concept

RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

30Hypotheses

5Analyses

0Outgoing

50Incoming

15Experiments

6Debates

Summary

RA is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 158 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RA
Key Genes/Proteins	A2M, ABCA1, ABCB1, ABCG1, ACTB, AGER
Linked Hypotheses	18 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RA["RA"]
    MAP1B["MAP1B"] -->|"implicated in"| RA
    MAP2["MAP2"] -->|"implicated in"| RA
    MAP6["MAP6"] -->|"implicated in"| RA
    GLUT4["GLUT4"] -->|"implicated in"| RA
    PPAR["PPAR"] -->|"implicated in"| RA
    RAB7A["RAB7A"] -->|"implicated in"| RA
    LRP2["LRP2"] -->|"implicated in"| RA
    ACTB["ACTB"] -->|"implicated in"| RA
    CTSD["CTSD"] -->|"implicated in"| RA
    ATG["ATG"] -->|"implicated in"| RA

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (158)

Source	Relation	Type	Str
RBP	associated_with	protein	0.56
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GBM	implicated_in	gene	0.50
C1QA	implicated_in	gene	0.50
C1QC	implicated_in	gene	0.50
C1Q	implicated_in	gene	0.50
SPI1	implicated_in	gene	0.50
UNC5B	implicated_in	gene	0.50
NTN1	implicated_in	gene	0.50
GPNMB	implicated_in	gene	0.50
NPTX2	implicated_in	gene	0.50
VGF	implicated_in	gene	0.50
PTN	implicated_in	gene	0.50
NTN3	implicated_in	gene	0.50
TARDBP	implicated_in	gene	0.50
SNRNP70	implicated_in	gene	0.50
AGER	implicated_in	gene	0.50
HSPA1A	implicated_in	gene	0.50
HSPA1B	implicated_in	gene	0.50
ERK1	implicated_in	gene	0.50
JNK	implicated_in	gene	0.50
STING	implicated_in	gene	0.50
IRF3	implicated_in	gene	0.50
IFN	implicated_in	gene	0.50
DOT1L	implicated_in	gene	0.50
PLCG2	implicated_in	gene	0.50
ABCB1	implicated_in	gene	0.50
PRMT5	implicated_in	gene	0.50
PRMT1	implicated_in	gene	0.50
PHGDH	implicated_in	gene	0.50
FASN	implicated_in	gene	0.50
EGR1	implicated_in	gene	0.50
KRAS	implicated_in	gene	0.50
G3BP1	implicated_in	gene	0.50
ALS	implicated_in	gene	0.50
TOLLIP	implicated_in	gene	0.50
NBR1	implicated_in	gene	0.50
FUS	implicated_in	gene	0.50
TRIM21	implicated_in	gene	0.50
OPTN	implicated_in	gene	0.50
NDP52	implicated_in	gene	0.50
BECN1	implicated_in	gene	0.50
TAX1BP1	implicated_in	gene	0.50
GFP	implicated_in	gene	0.50
SMCR8	implicated_in	gene	0.50
VCP	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.964	neuroscience	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.958	Alzheimer's disease	Circuit-level neural dynamics in neurode
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.907	neurodegeneration	What are the mechanisms by which gut mic

Gamma entrainment therapy to restore hippocampal-cortical sy	0.895	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
APOE-Dependent Autophagy Restoration	0.877	neurodegeneration	Survival Analysis of AD Patient Cohorts:
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.866	ALS	-
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular neurobiology	View
Glymphatic-Mediated Tau Clearance Dysfunction	0.865	neuroscience	Proteomics Differential Expression in AD
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Prima	0.862	neurodegeneration	Variant Annotation and Prioritization of
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.861	neuroscience	TREM2 in Alzheimer's Disease: Mechanisms
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.860	neurodegeneration	Perivascular spaces and glymphatic clear
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.858	ALS	-
H6: Aberrant eIF2α Phosphorylation Creates Stalled Translati	0.856	neurodegeneration	How do pathological stress granules tran
SFPQ Paralog Displacement Triggers Cryptic Polyadenylation a	0.850	ALS	-
Elevated CSF/Serum Albumin Quotient Predicts Neurodegenerati	0.850	-	What blood-brain barrier permeability ch
TBK1 Loss Locks Microglia in an Aged/Senescent Transcription	0.847	ALS	What are the mechanisms by which microgl
Beta-frequency entrainment therapy targeting PV interneuron-	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Neutral Sphingomyelinase-2 Inhibition for Synaptic Protectio	0.844	neurodegeneration	Lipid raft composition changes in synapt
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.842	ALS	-
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte	0.839	neurodegeneration	View
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	ALS	What are the mechanisms by which microgl
TBK1 Loss Triggers eIF2α-Mediated Translational Repression T	0.000	ALS	What are the mechanisms by which microgl

