gene

E2F1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

1Analyses

50Outgoing

29Incoming

0Experiments

1Debates

Summary

E2F1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Als, Cancer. Connected to 75 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	E2F1
Chromosome	20q11.22
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	proliferating neural precursors - Differentiated neurons: Low expression - Glia: Variable expression - Developmental: High during neurogen
Molecular Weight	47 kDa
Exons	9 coding exons
Pathways	Apoptosis, Autophagy, Cell Cycle
Ensembl ID	ENSG00000101412
GeneCards	E2F1
Human Protein Atlas	E2F1
Location	Chromosome 20q11.22
Gene Length	~11 kb
Alternative Splicing	Multiple isoforms
Associated Diseases	cerebral_ischemia-reperfusion_injury
Interactions	AKT, AND, APOPTOSIS, App, APP, APP/PS1
KG Connections	126 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

E2F1 Gene

gene · 725 words

→

E2F1 Protein

protein · 612 words

→

Pathway Diagram

graph TD
    E2F1["E2F1"]
    RAB37["RAB37"]
    E2F1 -->|"activates"| RAB37
    Ms{"Ms"}
    E2F1 -->|"activates"| Ms
    Als{"Als"}
    E2F1 -->|"regulates"| Als
    E2F1 -->|"activates"| Als
    E2F1 -->|"expressed in"| Als
    Tumor{"Tumor"}
    E2F1 -->|"expressed in"| Tumor
    Cancer{"Cancer"}
    E2F1 -->|"activates"| Cancer
    E2F1 -->|"activates"| Tumor
    E2F1 -->|"therapeutic target"| Cancer
    E2F1 -->|"therapeutic target"| Tumor
    E2F1 -->|"interacts with"| Tumor
    E2F1 -->|"regulates"| Ms
    E2F7["E2F7"]
    E2F7 -->|"activates"| E2F1
    E2F8["E2F8"]
    E2F8 -->|"activates"| E2F1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| E2F1
    ATM["ATM"]
    ATM -->|"activates"| E2F1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| E2F1
    style E2F1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (97)

Target	Relation	Type	Str
RAB37	activates	protein	0.90
endocycle	regulates	process	0.90
genome ploidy	upregulates	phenotype	0.85
G2/M transcriptional program	drives	pathway	0.80
CDK5	regulates	gene	0.80
DRP1	regulates	gene	0.80
neuron	causes	cell_type	0.80
cerebral_ischemia-reperfusion_injury	implicated_in	disease	0.80
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
CANCER	activates	gene	0.70
Stroke	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Colorectal Cancer	activates	disease	0.65
GENES	activates	gene	0.60
Cell Cycle	inhibits	pathway	0.60
Glycolysis	activates	pathway	0.60
DNA	inhibits	gene	0.60
DNA	regulates	gene	0.60
HK2	activates	gene	0.60
PDK3	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
APP/PS1	activates	gene	0.60
ENO1	activates	gene	0.60
Autophagy	regulates	pathway	0.60
P53	therapeutic_target	gene	0.60
MYC	activates	gene	0.60
Mitosis	activates	pathway	0.60
JNK	regulates	gene	0.60
PDK1	activates	gene	0.60
P53	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
stroke	inhibits	disease	0.60

Incoming (29)

Source	Relation	Type	Str
MYC	activates	gene	0.60
ENO1	activates	gene	0.60
MYC	regulates	gene	0.60
UCHL1	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
E2F2	activates	gene	0.60
ERK1	regulates	gene	0.60
CDK5	activates	gene	0.60
CDK5	phosphorylates	gene	0.60
DRP1	phosphorylates	gene	0.60
DRP1	activates	gene	0.60
LDHA	activates	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
GLUT1	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
AND	regulates	gene	0.60
C-MYC	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
E2F3	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
DNA	regulates	gene	0.60
E2F7	activates	gene	0.60
E2F8	activates	gene	0.60
ATM	activates	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific transcription factors mediate MAPT suppression during proteostati

neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.624

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which specific transcription factors mediate MAPT suppression during proteostati

active · Rounds: 4 · Score: 0.66 · 2026-04-25

Related Research

Hypotheses and analyses mentioning E2F1 in their description or question text

No additional research found