concept

IL-17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

582Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IL-17
Key Genes/Proteins	Actin, Akt, AKT, AKT1, Alpha-Synuclein, ALZHEIMER
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    IL_17["IL-17"]
    IL_17 -->|"mediates"| Myeloid_Cell_Immune_Response["Myeloid Cell Immune Response"]
    IL_17 -->|"mediates"| Neuroinflammation["Neuroinflammation"]
    IL_17 -->|"promotes"| hidradenitis_suppurativa["hidradenitis suppurativa"]
    IL_17 -->|"co_expressed_with"| IL_1["IL-1"]
    IL_17 -.biomarker for.-> Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    IL_17 -->|"activates"| TNF["TNF"]
    IL_17 -->|"inhibits"| IL_6["IL-6"]
    Neutrophils["Neutrophils"] -->|"expressed in"| IL_17
    Microglia["Microglia"] -->|"expressed in"| IL_17
    APOPTOSIS["APOPTOSIS"] -->|"activates"| IL_17
    CYTOKINES["CYTOKINES"] -->|"inhibits"| IL_17
    CASP3["CASP3"] -->|"activates"| IL_17
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IL_17

Outgoing (341)

Target	Relation	Type	Str
Myeloid Cell Immune Response	mediates	process	0.85
Neuroinflammation	mediates	process	0.85
hidradenitis suppurativa	promotes	disease	0.85
Cognitive Impairment	associated_with	phenotype	0.85
IL-1	interacts_with	protein	0.80
Autoimmune Diseases	associated_with	disease	0.80
INFLAMMATION	associated_with	process	0.80
MICROGLIA	upregulates	cell_type	0.80
Rheumatoid Arthritis	biomarker_for	disease	0.80
skeletal muscle inflammation	mediates	process	0.70
Cirrhosis	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Vascular Dementia	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Als	expressed_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
IL-6	inhibits	gene	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ferroptosis	activates	disease	0.65
Stroke	expressed_in	disease	0.65
TNF	inhibits	gene	0.65
TNF	activates	gene	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Autoimmune	activates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	associated_with	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	regulates	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (241)

Source	Relation	Type	Str
Microglia	expressed_in	cell_type	0.85
Neutrophils	expressed_in	cell_type	0.85
TRIPTOLIDE	inhibits	compound	0.80
blood-brain barrier permeability	activates	process	0.70
TNF	causes	gene	0.60
TCR	regulates	gene	0.60
CXCL8	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
TNFR1	activates	gene	0.60
AND	inhibits	gene	0.60
IL-6	therapeutic_target	gene	0.60
BAD	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
NAD	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MLCK	activates	gene	0.60
CYP7B1	therapeutic_target	gene	0.60
GSH	therapeutic_target	gene	0.60
LCN2	activates	gene	0.60
CYP46A1	therapeutic_target	gene	0.60
SYP	inhibits	gene	0.60
PSME3	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
IL-1	associated_with	gene	0.60
IL-23	therapeutic_target	gene	0.60
IL-4	activates	gene	0.60
IL-22	inhibits	gene	0.60
P2RX7	activates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
CCL2	activates	gene	0.60
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60
TNF	transports	gene	0.60
RNA	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AMYLOID-BETA	activates	gene	0.60
CHI3L1	activates	gene	0.60
HBB	activates	gene	0.60
TNF-Α	inhibits	gene	0.60
IL1B	associated_with	gene	0.60
RNA	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
APOE	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
LAMP2	therapeutic_target	gene	0.60
TLR2	associated_with	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
MMP9	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to	0.640	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-17 in their description or question text

No additional research found