Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SUMF1 |
| Full Name | Sulfatase Modifying Factor 1 |
| Aliases | Page for SUMF1 Protein |
| Chromosome | 2q33.1 |
| Function | The SUMF1 protein, also known as formylglycine-generating enzyme (FGE), catalyzes the conversion of a conserved cysteine residue to formylglycine (FGly) in the active site of all sulfatases. |
| Primary Expression | Brain, Liver, Kidney, Lung |
| Molecular Weight | 42 kDa |
| Amino Acids | 345 aa |
| Exons | 9 |
| Pathways | oxidative stress response |
| UniProt ID | Q8IWU6 |
| NCBI Gene ID | 285362 |
| Ensembl ID | ENSG00000144455 |
| OMIM | 272300 |
| GeneCards | SUMF1 |
| Human Protein Atlas | SUMF1 |
| Associated Diseases | Multiple Sulfatase Deficiency |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SUST["SUST"]
GPR91["GPR91"]
SUST -->|"associated with"| GPR91
PP2C["PP2C"]
SUST -->|"associated with"| PP2C
HGF["HGF"]
SUST -->|"associated with"| HGF
MET["MET"]
SUST -->|"associated with"| MET
LZTR1["LZTR1"]
SUST -->|"associated with"| LZTR1
MAP2K1["MAP2K1"]
SUST -->|"associated with"| MAP2K1
RAF1["RAF1"]
SUST -->|"associated with"| RAF1
TP53["TP53"]
SUST -->|"associated with"| TP53
neurodegeneration["neurodegeneration"]
SUST -->|"implicated in"| neurodegeneration
style SUST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion | 0.808 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
| Microglia and complement sustain post-Aβ neurodegeneration a | 0.690 | neurodegeneration | Does tau dendritic missorting persist in |
| Chronic cGAS/STING Hyperactivation Drives Progressive Neurod | 0.661 | neuroinflammation | How does chronic cGAS/STING activation d |
| 5-HT2A/C Silencing Enables Sustained BDNF-TrkB Signaling for | 0.545 | - | What is the minimum effective dose of tr |
| Reactive astrocyte glutamate-handling failure sustains dendr | 0.490 | neurodegeneration | Does tau dendritic missorting persist in |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SUST in their description or question text
No additional research found