gene

RHOA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHOA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

361Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RHOA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RHOA
Full Name	Ras Homolog Family Member A
Chromosome	3p21.31
Function	encodes a small GTP-binding protein that functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state.
Molecular Weight	~22 kDa
Amino Acids	191 aa
Pathways	Akt, Angiogenesis, Apoptosis, Complement, Egfr Signaling
UniProt ID	[P61586](https://www.uniprot.org/uniprotkb/P61586/entry)
Ensembl ID	ENSG00000167553
GeneCards	RHOA
Human Protein Atlas	RHOA
Associated Diseases	Alzheimer, cancer, Dementia, Lung Cancer, Ms, neurodevelopmental disorders
Interactions	ACVR1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections	357 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RHOA Gene — Ras Homolog Family Member A

gene · 2670 words

→

Pathway Diagram

graph TD
    RHOA["RHOA"] -->|"activates"| Aging["Aging"]
    RHOA["RHOA"] -->|"activates"| Ms["Ms"]
    RHOA["RHOA"] -->|"activates"| Als["Als"]
    RHOA["RHOA"] -->|"activates"| Osteoporosis["Osteoporosis"]
    RHOA["RHOA"] -->|"regulates"| Alzheimer["Alzheimer"]
    RHOA["RHOA"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    EPHB4["EPHB4"] -->|"activates"| RHOA["RHOA"]
    ARF1["ARF1"] -.->|"inhibits"| RHOA["RHOA"]
    APP_PS1["APP/PS1"] -->|"regulates"| RHOA["RHOA"]
    P62["P62"] -->|"regulates"| RHOA["RHOA"]
    style RHOA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (246)

Target	Relation	Type	Str
Alzheimer's disease	associated_with	disease	0.85
autism spectrum disorder	associated_with	disease	0.75
Als	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
osteoblast	involved_in	cell_type	0.75
neurodevelopmental disorders	implicated_in	disease	0.70
Alzheimer	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Osteoporosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
ALS	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Dementia	causes	disease	0.65
Alzheimer	causes	disease	0.65
Vascular Dementia	causes	disease	0.65
Autism	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Gastric Cancer	activates	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Aging	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Nephropathy	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Autism	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65

Incoming (115)

Source	Relation	Type	Str
ARHGEF2	activates	gene	0.90
Icariin	upregulates	compound	0.85
P75NTR	activates	protein	0.80
EPHB4	regulates	gene	0.80
P75NTR	activates	gene	0.60
TRKB	activates	gene	0.60
AKT	activates	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
HSPA4	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
ENO1	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
APP/PS1	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
LYSOSOMAL BIOGENESIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AGING	expressed_in	gene	0.60
COMPLEMENT	activates	gene	0.60
DEMENTIA	causes	gene	0.60
PRRG4	activates	gene	0.60
ARF1	inhibits	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
BNIP3	regulates	gene	0.60
RAC1	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
BDNF	activates	gene	0.60
JNK	activates	gene	0.60
TP53	activates	gene	0.60
PKC	activates	gene	0.60
BMAL1	inhibits	gene	0.60
OVERVIEW	regulates	gene	0.60
EPHB4	expressed_in	entity	0.60
ARF1	activates	entity	0.60
GIT1	activates	gene	0.60
EGFR	associated_with	gene	0.60
APP	inhibits	gene	0.60
CDC42	inhibits	gene	0.60
AND	inhibits	gene	0.60
MAPK	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity