gene

SLC16A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC16A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

378Connections
2Hypotheses
4Analyses
50Outgoing
50Incoming
0Experiments
4Debates

Summary

Page for SLC16A1 — Solute Carrier Family 16 Member 1 (Monocarboxylate Transporter 1)

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🧬 Gene Info
Gene SymbolSLC16A1
Full NameSolute Carrier Family 16 Member 1 (Monocarboxylate Transporter 1)
AliasesMonocarboxylate Transporter 1
Chromosome1p13.3
Protein TypeTransporter
Target ClassTransporter
FunctionTransporter modulation — restoring MCT1/MCT4 balance to normalize astrocyte-neuron metabolic coupling
Mechanism of ActionTransporter modulation — restoring MCT1/MCT4 balance to normalize astrocyte-neuron metabolic coupling
Primary Expressionbrain capillary endothelial cells forming the blood-brain barrier [7](https://pubmed
DruggabilityLow (0.38)
Clinical StagePhase II
Molecular Weight54 kDa
Amino Acids500 aa
PathwaysHistone Modification, Wnt
UniProt IDP53985
NCBI Gene ID6566
Ensembl IDENSG00000146411
OMIM109580
GeneCardsSLC16A1
Human Protein AtlasSLC16A1
Associated DiseasesAging, ALI, Als, alzheimer_s_disease, Alzheimer's Disease
Known Drugs/CompoundsATORVASTATIN, statins, TEMOZOLOMIDE
InteractionsActin, Akt, AKT, AMPK, AND, APOPTOSIS
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesDynamic Lactate-Pyruvate Ratio as Therapeutic Stra
Astrocyte MCT1/MCT4 Ratio Disruption with Metaboli
KG Connections378 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SLC16A1 — AlphaFold P53985 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC16A1 — Solute Carrier Family 16 Member 1 (Monocarboxylate Transporter 1)

gene · 1631 words

Pathway Diagram

graph TD
    SLC16A1["SLC16A1"]
    _middle_temporal_gyrus__spiny_L3["'middle temporal gyrus'_spiny_L3"]
    SLC16A1 -->|"expressed in"| _middle_temporal_gyrus__spiny_L3
    _middle_temporal_gyrus__aspiny_L3["'middle temporal gyrus'_aspiny_L3"]
    SLC16A1 -->|"expressed in"| _middle_temporal_gyrus__aspiny_L3
    _middle_temporal_gyrus__spiny_L5["'middle temporal gyrus'_spiny_L5"]
    SLC16A1 -->|"expressed in"| _middle_temporal_gyrus__spiny_L5
    Cancer{"Cancer"}
    SLC16A1 -->|"therapeutic target"| Cancer
    Ms{"Ms"}
    SLC16A1 -->|"therapeutic target"| Ms
    Cardiovascular{"Cardiovascular"}
    SLC16A1 -->|"inhibits"| Cardiovascular
    Als{"Als"}
    SLC16A1 -->|"inhibits"| Als
    Tumor{"Tumor"}
    SLC16A1 -->|"inhibits"| Tumor
    Hypertension{"Hypertension"}
    SLC16A1 -->|"inhibits"| Hypertension
    SLC16A1 -->|"associated with"| Ms
    SLC16A1 -->|"regulates"| Cancer
    SLC16A1 -->|"transports"| Cancer
    JUN["JUN"]
    JUN -->|"therapeutic target"| SLC16A1
    SLC16A2["SLC16A2"]
    SLC16A2 -->|"associated with"| SLC16A1
    SOD2["SOD2"]
    SOD2 -->|"associated with"| SLC16A1
    CAT["CAT"]
    CAT -->|"associated with"| SLC16A1
    BAX["BAX"]
    BAX -->|"associated with"| SLC16A1
    SPR["SPR"]
    SPR -->|"associated with"| SLC16A1
    PPARGC1A["PPARGC1A"]
    PPARGC1A -->|"associated with"| SLC16A1
    CASP3["CASP3"]
    CASP3 -->|"associated with"| SLC16A1
    PDK1["PDK1"]
    PDK1 -->|"associated with"| SLC16A1
    PDK4["PDK4"]
    PDK4 -->|"associated with"| SLC16A1
    SOD1["SOD1"]
    SOD1 -->|"associated with"| SLC16A1
    TNFR2["TNFR2"]
    TNFR2 -->|"associated with"| SLC16A1
    style SLC16A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (246)

