gene

DNAJB6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

471Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

DNAJB6 gene involved in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DNAJB6
Chromosome	7p12.3
Protein Type	Chaperone
Target Class	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Primary Expression	Broad, high in muscle and brain
Druggability	Undruggable (0.23)
Molecular Weight	38 kDa
Amino Acids	326 aa
Pathways	proteostasis
UniProt ID	O75146
GeneCards	DNAJB6
Human Protein Atlas	DNAJB6
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
Known Drugs/Compounds	amyloid-beta 42
Interactions	Actin, alpha-synuclein, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALS, ALZHEIMER
SciDEX Target	View Target Profile
SciDEX Hypotheses	HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding
KG Connections	471 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJB6 — AlphaFold O75146 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNAJB6 Gene

gene · 584 words

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DNAJB6 Protein

protein · 1572 words

→

Pathway Diagram

graph TD
    DNAJB6["DNAJB6"]
    Myofibrillar_Myopathy{"Myofibrillar Myopathy"}
    DNAJB6 -->|"causes"| Myofibrillar_Myopathy
    FLNC["FLNC"]
    DNAJB6 -->|"degrades"| FLNC
    MYOT["MYOT"]
    DNAJB6 -->|"degrades"| MYOT
    NBR1["NBR1"]
    DNAJB6 -->|"degrades"| NBR1
    P62["P62"]
    DNAJB6 -->|"degrades"| P62
    SQSTM1["SQSTM1"]
    DNAJB6 -->|"degrades"| SQSTM1
    HSP70("HSP70")
    DNAJB6 -->|"interacts_with"| HSP70
    alpha_synuclein("alpha-synuclein")
    DNAJB6 -->|"inhibits"| alpha_synuclein
    amyloid_beta("amyloid-beta")
    DNAJB6 -->|"inhibits"| amyloid_beta
    LGMDD1{"LGMDD1"}
    DNAJB6 -->|"associated_with"| LGMDD1
    Parkinson_s_disease{"Parkinson's disease"}
    DNAJB6 -->|"protects_against"| Parkinson_s_disease
    Alzheimer_s_disease{"Alzheimer's disease"}
    DNAJB6 -->|"protects_against"| Alzheimer_s_disease
    proteostasis(["proteostasis"])
    DNAJB6 -->|"involved_in"| proteostasis
    hnRNPA2B1("hnRNPA2B1")
    DNAJB6 -->|"interacts_with"| hnRNPA2B1
    FUS("FUS")
    DNAJB6 -->|"modulates"| FUS

Outgoing (360)

Target	Relation	Type	Str
FUS condensates	inhibits	mechanism	0.95
Hsp70	interacts_with	protein	0.95
LGMDD1	causes	disease	0.95
Hsp70	binds	protein	0.95
Myofibrillar Myopathy	causes	disease	0.95
Amyloid Protein Aggregation	suppresses	process	0.95
phase separation	regulates	process	0.93
FUS fibrilization	inhibits	process	0.92
Amyloid Proteins	inhibits	protein	0.90
Protein Aggregation	inhibits	process	0.90
Myofibrillar Degeneration	causes	phenotype	0.90
Hsp70	activates	protein	0.90
Alpha-Synuclein	suppresses	protein	0.90
Neurodegeneration	protects_against	process	0.90
Alzheimer'S Disease	protects_against	disease	0.85
Parkinson'S Disease	protects_against	disease	0.85
Proteostasis	regulates	process	0.85
Polyglutamine-Expanded Proteins	inhibits	protein	0.85
LGMDD1	therapeutic_target	disease	0.85
oxidative stress response	participates_in	pathway	0.80
Huntington's disease	prevents	disease	0.80
Alzheimer's disease	blocks	disease	0.80
Synucleinopathies	protects_against	disease	0.80
Tauopathies	protects_against	disease	0.80
amyloid-beta 42	inhibits	compound	0.80
TAU	regulates	protein	0.80
Huntington'S Disease	protects_against	disease	0.80
neurons	activates	cell_type	0.70
Alzheimer's disease	inhibits	disease	0.70
Huntington's disease	inhibits	disease	0.70
Alzheimer's disease	implicated_in	disease	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
neurons	protects_against	cell_type	0.70
neurodegeneration	inhibits	disease	0.70
Neuropathy	inhibits	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Spinal Muscular Atrophy	inhibits	disease	0.65
ALS	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ataxia	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Bipolar	regulates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	stabilizes	disease	0.65
Neuropathy	stabilizes	disease	0.65
Huntington	stabilizes	disease	0.65
Parkinson	stabilizes	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	regulates	disease	0.65

