gene

RAF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RAF1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, interacts with. Associated with Aging, Als, Anxiety. Connected to 128 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAF1
Full Name	RAF1 proto-oncogene, serine/threonine kinase
Chromosome	3p25.2
Protein Type	Kinase
Function	encodes a 648-amino acid serine/threonine protein kinase with a molecular mass of approximately 72.
Primary Expression	brain tissue
Amino Acids	648 aa
Pathways	MAPK
UniProt ID	[P04049](https://www.uniprot.org/uniprot/P04049)
Ensembl ID	ENSG00000132155
OMIM	164760
GeneCards	RAF1
Human Protein Atlas	RAF1
Associated Diseases	Als, Ms, Tumor
Interactions	ACVR1, AKT, APOPTOSIS, CBL, CDC42, CREB
KG Connections	167 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

c-Raf Protein (RAF1)

protein · 1548 words

→

RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)

gene · 1374 words

→

Pathway Diagram

graph TD
    RAF1["RAF1"]
    RAF1 -->|"regulates"| Ms["Ms"]
    RAF1 -->|"regulates"| Stroke["Stroke"]
    RAF1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    RAF1 -->|"target for"| Diabetes["Diabetes"]
    RAF1 -->|"target for"| Obesity["Obesity"]
    RAF1 -->|"target for"| Als["Als"]
    RAF1 -->|"target for"| Hypertension["Hypertension"]
    RAF1 -->|"target for"| Ischemia["Ischemia"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| RAF1
    E2F1["E2F1"] -->|"regulates"| RAF1
    P53["P53"] -->|"regulates"| RAF1
    MYC["MYC"] -->|"regulates"| RAF1
    DIABLO["DIABLO"] -->|"regulates"| RAF1
    EGF["EGF"] -->|"activates"| RAF1
    ERK1["ERK1"] -->|"activates"| RAF1
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| RAF1
    MDM2["MDM2"] -->|"activates"| RAF1
    PI3K["PI3K"] -->|"target for"| RAF1

Outgoing (99)

Target	Relation	Type	Str
Mapk	activates	pathway	0.90
Mapk	therapeutic_target	pathway	0.70
Ms	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Stroke	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Epilepsy	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Anxiety	treats	disease	0.65
Depression	treats	disease	0.65
Tumor	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Calcium Signaling	treats	pathway	0.60
Camp Signaling	treats	pathway	0.60
GENES	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
KRAS	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
RAS	associated_with	gene	0.60
Synaptic Plasticity	associated_with	pathway	0.60
IL-1	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Cytokine	therapeutic_target	protein	0.60
MAPK signaling	participates_in	pathway	0.60
P38	regulates	gene	0.60
DYRK1A	regulates	gene	0.60
SMAC	regulates	gene	0.60
AIF	regulates	gene	0.60
ESR1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60

Incoming (68)

Source	Relation	Type	Str
SUST	associated_with	gene	0.70
IL-17	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
EPILEPSY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
EGF	activates	gene	0.60
ERK1	activates	gene	0.60
MDM2	activates	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
RXRA	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
MDM2	associated_with	gene	0.60
RELA	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
PRKACA	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
PIK3CA	interacts_with	gene	0.60
RANKINGS	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
RHOA	interacts_with	gene	0.60
TRAF2	interacts_with	gene	0.60
TRAF6	interacts_with	gene	0.60
TGFBR1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
BCL2L1	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
ANGPT1	associated_with	gene	0.60
RHOA	associated_with	gene	0.60
ERK1	expressed_in	gene	0.60
SCN8A	activates	gene	0.60
BIRC5	therapeutic_target	gene	0.60
NRAS	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
CHUK	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
HMOX1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAF1 in their description or question text

No additional research found