concept

POLR2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POLR2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

1Analyses

9Outgoing

10Incoming

0Experiments

1Debates

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💡 Concept Info

Name	POLR2A
Key Genes/Proteins	ACTB, ATL1, CDK9, COL4A1, GAPDH, GNAO1

Pathway Diagram

graph TD
    POLR2A[POLR2A]
    POLR2A -->|drives| dilncRNA[dilncRNA]
    POLR2A -->|activates| DNA_damage_response[DNA damage response]
    POLR2A -->|regulates| SDHA[SDHA]
    POLR2A -->|regulates| UBC[UBC]
    POLR2A -->|data_in| benchmark_ot_ad_answer_key_POL[benchmark_ot_ad_answer_key:POLR2A]
    MED1[MED1] -->|interacts| POLR2A
    CDK9[CDK9] -->|interacts| POLR2A
    ACTB[ACTB] -->|regulates| POLR2A
    GAPDH[GAPDH] -->|regulates| POLR2A
    benchmark_ot_ad_answer_key_POL -->|data_in| POLR2A

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:POLR2A	data_in	dataset_row	0.00
dilncRNA	drives	process	0.95
DNA damage response	activates	process	0.85
dilncRNA_synthesis	catalyzes	process	0.70
UBC	regulates	gene	0.60
SATB2	associated_with	gene	0.60
SLC16A2	associated_with	gene	0.60
SPAST	associated_with	gene	0.60
SDHA	regulates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:POLR2A	data_in	dataset_row	0.00
MED1	interacts_with	protein	0.85
CDK9	interacts_with	protein	0.85
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ATL1	associated_with	gene	0.60
COL4A1	associated_with	gene	0.60
GNAO1	associated_with	gene	0.60
PDHX	associated_with	gene	0.60
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do dilncRNAs specifically drive molecular crowding and phase separation of D

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

closed · Rounds: 7 · Score: 0.90 · 2026-04-10