gene

DRD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

792Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

DRD2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiac. Connected to 173 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DRD2
Full Name	Dopamine Receptor D2
Chromosome	11q23.2
Protein Type	Gpcr
Target Class	Gpcr
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Small molecule agonist or antagonist modulating dopamine signaling
Primary Expression	Striatum, Substantia nigra, Pituitary, Cortex
Druggability	High (0.90)
Clinical Stage	Approved
Pathways	PI3K
UniProt ID	P14416
NCBI Gene ID	1819
Ensembl ID	ENSG00000149295
GeneCards	DRD2
Human Protein Atlas	DRD2
Associated Diseases	Addiction, Als, Alzheimer, Autism, Bipolar
Known Drugs/Compounds	D-520, L-DOPA, levodopa, quinpirole, UNC9995
Interactions	ACHE, Actin, ADRA1A, ADRA1B, Akt, AKT
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Pharmacologic modulation of D2 autoreceptor-Gi/o s
KG Connections	792 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — DRD2 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6CM4 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P14416 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DRD2 Gene

gene · 1116 words

→

Dopamine Receptor D2 (DRD2)

protein · 694 words

→

Pathway Diagram

graph TD
    DRD2["DRD2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    DRD2["DRD2"] -->|"interacts"| SNCA["SNCA"]
    DRD2["DRD2"] -->|"co discussed"| CHR2["CHR2"]
    DRD2["DRD2"] -->|"co discussed"| CLOCK["CLOCK"]
    DRD2["DRD2"] -->|"co discussed"| CRH["CRH"]
    DRD2["DRD2"] -->|"co discussed"| BDNF["BDNF"]
    SNCA_1["SNCA"] -->|"interacts"| DRD2["DRD2"]
    FOXP3["FOXP3"] -->|"co discussed"| DRD2["DRD2"]
    TNFA["TNFA"] -->|"co discussed"| DRD2["DRD2"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| DRD2["DRD2"]
    style DRD2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (532)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
locomotor suppression	mediates	phenotype	0.90
Dyskinesia	associated_with	phenotype	0.90
Motor Fluctuations	associated_with	phenotype	0.90
dyskinesia	biomarker_for	phenotype	0.90
GI/O signaling	activates	pathway	0.90
levodopa adverse drug reactions	mediates	phenotype	0.85
astrocytes	expressed_in	cell_type	0.80
NLRP3	interacts_with	gene	0.80
dopamine receptor	regulates	receptor	0.80
ACOD1	regulates	gene	0.80
β-arrestin2	interacts_with	protein	0.80
Depression	implicated_in	disease	0.80
p11	binds	protein	0.80
basal_ganglia_circuit	modulates	pathway	0.80
Motor fluctuations	risk_factor_for	phenotype	0.75
Als	therapeutic_target	disease	0.75
TNF	targets	gene	0.70
VEGF	targets	gene	0.70
NEURONS	expressed_in	cell_type	0.70
STING	targets	gene	0.70
SLC6A3	expresses	gene	0.70
HSP90	targets	gene	0.70
STING	regulates	gene	0.70
NOTCH	transports	gene	0.70
PDGF	expresses	gene	0.70
TNF	activates	gene	0.70
dopamine receptor	interacts_with	receptor	0.70
schizophrenia	interacts_with	disease	0.70
dopamine receptor	activates	receptor	0.70
Sepsis	implicated_in	disease	0.70
Glutamatergic Transmission	regulates	biological_process	0.70
DOPAMINE	causes	phenotype	0.70
M1 Macrophages	associated_with	cell_type	0.70
Parkinson'S Disease	risk_factor_for	disease	0.70
NF-κB Signaling	inhibits	pathway	0.70
Parkinson Disease	associated_with	disease	0.70
MYD88	associated_with	protein	0.70
Chronic Sleep Deprivation	contributes_to	biological_process	0.70
Astrocyte Inflammatory Injury	associated_with	biological_process	0.70
dopamine receptor	inhibits	receptor	0.70
oxidative stress response	participates_in	pathway	0.70
Complement	therapeutic_target	pathway	0.70
dopamine receptor	associated_with	receptor	0.70
Bipolar	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Schizophrenia	regulates	disease	0.65

Incoming (260)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Spnphilin	interacts_with	protein	0.95
quinpirole	targets	drug	0.95
Spnphilin	promotes	protein	0.90
h-072b2f5d	targets	hypothesis	0.90
D-520	binds	drug	0.90
RGS6	modulates	protein	0.90
Spnphilin	therapeutic_target	protein	0.85
UNC9995	activates	compound	0.80
levodopa	targets	drug	0.80
COMT	interacts_with	gene	0.80
ANKK1	interacts_with	gene	0.80
DOPAMINERGIC	activates	cell_type	0.70
APP	targets	gene	0.70
CHOLINERGIC	activates	cell_type	0.70
DRD1	activates	gene	0.70
ACHE	targets	gene	0.70
ASTROCYTE	expressed_in	cell_type	0.70
DRD1	expresses	gene	0.70
DOPAMINERGIC	inhibits	cell_type	0.70
COMT	expressed_in	gene	0.70
ACHE	inhibits	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.70
ALPHA-SYNUCLEIN	interacts_with	protein	0.70
L-DOPA	protects_against	drug	0.70
NEURONS	produces	cell_type	0.65
ALPHA-SYNUCLEIN	associated_with	concept	0.65
DRD1	associated_with	gene	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
GSH	regulates	gene	0.60
INS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ACHE	biomarker_for	gene	0.60
AUTOPHAGY	activates	pathway	0.60
CHOLINERGIC	enhances	cell_type	0.60
GENES	interacts_with	gene	0.60
AND	expressed_in	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
GPNMB	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
AND	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
GENETIC LOCI	associated_with	gene	0.60
JUN	activates	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pharmacologic modulation of D2 autoreceptor-Gi/o signaling i	0.420	neurodegeneration	Does RGS6 upregulation or D2 autorecepto

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning DRD2 in their description or question text

No additional research found