concept

CALCIUM SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CALCIUM SIGNALING
Key Genes/Proteins	ADAM10, AMYLOID, AMYLOID-BETA, APOE, AQP4, BDNF
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcium Signaling Pathway in Neurodegeneration

mechanism · 3338 words

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Pathway Diagram

graph TD
    CALCIUM_SIGNALING["CALCIUM SIGNALING"]
    CALCIUM_SIGNALING -->|"interacts"| Phagocytosis["Phagocytosis"]
    CALCIUM_SIGNALING -->|"interacts"| Apoptosis["Apoptosis"]
    CALCIUM_SIGNALING -->|"interacts"| Akt["Akt"]
    CALCIUM_SIGNALING -->|"interacts"| Pi3K["Pi3K"]
    CALCIUM_SIGNALING -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    BCL2["BCL2"] -->|"regulates"| CALCIUM_SIGNALING
    JUN["JUN"] -->|"regulates"| CALCIUM_SIGNALING
    MCOLN1["MCOLN1"] -->|"regulates"| CALCIUM_SIGNALING
    BANG["BANG"] -->|"activates"| CALCIUM_SIGNALING
    GPR37["GPR37"] -->|"activates"| CALCIUM_SIGNALING
    GENES["GENES"] -->|"regulates"| CALCIUM_SIGNALING
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| CALCIUM_SIGNALING
    Als["Als"] -->|"regulates"| CALCIUM_SIGNALING
    Ms["Ms"] -->|"regulates"| CALCIUM_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| CALCIUM_SIGNALING

Outgoing (118)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Neuroregeneration	regulates	process	0.90
Macrophage Phagocytosis	mediates	process	0.90
mitochondrial function	regulates	process	0.85
Neuronal Cell Death	mediates	process	0.85
Neuronal Dendrites	involved_in	cell_type	0.80
neurons	active_in	cell_type	0.80
neural stem cells	active_in	cell_type	0.70
astrocytes	active_in	cell_type	0.70
synaptic plasticity	crosstalk_with	pathway	0.70
CDK5	regulates	gene	0.65
NEURODEGENERATION	treats	phenotype	0.65
INFLAMMATION	causes	phenotype	0.65
oligodendrocytes	active_in	cell_type	0.60
pericytes	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
hippocampus	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
microglia	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Fibroblast	regulates	cell_type	0.50
Microglia	activates	cell_type	0.50
Neutrophil	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Neutrophil	associated_with	cell_type	0.50
Dendritic Cell	associated_with	cell_type	0.50
Cardiomyocyte	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
ALZHEIMER'S	associated_with	concept	0.50
IL-17	expressed_in	concept	0.50
P2X7	associated_with	gene	0.50
NEURONS	associated_with	cell_type	0.50
PARKINSON'S	associated_with	concept	0.50
CASP3	associated_with	gene	0.50
VEGFA	associated_with	gene	0.50
TP53	associated_with	gene	0.50
TNF	associated_with	gene	0.50
IL6	associated_with	gene	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50

Incoming (492)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
Er-Plasma Membrane Junctions	mediates	mechanism	0.90
MAMs	mediates	process	0.90
GRIN1	mediates	gene	0.90
MERCS	regulates	process	0.90
ANNEXINS	involved_in	protein	0.90
APOE	inhibits	gene	0.90
ER-Mitochondria Contact Sites	involved_in	mechanism	0.90
ER-mitochondria distance	modulates	mechanism	0.90
P2 RECEPTORS	regulates	receptor	0.85
ER-Plasma Membrane Junctions	mediates	mechanism	0.85
APOE	associated_with	gene	0.85
PKC	participates_in	gene	0.85
NEUROGRANIN	activates	protein	0.80
Alzheimer's disease	involves	disease	0.80
neuroinflammation	involves	disease	0.80
Voltage-Gated Calcium Channels	regulates	protein	0.80
Als	regulates	disease	0.80
Alzheimer	therapeutic_target	disease	0.80
APOPTOSIS	therapeutic_target	gene	0.80
AQP4	involved_in	protein	0.75
GLUCOCORTICOID RECEPTOR	regulates	receptor	0.75
Rizzuto R	involved_in	protein	0.75
neurons	active_in	cell_type	0.75
BCL2	regulates	protein	0.70
Huntington's disease	involves	disease	0.70
NEURODEGENERATION	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
synaptic plasticity	mediates	pathway	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
MITOPHAGY	regulates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
Neurodegeneration	regulates	disease	0.70
LIPID PEROXIDATION	protects_against	phenotype	0.65
VEGFA	regulates	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
CASP3	regulates	gene	0.65
Inflammation	regulates	disease	0.65
NEURONS	regulates	cell_type	0.65
CREB	participates_in	gene	0.65
DRP1	treats	gene	0.60
VPS35	protects_against	gene	0.60
UCHL1	protects_against	gene	0.60
DNAJC6	protects_against	gene	0.60
CAT	interacts_with	gene	0.60
LRRK2	protects_against	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.632	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALCIUM SIGNALING in their description or question text

No additional research found