protein 1,548 words KG: RAF1
Contents

c-Raf Protein (RAF1)

🔬 Protein Info
Gene SymbolRAF1
Full NameRAF1 proto-oncogene, serine/threonine kinase
Chromosome3p25.2
Protein TypeKinase
Functionencodes a 648-amino acid serine/threonine protein kinase with a molecular mass of approximately 72.
Primary Expressionbrain tissue
Amino Acids648 aa
PathwaysMAPK
UniProt ID[P04049](https://www.uniprot.org/uniprot/P04049)
Ensembl IDENSG00000132155
OMIM164760
GeneCardsRAF1
Human Protein AtlasRAF1
Associated DiseasesAls, Ms, Tumor
InteractionsACVR1, AKT, APOPTOSIS, CBL, CDC42, CREB
KG Connections167 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis in Neurodegeneration
entity · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
BCL2L1 Gene
gene · KG edge: associated_with
BIRC5 (Survivin)
gene · KG edge: therapeutic_target
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

E2F1 regulates RAF1
MYC regulates RAF1
DIABLO regulates RAF1
EGF activates RAF1
ERK1 activates RAF1
MDM2 activates RAF1
RAF1 regulates P38
RAF1 regulates DYRK1A
RAF1 regulates SMAC
RAF1 regulates AIF

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