gene

FYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FYN
Full Name	FYN Proto-Oncogene, Src Family Tyrosine Kinase
Aliases	Fyn Tyrosine Kinase
Chromosome	6q21.
Protein Type	Receptor
Function	encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary Expression	T-cells, NK cells, and other immune cells
Molecular Weight	60 kDa
Amino Acids	537 aa
Pathways	Akt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt ID	P39687
NCBI Gene ID	2534
Ensembl ID	ENSG00000110881
OMIM	137025
GeneCards	FYN
Human Protein Atlas	FYN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	438 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FYN — AlphaFold P39687 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

gene · 725 words

→

FYN Protein (Fyn Tyrosine Kinase)

protein · 1173 words

→

Pathway Diagram

graph TD
    FYN["FYN"]
    FYN -->|"activates"| STAT3["STAT3"]
    FYN -->|"upregulates"| IL12A["IL12A"]
    FYN -->|"regulates"| Kv1_3["Kv1.3"]
    FYN -->|"causes"| dopaminergic_neuron["dopaminergic neuron"]
    FYN -->|"activates"| neuroinflammation["neuroinflammation"]
    FYN -->|"activates"| microglia_activation["microglia activation"]
    FYN -->|"regulates"| Schizophrenia["Schizophrenia"]
    FYN -->|"regulates"| Epilepsy["Epilepsy"]
    FYN -->|"regulates"| Alzheimer["Alzheimer"]
    FYN -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| FYN
    LCK["LCK"] -->|"activates"| FYN
    PKC["PKC"] -->|"activates"| FYN
    SRC["SRC"] -->|"activates"| FYN
    PI3K["PI3K"] -->|"regulates"| FYN
    GENES["GENES"] -->|"activates"| FYN
    NRF2["NRF2"] -->|"activates"| FYN
    CD36["CD36"] -->|"inhibits"| FYN
    AKT["AKT"] -->|"regulates"| FYN
    BACH1["BACH1"] -->|"activates"| FYN

Outgoing (316)

Target	Relation	Type	Str
Dopaminergic Neuron Loss	causes	phenotype	0.95
STAT3	activates	gene	0.95
Microglia Activation	causes	phenotype	0.90
Mitochondrial Aggregation	causes	phenotype	0.90
Parkinson'S Disease	risk_factor_for	disease	0.90
RELN	interacts_with	entity	0.90
KV1.3	modulates	gene	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
NEURONAL MIGRATION	involved_in	entity	0.85
KCNA3	modulates	gene	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
PARKINSON'S DISEASE	associated_with	disease	0.85
KV1.3	upregulates	gene	0.85
NFE2L2	phosphorylates	protein	0.85
KV1.3	phosphorylates	protein	0.80
IL12A	upregulates	gene	0.80
Alzheimer	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Aging	expressed_in	disease	0.75
TAU	associated_with	gene	0.70
TREM2	associated_with	gene	0.70
Parkinson's disease	associated_with	disease	0.70
dopaminergic neuron	causes	cell_type	0.70
Apoptosis	activates	pathway	0.70
ALZHEIMER	associated_with	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
PARKINSON	associated_with	gene	0.70
neuroinflammation	activates	process	0.70
Kv1.3	regulates	protein	0.70
microglia activation	activates	process	0.70
MICROGLIA	activates	gene	0.70
Cancer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Hepatitis	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	degrades	disease	0.65
Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
Parkinson	activates	disease	0.65
NEURON	inhibits	cell_type	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
Autism	regulates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Depression	regulates	disease	0.65

Incoming (123)

Source	Relation	Type	Str
Apoer2	activates	protein	0.85
GSK3B	phosphorylates	gene	0.85
ABETA	activates	protein	0.80
APP	associated_with	gene	0.70
BIN1	interacts_with	gene	0.70
APOE	expresses	gene	0.70
CLU	expresses	gene	0.70
APOPTOSIS	activates	gene	0.70
DOPAMINERGIC	inhibits	cell_type	0.65
AD	activates	gene	0.60
AΒ	interacts_with	gene	0.60
SRC	activates	gene	0.60
AKT	regulates	gene	0.60
JUN	regulates	gene	0.60
AD	interacts_with	gene	0.60
APP	causes	gene	0.60
AUTOPHAGY	inhibits	pathway	0.60
CAMK2A	associated_with	gene	0.60
AKT	activates	gene	0.60
SRC	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
PI3K	regulates	gene	0.60
NRF2	activates	gene	0.60
CD36	inhibits	gene	0.60
AΒ	activates	gene	0.60
BACH1	activates	gene	0.60
CUL3	regulates	gene	0.60
UBC	associated_with	gene	0.60
AD	inhibits	gene	0.60
NRF2	phosphorylates	gene	0.60
LCK	activates	gene	0.60
CASS4	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
KEAP1	activates	gene	0.60
PKC	activates	gene	0.60
AΒ	inhibits	gene	0.60
DRD2	associated_with	gene	0.60
TNFA	causes	gene	0.60
STAT3	causes	gene	0.60
IL1B	causes	gene	0.60
BACH1	phosphorylates	entity	0.60
AKT	phosphorylates	entity	0.60
IL12A	causes	gene	0.60
HOMER1	associated_with	gene	0.60
CUL3	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AURKA	associated_with	gene	0.60
PI3K	phosphorylates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FYN in their description or question text

No additional research found