Incoming (111)

Source	Relation	Type	Str
h-c9486869	targets_gene	hypothesis	0.90
HNRNPA2B1	genetically_interacts	gene	0.80
NEURODEGENERATION	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
PARKINSON	stabilizes	gene	0.60
CHMP4B	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
DES	associated_with	gene	0.60
P62	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
MYOT	associated_with	gene	0.60
FLNC	associated_with	gene	0.60
DNAJB1	suppresses	gene	0.60
DNAJB1	expressed_in	gene	0.60
DNAJB1	degrades	gene	0.60
DNAJA1	inhibits	gene	0.60
HUNTINGTON	stabilizes	gene	0.60
GSK3	inhibits	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
MICROGLIA	activates	gene	0.60
NEURON	activates	gene	0.60
AND	regulates	gene	0.60
GENES	inhibits	gene	0.60
AND	inhibits	gene	0.60
GENES	causes	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DEMENTIA	associated_with	gene	0.60
AND	interacts_with	gene	0.60
NEUROTOXICITY	inhibits	gene	0.60
DES	degrades	entity	0.60
HSP70	interacts_with	gene	0.60
GAIN	interacts_with	gene	0.60
DNAJB1	stabilizes	gene	0.60
HSP70	stabilizes	gene	0.60
DNAJA1	stabilizes	gene	0.60
DNAJB2	stabilizes	gene	0.60
GAIN	activates	gene	0.60
BRCA1	degrades	entity	0.60
PPP2CB	interacts_with	gene	0.60
DCTN1	regulates	gene	0.60
DYNACTIN	regulates	gene	0.60
DYNEIN	regulates	gene	0.60
POLE	regulates	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
HUNTINGTIN	interacts_with	gene	0.60
FUS	activates	gene	0.60
HDAC4	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

neurodegeneration | 2026-04-12 | 0 hypotheses

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025
Extracellular chaperone networks and the export of J-domain proteins. [PMID:36581212]	Braun JEA	The Journal of biological chem	2023
DNAJB6 mutants display toxic gain of function through unregulated interaction wi [PMID:37923706]	Abayev-Avraham M, Salzberg Y, Gliksberg	Nature communications	2023
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuc [PMID:36302971]	Kuiper EFE, Gallardo P, Bergsma T, Mari	Nature cell biology	2022
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An Inte [PMID:34602496]	Megarbane A, Bizzari S, Deepthi A, Sabba	Journal of neuromuscular disea	2022
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkin [PMID:34390836]	["Arkan S", "Ljungberg M", "Kirik D", "H	Neurobiology of disease	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021
Panorama of the distal myopathies. [PMID:33458580]	Savarese M, Sarparanta J, Vihola A, Jons	Acta myologica : myopathies an	2020
Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395]	Wiltshire T, Ducy M, Foo TK, Hu C, Lee K	Genetics in medicine : officia	2020
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. [PMID:32268123]	["Thiruvalluvan A", "de Mattos E", "Brun	Molecular cell	2020
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment [PMID:30737131]	Merlini M, Rafalski VA, Rios Coronado PE	Neuron	2019
Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 [PMID:30564623]	Nallamilli BRR, Chakravorty S, Kesari A,	Annals of clinical and transla	2018
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. [PMID:27276715]	Meng E, Shevde LA, Samant RS	Oncotarget	2016

Debates (3)

Multi-agent debates referencing this entity

The debate revealed that DNAJB6 evidence is limited to polyglutamine aggregation

closed · Rounds: 4 · Score: 0.79 · 2026-04-16

Protein aggregation cross-seeding across neurodegenerative diseases?

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.53 · 2026-04-06