gene

MAPK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

424Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAPK3 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 232 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK3
Full Name	Mitogen-Activated Protein Kinase 3
Aliases	Page for MAPK3 Gene
Chromosome	16p11.2
Protein Family	MAP kinase family, CMGC group
Protein Type	Kinase
Function	is a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular Localization	Cytoplasm, Nucleus
Molecular Weight	43 kDa
Amino Acids	379 aa
Pathways	MAPK, mapk
UniProt ID	P27361
GeneCards	MAPK3
Human Protein Atlas	MAPK3
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Cancer
Interactions	ACTB, Akt, AKT, AKT1, AND, APOPTOSIS
KG Connections	424 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAPK3 — AlphaFold P27361 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK3["MAPK3"]
    MAPK3 -->|"target for"| Cancer["Cancer"]
    MAPK3 -->|"target for"| Fibrosis["Fibrosis"]
    MAPK3 -->|"target for"| Als["Als"]
    MAPK3 -->|"target for"| Ms["Ms"]
    MAPK3 -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    MAPK3 -->|"expressed in"| Longevity["Longevity"]
    AKT["AKT"] -->|"target for"| MAPK3
    CASP3["CASP3"] -->|"target for"| MAPK3
    PI3K["PI3K"] -->|"target for"| MAPK3
    CD4["CD4"] -->|"interacts"| MAPK3
    TP53["TP53"] -->|"target for"| MAPK3
    AKT1["AKT1"] -->|"target for"| MAPK3
    TNF["TNF"] -->|"target for"| MAPK3
    IL_6["IL-6"] -->|"target for"| MAPK3
    CANCER["CANCER"] -->|"target for"| MAPK3
    APOPTOSIS["APOPTOSIS"] -->|"target for"| MAPK3

Outgoing (319)

Target	Relation	Type	Str
Mapk	therapeutic_target	pathway	1.00
Neurodegeneration	involved_in	process	0.90
Cytoplasm Localization	promotes	process	0.90
Atherosclerosis	associated_with	disease	0.90
Endoplasmic Reticulum Stress Response	mediates	process	0.88
TEAD	interacts_with	protein	0.85
Cancer-Related Signal Transduction	involved_in	pathway	0.85
Apoptosis	associated_with	process	0.85
TEAD1	regulates	protein	0.85
cell-matrix dissociation	promotes	process	0.82
suspension proficiency	drives	phenotype	0.81
MAPK signaling	participates_in	pathway	0.80
YAP1	modulates	protein	0.80
prostate injury	implicated_in	process	0.80
AKT	therapeutic_target	gene	0.80
EGFR	therapeutic_target	gene	0.80
Apoptosis	therapeutic_target	pathway	0.80
GENES	therapeutic_target	gene	0.80
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Mapk	associated_with	pathway	0.70
Mapk	activates	pathway	0.70
MMP9	therapeutic_target	gene	0.70
TP53	therapeutic_target	gene	0.70
CDKN1A	therapeutic_target	gene	0.70
MAPK1	associated_with	gene	0.70
MAPK1	activates	gene	0.70
HSP90AA1	therapeutic_target	gene	0.70
PI3K	targets	gene	0.70
AUTOPHAGY	therapeutic_target	gene	0.70
JUN	therapeutic_target	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
TNF	therapeutic_target	gene	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
MAPK1	therapeutic_target	gene	0.70
MYC	targets	gene	0.70
Autophagy	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Fibrosis	causes	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Hypertension	activates	disease	0.65
Inflammation	causes	disease	0.65
Aging	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65

Incoming (105)

Source	Relation	Type	Str
FGF2	activates	protein	0.90
Ros	activates	process	0.90
SBP	downregulates	drug	0.90
KDEL	activates	receptor	0.88
Shexiang Baoxin Pill	downregulates	drug	0.85
Cholix	upregulates	entity	0.85
PRKCD	associated_with	gene	0.80
Scutellarein	downregulates	compound	0.80
TNF	therapeutic_target	gene	0.70
PI3K	therapeutic_target	gene	0.70
CASP3	targets	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
FN1	interacts_with	gene	0.60
HIF	targets	gene	0.60
ERK1	activates	gene	0.60
ERK2	activates	gene	0.60
ERK1	associated_with	gene	0.60
TRIM16	implicated_in	gene	0.60
ERK2	associated_with	gene	0.60
BIRC5	therapeutic_target	gene	0.60
RAF1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
BCL2	targets	gene	0.60
MAPK1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
HRAS	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
BCL2	co_discussed	gene	0.60
CASP3	co_discussed	gene	0.60
AKT	co_discussed	gene	0.60
JAK2	co_discussed	gene	0.60
MAPK1	co_discussed	gene	0.60
FGF2	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HMOX1	regulates	gene	0.60
HSPA8	regulates	gene	0.60
JAK1	regulates	gene	0.60
JAK2	regulates	gene	0.60
MAPK1	regulates	gene	0.60
GSK3B	interacts_with	gene	0.60
IL-6	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
HRAS	targets	gene	0.60
HSP90AA1	targets	gene	0.60
ESR1	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK3 in their description or question text

No additional research found