TargetRelationTypeStr
MCT1encodesprotein1.00
THERAPEUTIC_TARGETtherapeutic_targetentity0.85
ENERGY METABOLISMinvolved_inentity0.85
T CELLexpressed_inentity0.80
SPERMATOGENESISinvolved_inentity0.80

Incoming (132)

SourceRelationTypeStr
h-seaad-v4-29e81bbctargetshypothesis0.90
RNAregulatesgene0.70
CD47interacts_withgene0.60
HMOX1interacts_withgene0.60
PI3Kactivatesgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification 0.677 translational neuroscience Which metabolic biomarkers can distingui
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli 0.668 Alzheimer's Disease Cell type vulnerability in Alzheimers Di

Mentioning Analyses (4)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.819

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] Jorstad NL, Close J, Johansen N, Yanny A Science 2023 186
Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based [PMID:40507957] Terzi A, Maqoud F, Guido D, Mallardi D, International journal of molec 2025 0
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation [PMID:39416192] Cluntun AA, Visker JR, Velasco-Silva JN, bioRxiv : the preprint server 2024 0
Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhib [PMID:36584238] Puri S, Stefan K, Khan SL, Pahnke J, Ste Journal of medicinal chemistry 2023 0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] Wieschollek S, Forster S, Megerle K Handchirurgie, Mikrochirurgie, 2022 0
SLC gene mutations and pediatric neurological disorders: diverse clinical phenot [PMID:34797406] Mir A, Almudhry M, Alghamdi F, Albaradie Human genetics 2022 0
Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptak [PMID:35177691] Hascup ER, Sime LN, Peck MR, Hascup KN Scientific reports 2022 0
Editor's Review and Introduction: Cognition-Inspired Artificial Intelligence. [PMID:35853452] Cassenti DN, Veksler VD, Ritter FE Topics in cognitive science 2022 0
Innovations in systemic sclerosis. [PMID:34483059] Sindhu R Johnson Best practice & research. 2021 0
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration [PMID:34491913] Jha MK, Passero JV, Rawat A, Ament XH, Y The Journal of clinical invest 2021 0
Genome sequencing analysis identifies new loci associated with Lewy body dementi [PMID:33589841] Chia R, Sabir MS, Bandres-Ciga S, Saez-A Nature genetics 2021 0
Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] Yadav P, Antony-Babu S, Hayes E, Healy O Microbiology resource announce 2021 0
Engineering complex communities by directed evolution. [PMID:33986540] Chang CY, Vila JCC, Bender M, Li R, Mank Nature ecology & evolution 2021 0
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] Tajika T, Kuboi T, Endo F, Hatori Y, Sai Progress in rehabilitation med 2021 0
Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibi [PMID:31605138] Avitabile M, Succoio M, Testori A, Cardi Carcinogenesis 2020 0
Manassantin B shows antiviral activity against coxsackievirus B3 infection by ac [PMID:31253850] Song JH, Ahn JH, Kim SR, Cho S, Hong EH, Scientific reports 2019 0
Brain Glucose Metabolism: Integration of Energetics with Function. [PMID:30565508] Dienel GA Physiological reviews 2019 0
A ketogenic drink improves brain energy and some measures of cognition in mild c [PMID:31027873] Fortier M, Castellano CA, Croteau E, Lan Alzheimer's & dementia : the j 2019 0
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms an [PMID:28778403] Koschmieder S, Vetrie D Seminars in cancer biology 2018 0
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, [PMID:29752860] Thomson PJ Journal of oral pathology & me 2018 0

Debates (4)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

closed · Rounds: 3 · Score: 0.68 · 2026-04-02

Related Research

Hypotheses and analyses mentioning SLC16A1 in their description or question text

No additional research found