protein

COMT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

293Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

COMT is a protein involved in neurodegeneration research. Key relationships include: associated with, expressed in, co discussed. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 173 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	COMT
Full Name	Catechol-O-Methyltransferase
Chromosome	22
Protein Type	Enzyme
Function	The COMT gene encodes catechol-O-methyltransferase, an enzyme that catalyzes the methylation of catecholamines using S-adenosylmethionine (SAM) as a methyl donor.
Primary Expression	peripheral tissues
Molecular Weight	30 kDa
Pathways	autophagy pathway
UniProt ID	P21964
Ensembl ID	ENSG00000093072
OMIM	116790
GeneCards	COMT
Human Protein Atlas	COMT
Associated Diseases	age-related cognitive decline, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	levodopa, LEVODOPA
Interactions	ANKK1, APOE, BDNF, CYP2C18, CYP3A5, DAT
KG Connections	293 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: COMT — AlphaFold P21964 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    COMT["COMT Gene
Catechol-O-methyltransferase"]
    COMT_protein["COMT Protein
Dopamine Metabolizing
Enzyme"]
    dopamine["Dopamine
Neurotransmitter"]
    cognitive_function["Cognitive Function
Executive Control
Working Memory"]
    
    SLC6A3["DAT1 (SLC6A3)
Dopamine Transporter"]
    SLC6A2["NET (SLC6A2)
Norepinephrine Transporter"]
    ADRA2A["ADRA2A
Alpha-2A Adrenergic
Receptor"]
    HTR2C["HTR2C
Serotonin 2C Receptor"]
    
    Alzheimer["Alzheimer's Disease
Cognitive Decline"]
    Parkinson["Parkinson's Disease
Motor and Cognitive
Dysfunction"]
    ALS["ALS
Motor Neuron
Degeneration"]
    Depression["Depression
Mood Disorder"]
    Dementia["Dementia
Progressive
Cognitive Loss"]
    
    COMT -->|"encodes"| COMT_protein
    COMT_protein -->|"metabolizes"| dopamine
    dopamine -->|"regulates"| cognitive_function
    
    COMT -->|"variants affect"| Alzheimer
    COMT -->|"variants affect"| Parkinson
    COMT -->|"contributes to"| ALS
    COMT -->|"associated with"| Depression
    COMT -->|"therapeutic target"| Dementia
    
    SLC6A3 -->|"interacts with"| dopamine
    SLC6A2 -->|"modulates"| COMT_protein
    ADRA2A -->|"influences"| cognitive_function
    HTR2C -->|"cross-regulates"| dopamine
    
    cognitive_function -->|"impaired in"| Alzheimer
    cognitive_function -->|"affected in"| Parkinson
    dopamine -->|"depleted in"| Parkinson
    
    style COMT fill:#006494
    style COMT_protein fill:#006494
    style dopamine fill:#4a1a6b
    style cognitive_function fill:#1b5e20
    style SLC6A3 fill:#4a1a6b
    style SLC6A2 fill:#4a1a6b
    style ADRA2A fill:#4a1a6b
    style HTR2C fill:#4a1a6b
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Depression fill:#ef5350
    style Dementia fill:#ef5350

Outgoing (198)

Target	Relation	Type	Str
Levodopa-Induced Dyskinesia	risk_factor_for	phenotype	0.95
Levodopa Response	biomarker_for	phenotype	0.90
Parkinson Disease	associated_with	disease	0.90
Signal Transmission	involved_in	process	0.90
Metabolite Levels	regulates	phenotype	0.85
Cognition	regulates	phenotype	0.85
Levodopa-induced dyskinesia	risk_factor_for	phenotype	0.85
Chemical synaptic transmission	modulates	process	0.82
Cognitive Aging	risk_factor_for	phenotype	0.80
Parkinson's disease	associated_with	disease	0.80
dopamine	degrades	entity	0.80
DRD2	interacts_with	gene	0.80
glioma	associated_with	disease	0.80
hyperuricemia	inhibits	disease	0.80
Parkinson's Disease	implicated_in	disease	0.75
anxiety	modulates	phenotype	0.75
Als	associated_with	disease	0.75
Parkinson'S Disease	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
cognitive_function	associated_with	phenotype	0.72
COMT_protein	encodes	protein	0.72
DBH	transports	gene	0.70
DRD2	expressed_in	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.70
NEURONS	regulates	cell_type	0.70
SLC6A3	expresses	gene	0.70
Parkinson's disease	biomarker_for	disease	0.70
age-related cognitive decline	associated_with	phenotype	0.70
ALS	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Hypertension	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
dopamine	regulates	protein	0.64
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60

Incoming (95)

Source	Relation	Type	Str
PARKINSON	associated_with	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
levodopa	targets	drug	0.70
LEVODOPA	activates	drug	0.70
PARKINSON	therapeutic_target	gene	0.60
MAPK	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
CHAT	co_discussed	gene	0.60
SLC6A4	expressed_in	gene	0.60
ANXIETY	associated_with	gene	0.60
NR3C1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
SLC6A3	causes	gene	0.60
LRRK2	associated_with	gene	0.60
SNCA	causes	gene	0.60
MAPT	causes	gene	0.60
DICER1	expressed_in	gene	0.60
AND	associated_with	gene	0.60
CADM1	implicated_in	gene	0.60
AND	causes	gene	0.60
INSULIN RESISTANCE	associated_with	gene	0.60
CYP2C18	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
ABCG2	associated_with	entity	0.60
ANKK1	activates	gene	0.60
CYP1A2	associated_with	gene	0.60
ANKK1	interacts_with	gene	0.60
ANKK1	associated_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
UGT3A1	associated_with	gene	0.60
AKT1	expressed_in	gene	0.60
MTOR	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
GBA3	associated_with	gene	0.60
BCHE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COMT in their description or question text

No additional research found