gene

NRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NRAS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Als, Cancer, Leukemia. Connected to 48 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRAS
Full Name	NRAS Proto-Oncogene, GTPase
Chromosome	1p13.2
Function	NRAS is a member of the Ras family of small GTPases that cycles between active GTP-bound and inactive GDP-bound states.
Primary Expression	the brain with high expression in the hippocampus, cortex, and cerebellum
Molecular Weight	21.2 kDa
Amino Acids	189 aa
Pathways	MAPK, PI3K, MAPK signaling
UniProt ID	P01111
Ensembl ID	ENSG00000213281
GeneCards	NRAS
Human Protein Atlas	NRAS
Brain	Neurons, astrocytes, and microglia
Skin	Melanocytes and keratinocytes
Immune System	T cells, B cells, and myeloid cells
Associated Diseases	Als, Cancer, epilepsy, Ms
Interactions	AKT, AKT3, AND, APC, BRAF, C1Q
KG Connections	167 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NRAS — AlphaFold P01111 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NRAS Gene

gene · 519 words

→

NRAS Protein

protein · 627 words

→

Pathway Diagram

graph TD
    NRAS["NRAS"]
    Ms{"Ms"}
    NRAS -->|"activates"| Ms
    Als{"Als"}
    NRAS -->|"activates"| Als
    Cancer{"Cancer"}
    NRAS -->|"therapeutic target"| Cancer
    Leukemia{"Leukemia"}
    NRAS -->|"therapeutic target"| Leukemia
    Synaptic_Plasticity(["Synaptic Plasticity"])
    NRAS -->|"activates"| Synaptic_Plasticity
    Complement(["Complement"])
    NRAS -->|"activates"| Complement
    Immune_Response(["Immune Response"])
    NRAS -->|"activates"| Immune_Response
    GENES["GENES"]
    NRAS -->|"activates"| GENES
    STAT1["STAT1"]
    NRAS -->|"activates"| STAT1
    PAI1["PAI1"]
    NRAS -->|"activates"| PAI1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NRAS -->|"activates"| NEURODEGENERATIVE_DISORDERS
    CANCER["CANCER"]
    NRAS -->|"therapeutic target"| CANCER
    C1Q["C1Q"]
    C1Q -->|"activates"| NRAS
    PAI1 -->|"activates"| NRAS
    TNF["TNF"]
    TNF -->|"activates"| NRAS
    STAT1 -->|"activates"| NRAS
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"activates"| NRAS
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"associated with"| NRAS
    NPM1["NPM1"]
    NPM1 -->|"associated with"| NRAS
    PER["PER"]
    PER -->|"therapeutic target"| NRAS
    TP53["TP53"]
    TP53 -->|"associated with"| NRAS
    TET2["TET2"]
    TET2 -->|"associated with"| NRAS
    DNMT3A["DNMT3A"]
    DNMT3A -->|"associated with"| NRAS
    style NRAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (96)

Target	Relation	Type	Str
cancer	risk_factor_for	disease	0.95
SHOC2	binds	protein	0.90
Cancer	associated_with	disease	0.90
Tumor	biomarker_for	disease	0.85
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Melanoma	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
PTEN	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
FGFR2	inhibits	gene	0.60
Mek	inhibits	protein	0.60
PIK3CA	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
epilepsy	associated_with	disease	0.60
PI3K	activates	gene	0.60
TP53	activates	gene	0.60
PTPN11	interacts_with	gene	0.60
PLCG1	associated_with	gene	0.60
TET2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
U2AF1	associated_with	gene	0.60
RAC1	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Complement	activates	pathway	0.60
Immune Response	activates	pathway	0.60
GENES	activates	gene	0.60
PAI1	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
RUNX1	associated_with	gene	0.60
Telomere	activates	pathway	0.60
MAPK	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
RAS	associated_with	gene	0.60
Synaptic Plasticity	associated_with	pathway	0.60

Incoming (71)

Source	Relation	Type	Str
RAS	associated_with	protein	0.70
HRAS	expressed_in	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
RAS FAMILY	expressed_in	gene	0.60
KRAS	associated_with	gene	0.60
AKT	activates	gene	0.60
APC	activates	gene	0.60
EGFR	activates	gene	0.60
HRAS	associated_with	gene	0.60
C1Q	activates	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60
TERT	activates	gene	0.60
BRAF	activates	gene	0.60
CDKN2A	activates	gene	0.60
TP53	activates	gene	0.60
NF1	activates	gene	0.60
CDK4	activates	gene	0.60
HRAS	therapeutic_target	gene	0.60
BRAF	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
NF1	interacts_with	gene	0.60
ATM	associated_with	gene	0.60
CDK6	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
PAI1	activates	gene	0.60
PER	therapeutic_target	gene	0.60
KRAS	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AND	expressed_in	gene	0.60
KRAS	causes	gene	0.60
RHEB	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
NF1	associated_with	gene	0.60
HRAS	causes	gene	0.60
NPM1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
TET2	associated_with	gene	0.60
DNMT3A	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRAS in their description or question text

No additional research found