gene

UBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
2Hypotheses
0Analyses
11Outgoing
6Incoming
1Experiments
0Debates

Summary

UBB is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Inflammation, Osteoarthritis. Connected to 18 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info
Gene SymbolUBB
Full NameUbiquitin B
Protein TypeLigase
FunctionUBB produces polyubiquitin chains that are processed into单体 ubiquitin
PathwaysMitophagy
Ensembl IDENSG00000104140
GeneCardsUBB
Human Protein AtlasUBB
Protein degradationUbiquitin tags proteins for proteasomal or lysosomal degradation<sup>[1]</sup>
Signal transductionUbiquitin serves as a signaling molecule
DNA repairUbiquitin participates in DNA damage response
EndocytosisUbiquitin marks membrane proteins for endocytosis
Quality controlUbiquitin targets misfolded and damaged proteins
Associated Diseasesneurodegeneration
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

UBB — Ubiquitin B

gene · 592 words

TUBB — Tubulin Beta Class I

gene · 3103 words

TUBB2A — Tubulin Beta 2A Class IIa

gene · 2613 words

TUBB2B — Tubulin Beta 2B Class IIb

gene · 2334 words

TUBB1 — Tubulin Beta 1

gene · 1634 words

TUBB2B Protein

protein · 1592 words

Pathway Diagram

graph TD
    UBB["UBB"]
    neurodegeneration{"neurodegeneration"}
    UBB -->|"implicated_in"| neurodegeneration
    UBC["UBC"]
    UBB -->|"regulates"| UBC
    GENES["GENES"]
    UBB -->|"therapeutic_target"| GENES
    LC3["LC3"]
    UBB -->|"regulates"| LC3
    MAP1LC3B["MAP1LC3B"]
    UBB -->|"regulates"| MAP1LC3B
    TOMM40["TOMM40"]
    UBB -->|"regulates"| TOMM40
    ATG12["ATG12"]
    UBB -->|"regulates"| ATG12
    ULK1["ULK1"]
    UBB -->|"regulates"| ULK1
    Osteoarthritis{"Osteoarthritis"}
    UBB -->|"therapeutic_target"| Osteoarthritis
    Inflammation{"Inflammation"}
    UBB -->|"therapeutic_target"| Inflammation
    Oxidative_Stress["Oxidative Stress"]
    UBB -->|"therapeutic_target"| Oxidative_Stress
    Mitophagy["Mitophagy"]
    UBB -->|"regulates"| Mitophagy
    GFP["GFP"]
    GFP -->|"therapeutic_target"| UBB
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| UBB
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic_target"| UBB
    CSNK2B["CSNK2B"]
    CSNK2B -->|"regulates"| UBB
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic_target"| UBB
    TOMM20["TOMM20"]
    TOMM20 -->|"therapeutic_target"| UBB
    style UBB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (11)

TargetRelationTypeStr
Osteoarthritistherapeutic_targetdisease0.65
Inflammationtherapeutic_targetdisease0.65
GENEStherapeutic_targetgene0.60
Oxidative Stresstherapeutic_targetpathway0.60
Mitophagyregulatespathway0.60

Incoming (6)

SourceRelationTypeStr
CSNK2Bregulatesgene0.60
TOMM20therapeutic_targetgene0.60
GFPtherapeutic_targetgene0.60
MITOPHAGYregulatesgene0.60
OXIDATIVE STRESStherapeutic_targetgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Focused Ultrasound with Microbubble Contrast Agents for Anti 0.736 neurodegeneration Blood-brain barrier antibody transport m
Focused Ultrasound with Microbubble Contrast Agents 0.684 drug delivery Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Epigenetic clocks association with brain aging patterns in older women exploratory cognitive impairment and demen 0.900 0.00 human patients proposed N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Multiple Sclerosis Pathology. [PMID:29358320] Lassmann H Cold Spring Harbor perspective 2018 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBB in their description or question text

No additional research found