gene 1,362 words KG: TAX1BP1
Contents

TAX1BP1 Gene

🧬 Gene Info
Gene SymbolTAX1BP1
Chromosome7p15.2
Protein TypeReceptor
FunctionMitophagy: Recognizes ubiquitinated damaged mitochondria through its UBZ domain
Primary Expressionvarious tissues with particularly high expression in immune cells and the brain
Molecular Weight90 kDa
Amino Acids789 aa
Exons14
PathwaysNF-κB
Ensembl IDENSG00000133107
GeneCardsTAX1BP1
Human Protein AtlasTAX1BP1
LIR motif (LC3-interacting region)For autophagy receptor function
Coiled-coil domainsMediate protein-protein interactions
Multiple UBDsUbiquitin-binding domains throughout
Associated DiseasesAD, ALI, Als, Alzheimer, AMI
InteractionsABCD3, ACTB, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections752 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Amyotrophic Lateral Sclerosis
redirect · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ACTB interacts_with TAX1BP1
OPTN interacts_with TAX1BP1
ULK1 interacts_with TAX1BP1
SMCR8 interacts_with TAX1BP1
CALCOCO2 interacts_with TAX1BP1
LC3 interacts_with TAX1BP1
BECN1 interacts_with TAX1BP1
C9ORF72 interacts_with TAX1BP1
NBR1 interacts_with TAX1BP1
G3BP1 interacts_with TAX1BP1

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