gene

MDM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MDM2 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 373 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MDM2
Full Name	MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase
Chromosome	12q15
Protein Type	Ligase
Function	MDM2 is a RING-finger E3 ubiquitin ligase with multiple functions:
Primary Expression	neurons and glia - Higher expression in cortex and hippocampus - Regulated by neuronal activity
Molecular Weight	55 kDa
Amino Acids	491 aa
Pathways	NF-κB
UniProt ID	Q00978
NCBI Gene ID	4193
Ensembl ID	ENSG00000135679
OMIM	164785
GeneCards	MDM2
Human Protein Atlas	MDM2
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	Pmiγ, PMIγ
Interactions	AGING, AKT, AMBRA1, AMPK, AND, APOPTOSIS
KG Connections	528 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MDM2 — AlphaFold Q00978 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MDM2 Gene

gene · 543 words

→

MDM2 Protein

protein · 583 words

→

Pathway Diagram

graph TD
    MDM2["MDM2"]
    MDM2 -->|"inhibits"| Tumor["Tumor"]
    MDM2 -->|"inhibits"| Ms["Ms"]
    MDM2 -->|"target for"| Cancer["Cancer"]
    MDM2 -->|"target for"| Fibrosis["Fibrosis"]
    MDM2 -->|"target for"| Als["Als"]
    MDM2 -->|"regulates"| Glioblastoma["Glioblastoma"]
    BCL2["BCL2"] -->|"inhibits"| MDM2
    BCL2_FAMILY["BCL2 FAMILY"] -->|"inhibits"| MDM2
    AKT["AKT"] -->|"target for"| MDM2
    CASP3["CASP3"] -->|"target for"| MDM2
    PI3K["PI3K"] -->|"target for"| MDM2
    MAPK3["MAPK3"] -->|"target for"| MDM2
    JUN["JUN"] -->|"target for"| MDM2
    GENES["GENES"] -->|"target for"| MDM2

Outgoing (328)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Apoptosis	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Cancer	activates	disease	0.95
P53	associated_with	protein	0.95
TP53	inhibits	gene	0.92
p53	regulates	entity	0.90
cancer	associated_with	disease	0.90
p53	interacts_with	protein	0.90
TP53	interacts_with	gene	0.90
Tumor	activates	disease	0.85
Tumor	inhibits	disease	0.85
carcinogenesis	promotes	process	0.85
Als	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Aging	therapeutic_target	disease	0.85
Als	inhibits	disease	0.85
GENES	activates	gene	0.80
P53	inhibits	gene	0.80
DNA	activates	gene	0.80
MITOCHONDRIA	activates	gene	0.80
CANCER	activates	gene	0.80
Senescence	regulates	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Tumor	regulates	disease	0.75
Cancer	regulates	disease	0.75
immunity	regulates	process	0.75
Als	regulates	disease	0.75
Parkinson	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Cancer	inhibits	disease	0.75
Autophagy	activates	pathway	0.70
DNA	regulates	gene	0.70
Apoptosis	inhibits	pathway	0.70
Wnt	activates	pathway	0.70
Cell Cycle	inhibits	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
GENES	inhibits	gene	0.70
Apoptosis	regulates	pathway	0.70
Chaperone	therapeutic_target	pathway	0.70
P53	interacts_with	gene	0.70
Ferroptosis	activates	pathway	0.70
MYC	regulates	gene	0.70
Senescence	causes	disease	0.65
Als	causes	disease	0.65
Carcinoma	activates	disease	0.65
Ms	causes	disease	0.65

Incoming (200)

Source	Relation	Type	Str
P53	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
Pmiγ	binds	compound	0.90
PMIγ	binds	drug	0.90
P53	regulates	gene	0.90
ribosomal proteins	activates	protein	0.80
TP53	associated_with	gene	0.80
TP53	inhibits	gene	0.80
P53	inhibits	gene	0.80
ribosomal protein	interacts_with	protein	0.75
ERK	activates	gene	0.70
P53	therapeutic_target	gene	0.70
FERROPTOSIS	activates	gene	0.70
ROS	activates	gene	0.70
BAX	activates	gene	0.70
PARKINSON	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
NEURODEGENERATION	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
PTEN	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
TP53	therapeutic_target	gene	0.70
BAK	causes	gene	0.60
BCL2	inhibits	gene	0.60
BCL2	therapeutic_target	gene	0.60
FOS	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
BAX	expressed_in	gene	0.60
FYN	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
HSP90AB1	expressed_in	gene	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
AMBRA1	activates	gene	0.60
AKT	activates	gene	0.60
BAD	activates	gene	0.60
ULK1	activates	gene	0.60
CD4	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
GBM	regulates	gene	0.60
STAT3	regulates	gene	0.60
BRCA1	regulates	gene	0.60
BID	associated_with	gene	0.60
BCL2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.937

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning MDM2 in their description or question text

No additional research found