gene

CDKN1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

33Outgoing

17Incoming

0Experiments

0Debates

Summary

CDKN1B (p27/Kip1) is a cyclin-dependent kinase inhibitor that regulates G1/S cell cycle transition. It plays critical roles in neurogenesis, neuronal migration, and synaptic plasticity. Dysregulation is implicated in Alzheimer's disease, Parkinson's disease, and cancer.

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🧬 Gene Info

Gene Symbol	CDKN1B
Full Name	Cyclin-Dependent Kinase Inhibitor 1B
Aliases	p27/Kip1
Protein Type	Kinase
Function	is a member of the CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors.
Amino Acids	198 aa
Ensembl ID	ENSG00000100994
GeneCards	CDKN1B
Human Protein Atlas	CDKN1B
Apoptosis regulation	Interaction with ASK1 and modulation of JNK signaling
Cytoskeletal organization	Interaction with RhoA pathway affecting cell migration
Transcriptional regulation	Association with various transcription factors
Associated Diseases	Lupus
Interactions	APP, BCL2L1, CD44, CTNNB1, CXCR4, HMGB1
KG Connections	50 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

gene · 1693 words

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Pathway Diagram

graph TD
    CDKN1B["CDKN1B (p27/Kip1)"]
    
    %% Cell cycle regulation
    CDKN1B -->|"inhibits"| CellCycle["Cell Cycle Progression"]
    CellCycle -->|"dysregulation leads to"| Neurodegeneration["Neuronal Death"]
    
    %% Autophagy pathway - key for neurodegeneration
    CDKN1B -->|"regulates"| MTORC1["mTORC1 Complex"]
    MTORC1 -->|"inhibits"| AutophagyInit["Autophagy Initiation"]
    AutophagyInit -->|"activates"| ATG7["ATG7"]
    AutophagyInit -->|"activates"| ATG5["ATG5"]
    ATG7 -->|"forms complex"| LC3["LC3-II Formation"]
    ATG5 -->|"contributes to"| LC3
    LC3 -->|"promotes"| AutophagosomeForm["Autophagosome Formation"]
    
    %% Autophagy regulation genes
    BECN1["BECN1 (Beclin-1)"] -->|"initiates"| AutophagyInit
    DRAM1["DRAM1"] -->|"enhances"| AutophagosomeForm
    RUBCN["RUBCN"] -->|"regulates"| AutophagosomeForm
    
    %% Pathological connections
    LRRK2["LRRK2"] -->|"disrupts"| AutophagyInit
    AutophagosomeForm -->|"clears aggregates"| ProteinAggregates["Protein Aggregates"]
    ProteinAggregates -->|"accumulation causes"| Neurodegeneration
    
    %% Therapeutic implications
    CTSB["CTSB (Cathepsin B)"] -->|"degrades aggregates"| ProteinAggregates
    
    %% Styling
    style CDKN1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style AutophagyInit fill:#1b5e20,stroke:#333
    style AutophagosomeForm fill:#1b5e20,stroke:#333
    style LC3 fill:#1b5e20,stroke:#333
    style CTSB fill:#1b5e20,stroke:#333
    style BECN1 fill:#4a1a6b,stroke:#333
    style ATG7 fill:#4a1a6b,stroke:#333
    style ATG5 fill:#4a1a6b,stroke:#333
    style DRAM1 fill:#4a1a6b,stroke:#333
    style MTORC1 fill:#4a1a6b,stroke:#333
    style LRRK2 fill:#ef5350,stroke:#333
    style Neurodegeneration fill:#ef5350,stroke:#333
    style ProteinAggregates fill:#ef5350,stroke:#333
    style CellCycle fill:#7d4200,stroke:#333

Outgoing (33)

Target	Relation	Type	Str
Lupus	associated_with	disease	0.65
CXCR4	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
IGF1	interacts_with	gene	0.60
LAMP1	interacts_with	gene	0.60
TFRC	interacts_with	gene	0.60
CTNNB1	targets	gene	0.60
CXCR4	targets	gene	0.60
HMGB1	targets	gene	0.60
IGF1	targets	gene	0.60
LAMP1	targets	gene	0.60
TFRC	targets	gene	0.60
MTORC1	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
DNA	associated_with	gene	0.60
IFN	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
CTNNB1	interacts_with	gene	0.60
Adaptive Immunity	associated_with	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
ATG7	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
DRAM1	associated_with	gene	0.60
CTSB	therapeutic_target	gene	0.60

Incoming (17)

Source	Relation	Type	Str
APP	interacts_with	gene	0.60
BCL2L1	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
APP	targets	gene	0.60
BCL2L1	targets	gene	0.60
CD44	targets	gene	0.60
GENES	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ATG16L2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
BIRC5	therapeutic_target	gene	0.60
RAF1	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
PRKCD	therapeutic_target	gene	0.60
CDKN1A	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDKN1B in their description or question text

No additional research found