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-24 | 5 hypotheses Top: 0.790

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780

What amyloid threshold level is required for optimal clinical benefit in early A

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.577

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
iPSC-NPC effects on astrocytes in vitro ICH model	exploratory	intracerebral hemorrhage	0.900	0.00	in vitro ICH cell culture mode	completed	N/A
AMPK knockdown validation experiment	exploratory	intracerebral hemorrhage	0.880	0.00	astrocyte cell culture	proposed	N/A
P2RY12-MTOR pathway interaction in VSMCs	exploratory	atherosclerosis	0.850	0.00	cultured VSMCs	proposed	N/A
iPSC-NPC transplantation in ICH animal model	validation	intracerebral hemorrhage	0.850	0.00	animal ICH model	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	completed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253]	Koenig J, McGuire A, Homedan Y, Alberhas	eNeuro	2026	0
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800]	Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu	Molecular and cellular biochem	2026	0
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190]	Li J, Li J, Chen K	Mol Ther	2026	0
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169]	Li Z, Yang X, Mao J, Zeng P, Qi Y et al.	Autophagy	2026	0
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091]	Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a	Cancer Res	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635]	Huo R, Yang Y, Wei C, Yang Y, Meng D et	Int J Mol Med	2026	0
Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138]	Teng Z, Shahzad A, Xu Z, Xia J, Zhang J	J Hazard Mater	2026	0
Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999]	Usui N, Doi M, Berto S, Matsuoka K, Ishi	Sci Adv	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042]	Bellomo C, Furone F, Auricchio R, D'Anie	Sci Rep	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0
Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135]	Fang Y, Bai J, Bo S, Cui X, Song H, Guo	Frontiers in pharmacology	2026	0
Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823]	Alshaikh ABA, Al-Kuraishy HM, Abdelaziz	Naunyn-Schmiedeberg's archives	2026	0
Platelet proteomic signatures of amyloid β-positive mild cognitive impairment an [PMID:41904574]	Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Ro	Molecular brain	2026	0

Debates (6)

Multi-agent debates referencing this entity

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

closed · Rounds: 4 · Score: 0.80 · 2026-04-26

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

closed · Rounds: 4 · Score: 0.74 · 2026-04-24

While the study demonstrates dose-response relationships between amyloid levels

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning RA in their description or question text

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score: 0.895 · Alzheimer's disease · 2026-04-02

## Mechanistic Overview Gamma entrainment therapy to restore hippocampal-cortical synchrony starts from the claim that m

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Score: 0.892 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration starts from the claim that mod

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.887 · neurodegeneration · 2026-04-16

## Mechanistic Overview Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State

APOE-Dependent Autophagy Restoration

Score: 0.877 · neurodegeneration · 2026-04-02

## Mechanistic Overview APOE-Dependent Autophagy Restoration starts from the claim that modulating MTOR within the disea

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

Glymphatic-Mediated Tau Clearance Dysfunction

Score: 0.865 · neuroscience · 2026-04-07

## Mechanistic Overview Glymphatic-Mediated Tau Clearance Dysfunction starts from the claim that modulating MAPT within

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Score: 0.863 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a

TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Faile

Score: 0.862 · neurodegeneration · 2026-04-16

## Mechanistic Overview TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition

TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

Score: 0.861 · neuroscience · 2026-04-12

## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance starts from the claim

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

Score: 0.860 · neurodegeneration · 2026-04-02

## Mechanistic Overview Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation starts from the claim t

H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State

Score: 0.856 · neurodegeneration · 2026-04-22

## Mechanistic Overview H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State starts from the claim that

RA

Understanding Entity Pages

Summary

Wiki Pages (20)

TRA2B Protein - Transformer-2 Beta

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RAB9A

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

IL1RAP — Interleukin-1 receptor accessory protein

RAD21 — Cohesin Complex Component in Neurodegeneration

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RAN Translation in Neurodegeneration

RRAGB — Ras-Related GTP Binding B

RAB4B Gene

RAB35 — Ras-Associated Protein 35

RAB43 Gene

PILRA Gene

TRAIL Gene (TNFSF10)

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

RAB2A Gene

RABEP1

RAC1 Gene

Pathway Diagram

Outgoing (0)

Incoming (158)

Targeting Hypotheses (30)

Mentioning Analyses (5)

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

What amyloid threshold level is required for optimal clinical benefit in early A

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Experiments (15)

Related Papers (20)

Debates (6)

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

While the study demonstrates dose-response relationships between amyloid levels

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

Related Research

Gamma entrainment therapy to restore hippocampal-cortical synchrony

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

APOE-Dependent Autophagy Restoration

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Glymphatic-Mediated Tau Clearance Dysfunction

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Faile

TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State