gene

SYNJ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

1Hypotheses

0Analyses

30Outgoing

50Incoming

0Experiments

0Debates

Summary

SYNJ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Als, Ms. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SYNJ1
Full Name	Synaptojanin 1
Chromosome	21q22.11
Protein Type	Phosphatase
Function	SYNJ1 is crucial for synaptic vesicle cycling
Molecular Weight	165 kDa
Amino Acids	428 aa
Exons	31
Pathways	Endosomal Sorting
UniProt ID	SYNJ1
GeneCards	SYNJ1
Human Protein Atlas	SYNJ1
Associated Diseases	Als, Cancer, Ms, Parkinson
Interactions	AD, ATP13A2, BIN1, DJ1, DNAJC6, FBXO7
KG Connections	119 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYNJ1["SYNJ1"]
    Parkinson{"Parkinson"}
    SYNJ1 -->|"associated with"| Parkinson
    Als{"Als"}
    SYNJ1 -->|"associated with"| Als
    Ms{"Ms"}
    SYNJ1 -->|"associated with"| Ms
    SYNJ1 -->|"therapeutic target"| Als
    Aging{"Aging"}
    SYNJ1 -->|"therapeutic target"| Aging
    Autophagy(["Autophagy"])
    SYNJ1 -->|"associated with"| Autophagy
    AUTOPHAGY["AUTOPHAGY"]
    SYNJ1 -->|"associated with"| AUTOPHAGY
    DNAJC6["DNAJC6"]
    SYNJ1 -->|"associated with"| DNAJC6
    GENE_MUTATIONS["GENE MUTATIONS"]
    SYNJ1 -->|"associated with"| GENE_MUTATIONS
    PARK2["PARK2"]
    SYNJ1 -->|"associated with"| PARK2
    Endocytosis(["Endocytosis"])
    SYNJ1 -->|"associated with"| Endocytosis
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    SYNJ1 -->|"therapeutic target"| MITOCHONDRIAL_DYSFUNCTION
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SYNJ1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| SYNJ1
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| SYNJ1
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| SYNJ1
    INPP5F["INPP5F"]
    INPP5F -->|"associated with"| SYNJ1
    GAK["GAK"]
    GAK -->|"associated with"| SYNJ1
    AGING["AGING"]
    AGING -->|"therapeutic target"| SYNJ1
    FLAVONOIDS["FLAVONOIDS"]
    FLAVONOIDS -->|"therapeutic target"| SYNJ1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic target"| SYNJ1
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"therapeutic target"| SYNJ1
    GENES["GENES"]
    GENES -->|"associated with"| SYNJ1
    MITOCHONDRIAL_DYSFUNCTION -->|"therapeutic target"| SYNJ1
    style SYNJ1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
VPS35	interacts_with	gene	0.95
Endosomal Sorting	regulates	process	0.90
Parkinson's Disease	risk_factor_for	disease	0.90
Dopamine Release	modulates	process	0.85
VPS13C	interacts_with	gene	0.70
Cancer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
PARK2	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
Ras	expressed_in	protein	0.60
Akt	expressed_in	protein	0.60
Mtor	expressed_in	pathway	0.60
VPS13C	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
Autophagy	associated_with	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Endocytosis	associated_with	pathway	0.60
neurons	expressed_in	cell_type	0.60
DNAJC6	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
TAU	co_discussed	gene	0.40
VPS35	co_discussed	gene	0.40

Incoming (89)

Source	Relation	Type	Str
ATP13A2	interacts_with	gene	0.80
DNAJC6	interacts_with	gene	0.80
FBXO7	interacts_with	gene	0.80
PRKN	interacts_with	gene	0.80
PINK1	interacts_with	gene	0.80
PARK7	associated_with	gene	0.70
SNCA	causes	gene	0.70
PLA2G6	associated_with	gene	0.70
DOPAMINERGIC	associated_with	cell_type	0.70
FBXO7	associated_with	gene	0.70
GBA	associated_with	gene	0.70
BIN1	activates	gene	0.70
PARK7	interacts_with	gene	0.70
LRRK2	interacts_with	gene	0.70
SNCA	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.60
APOE	regulates	gene	0.60
ATP13A2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
STING	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
SH3GL2	associated_with	gene	0.60
ROS	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
PD	associated_with	gene	0.60
PD	causes	gene	0.60
PD	co_discussed	gene	0.60
NEURON	activates	cell_type	0.60
AD	associated_with	gene	0.60
AD	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	disease	0.60
AD	expresses	gene	0.60
AD	co_discussed	gene	0.60
NEURON	co_discussed	cell_type	0.60
AD	regulates	gene	0.60
AD	degrades	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SYNJ1 Aggregation and Solubility Loss Impairs PI(4,5)P2 Cycl	0.621	neurodegeneration	What are the specific PTM changes in syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNJ1 in their description or question text

No additional research found