gene

SLC6A3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

317Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SLC6A3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, transports, co discussed. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 200 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC6A3
Chromosome	5p15.33
Protein Type	Transporter
Function	encodes a transmembrane solute carrier in the SLC6 family.
Molecular Weight	79 kDa
Pathways	Akt, Cell Cycle, Dopamine Biosynthesis, Dopaminergic Synapse Function, Pi3K
GeneCards	SLC6A3
Human Protein Atlas	SLC6A3
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety
Known Drugs/Compounds	levodopa
Interactions	Actin, ALDH1A1, ALZHEIMER, ASTROCYTE, COMT, DNA
KG Connections	317 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC6A3 Gene

gene · 2629 words

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SLC6A3 Protein

protein · 808 words

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Pathway Diagram

flowchart TD
    SLC6A3["SLC6A3
(Dopamine Transporter)"]
    
    DA_Reuptake["Dopamine Reuptake
 and Clearance"]
    DA_Dysfunction["Dopaminergic
Dysfunction"]
    
    PD["Parkinson's Disease"]
    AD["Alzheimer's Disease"]
    ALS["Amyotrophic Lateral
Sclerosis"]
    HD["Huntington's Disease"]
    MS["Multiple Sclerosis"]
    Depression["Depression"]
    Dementia["Dementia"]
    
    SLC6A4["SLC6A4
(Serotonin Transporter)"]
    ABCB1["ABCB1
(P-glycoprotein)"]
    CYP3A4["CYP3A4
(Drug Metabolism)"]
    
    Epigenetic["Epigenetic
Regulation"]
    Therapeutic["Therapeutic
Intervention"]
    
    Neuroinflammation["Neuroinflammation"]
    Motor_Deficits["Motor Deficits"]
    Cognitive_Decline["Cognitive Decline"]
    
    SLC6A3 -->|"regulates"| DA_Reuptake
    DA_Reuptake -->|"dysfunction"| DA_Dysfunction
    
    SLC6A3 -->|"activates"| PD
    SLC6A3 -->|"protects_against"| PD
    SLC6A3 -->|"associated_with"| AD
    SLC6A3 -->|"activates"| ALS
    SLC6A3 -->|"protects_against"| ALS
    SLC6A3 -->|"associated_with"| HD
    SLC6A3 -->|"regulates"| MS
    SLC6A3 -->|"associated_with"| Depression
    SLC6A3 -->|"therapeutic_target"| Dementia
    
    DA_Dysfunction -->|"contributes_to"| Motor_Deficits
    DA_Dysfunction -->|"leads_to"| Cognitive_Decline
    DA_Dysfunction -->|"promotes"| Neuroinflammation
    
    SLC6A3 -->|"interacts_with"| SLC6A4
    SLC6A3 -->|"associated_with"| ABCB1
    SLC6A3 -->|"associated_with"| CYP3A4
    
    Epigenetic -->|"regulates"| SLC6A3
    SLC6A3 -->|"therapeutic_target"| Therapeutic
    
    style SLC6A3 fill:#006494
    style DA_Reuptake fill:#1b5e20
    style Therapeutic fill:#1b5e20
    style PD fill:#ef5350
    style AD fill:#ef5350
    style ALS fill:#ef5350
    style HD fill:#ef5350
    style MS fill:#ef5350
    style Depression fill:#ef5350
    style Dementia fill:#ef5350
    style DA_Dysfunction fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style SLC6A4 fill:#4a1a6b
    style ABCB1 fill:#4a1a6b
    style CYP3A4 fill:#4a1a6b
    style Epigenetic fill:#4a1a6b
    style Motor_Deficits fill:#5d4400
    style Cognitive_Decline fill:#5d4400

Outgoing (181)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC6A3	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Parkinson'S Disease	associated_with	disease	0.95
Levodopa Response	biomarker_for	phenotype	0.90
Parkinson's Disease	associated_with	disease	0.90
Dopamine Biosynthesis	involved_in	pathway	0.90
Dopaminergic Synapse Function	regulates	pathway	0.85
STING	protects_against	gene	0.70
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Als	inhibits	disease	0.65
Depression	associated_with	disease	0.65
Als	protects_against	disease	0.65
Huntington	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	interacts_with	disease	0.65
Prion	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Prion Disease	associated_with	disease	0.65
Pi3K	associated_with	pathway	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
Epigenetic	interacts_with	pathway	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
CYP3A5	associated_with	gene	0.60
Dopaminergic	activates	cell_type	0.60

Incoming (136)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SLC6A3	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
levodopa	targets	drug	0.85
DOPAMINERGIC	regulates	cell_type	0.70
DRD2	expresses	gene	0.70
NEURONS	regulates	cell_type	0.70
COMT	expresses	gene	0.70
ABCG2	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
PI3K	regulates	gene	0.60
TLR4	associated_with	gene	0.60
AKT	regulates	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
NDUFA9	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER'S	associated_with	disease	0.60
HUNTINGTON'S	associated_with	disease	0.60
PRION DISEASE	associated_with	disease	0.60
GENES	associated_with	gene	0.60
ABCB1	transports	gene	0.60
SLC6A4	transports	gene	0.60
CYP3A4	transports	gene	0.60
CYP1A2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
MAO	associated_with	gene	0.60
NEURON	regulates	cell_type	0.60
ABCB1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC6A3 in their description or question text

No additional research found