gene

ANXIETY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXIETY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2286Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ANXIETY is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 520 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ANXIETY
Morphology	immature neuron (source: Cell Ontology)
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	KETAMINE
Interactions	ACHE, Actin, AGING, AKT, Albumin, ALOX12
KG Connections	1337 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Bed Nucleus of Stria Terminalis in Anxiety

cell · 1168 words

→

Pathway Diagram

graph TD
    ANXIETY["ANXIETY"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    ANXIETY["ANXIETY"] -->|"activates"| Anxiety["Anxiety"]
    ANXIETY["ANXIETY"] -->|"activates"| ALS["ALS"]
    ANXIETY["ANXIETY"] -->|"activates"| Inflammation["Inflammation"]
    ANXIETY["ANXIETY"] -->|"associated"| Autism["Autism"]
    ANXIETY["ANXIETY"] -->|"associated"| Aging["Aging"]
    ASD["ASD"] -->|"causes"| ANXIETY["ANXIETY"]
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| ANXIETY["ANXIETY"]
    AMYLOID["AMYLOID"] -->|"associated"| ANXIETY["ANXIETY"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| ANXIETY["ANXIETY"]
    style ANXIETY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1157)

Target	Relation	Type	Str
Als	activates	disease	1.00
Anxiety	associated_with	disease	1.00
DEPRESSION	associated_with	gene	1.00
Depression	associated_with	disease	1.00
Anxiety	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Alzheimer's Disease	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Anxiety	activates	disease	0.95
DEPRESSION	interacts_with	disease	0.95
astrocytes	affects	cell_type	0.90
microglia	affects	cell_type	0.90
neurons	affects	cell_type	0.90
Hippocampal atrophy	promotes	phenotype	0.90
Oxidative Stress	activates	pathway	0.90
Oxidative Stress	activates	pathway	0.90
OXIDATIVE STRESS	activates	gene	0.90
Depression	causes	disease	0.85
Anxiety	causes	disease	0.85
Als	inhibits	disease	0.85
Inflammation	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Alzheimer	activates	disease	0.85
Depression	associated_with	disease	0.85
Alzheimer's Disease onset	causes	phenotype	0.84
Alzheimer's Disease	risk_factor_for	disease	0.82
cortex	affects	brain_region	0.80
amygdala	affects	brain_region	0.80
Cognitive Impairment	co_expressed_with	phenotype	0.80
hippocampus	affects	brain_region	0.80
GENES	activates	gene	0.80
ASTROCYTES	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
ASTROCYTE	activates	gene	0.80
DEPRESSION	causes	gene	0.80
Depression	activates	disease	0.75
Als	activates	disease	0.75
Alzheimer	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Parkinson	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Depression	expressed_in	disease	0.75
Parkinson	associated_with	disease	0.75
Als	associated_with	disease	0.75
ALS	activates	disease	0.75
Schizophrenia	associated_with	disease	0.75
Depression	therapeutic_target	disease	0.75
Aging	associated_with	disease	0.75
Autism	associated_with	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75

Incoming (1129)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	1.00
ANXIETY	inhibits	gene	1.00
DEPRESSION	associated_with	gene	1.00
ANXIETY	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ASTROCYTE	activates	gene	0.95
OXIDATIVE STRESS	activates	gene	0.95
ANXIETY	activates	gene	0.95
Stress	causes	process	0.95
Leukocytes	biomarker_for	biomarker	0.93
Alzheimer'S Disease	associated_with	disease	0.90
Serotonin	regulates	compound	0.90
Paro Robotic Pet	associated_with	entity	0.90
Reboxetine	treats	drug	0.90
ventral hippocampus to medial prefrontal cortex circuit	regulates	pathway	0.88
trigeminal neuralgia	causes	disease	0.85
NEUROINFLAMMATION	activates	gene	0.85
ASTROCYTES	activates	gene	0.85
GENES	activates	gene	0.85
DEPRESSION	causes	gene	0.85
ANXIETY	causes	gene	0.85
Circadian Dysregulation	causes	process	0.85
ALZHEIMER'S DISEASE	activates	gene	0.85
Pharmacogenetics	regulates	process	0.85
ALZHEIMER	activates	gene	0.85
BDNF	activates	gene	0.85
AADC Deficiency	causes	disease	0.80
Microbiota	associated_with	process	0.80
HCRTR2	modulates	gene	0.80
Gut Microbiota Dysbiosis	associated_with	process	0.80
CYP1A2	associated_with	gene	0.80
MICROGLIA	causes	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
DEPRESSION	inhibits	gene	0.75
COMPLEMENT	activates	gene	0.75
Als	activates	disease	0.75
BAX	activates	gene	0.75
PARKINSON	inhibits	gene	0.75
Als	therapeutic_target	disease	0.75
BCL-2	activates	gene	0.75
NF-ΚB	activates	gene	0.75
NEURODEGENERATION	inhibits	gene	0.75
CYTOKINES	associated_with	gene	0.75
DEMENTIA	inhibits	gene	0.75
PARKINSON'S DISEASE	inhibits	gene	0.75
ALZHEIMER'S DISEASE	associated_with	gene	0.75
SIRT1	activates	gene	0.75
INFLAMMATION	activates	gene	0.75
NRF2	activates	gene	0.75
CNO	inhibits	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity