway Diagram

graph TD
    HOMER1["HOMER1"]
    Ms{"Ms"}
    HOMER1 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    HOMER1 -->|"associated with"| Parkinson
    Als{"Als"}
    HOMER1 -->|"associated with"| Als
    ALS{"ALS"}
    HOMER1 -->|"associated with"| ALS
    COMT["COMT"]
    HOMER1 -->|"associated with"| COMT
    SRC["SRC"]
    HOMER1 -->|"associated with"| SRC
    UBC["UBC"]
    HOMER1 -->|"associated with"| UBC
    SNCA["SNCA"]
    HOMER1 -->|"associated with"| SNCA
    DRD2["DRD2"]
    HOMER1 -->|"associated with"| DRD2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    HOMER1 -->|"associated with"| PARKINSON_S_DISEASE
    SLC6A3["SLC6A3"]
    HOMER1 -->|"associated with"| SLC6A3
    CAMK2A["CAMK2A"]
    HOMER1 -->|"associated with"| CAMK2A
    DRD2 -->|"associated with"| HOMER1
    FYN["FYN"]
    FYN -->|"associated with"| HOMER1
    SRC -->|"associated with"| HOMER1
    CAMK2A -->|"associated with"| HOMER1
    SNCA -->|"associated with"| HOMER1
    SLC6A3 -->|"associated with"| HOMER1
    UBC -->|"associated with"| HOMER1
    COMT -->|"associated with"| HOMER1
    GENES["GENES"]
    GENES -->|"associated with"| HOMER1
    PARKINSON_S_DISEASE -->|"associated with"| HOMER1
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| HOMER1
    AND["AND"]
    AND -->|"associated with"| HOMER1
    style HOMER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

Target	Relation	Type	Str
Hallucination	associated_with	phenotype	0.85
hallucination	biomarker_for	phenotype	0.80
levodopa adverse drug reactions	associated_with	phenotype	0.75
Parkinson	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
TRPML1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ROS	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
COMT	associated_with	gene	0.60
SRC	associated_with	gene	0.60
UBC	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
FYN	associated_with	gene	0.60
ULK1	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GENES	associated_with	gene	0.60
App	associated_with	protein	0.60
LC3B	activates	gene	0.60
RILP	activates	gene	0.60
SLC2A4	activates	gene	0.60
TSC2	activates	gene	0.60
MTHFR	interacts_with	gene	0.60
JNK1	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MAP2	activates	gene	0.60
MAPK14	activates	gene	0.60
MAPK8	activates	gene	0.60
MCOLN1	activates	gene	0.60
neurons	expressed_in	cell_type	0.55
SNCA	co_expressed_with	gene	0.50
SLC6A3	co_expressed_with	gene	0.50

Incoming (27)

Source	Relation	Type	Str
UBC	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
FYN	associated_with	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ATG5	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
CASP3	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
DYNLL1	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GAPDH	activates	gene	0.60
AMPK	activates	gene	0.60
GFP	activates	gene	0.60
GLUT4	activates	gene	0.60
rapamycin	targets	drug	0.60
GENES	associated_with	gene	0.60
COMT	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
levodopa	targets	drug	0.60
DRD2	interacts_with	gene	0.50
FYN	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
circHomer1a Restoration as Neuroprotective Strategy in Synap	0.540	neurodegeneration	Gap 006 analysis (archived stub)

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HOMER1 in their description or question text

No additional research found