gene

UBQLN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBQLN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

179Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UBQLN2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 63 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UBQLN2
Full Name	Ubiquilin 2
Protein Family	Ubiquilin family
Function	Contains disease-causing mutations (P497H, P506T)
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	66 kDa
Amino Acids	600 aa
Exons	11
Pathways	Protein Degradation
UniProt ID	Q9R0R5
GeneCards	UBQLN2
Human Protein Atlas	UBQLN2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, frontotemporal dementia, FTLD, Ms
Interactions	26S Proteasome, AGING, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, APP
KG Connections	179 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: UBQLN2 — AlphaFold Q9R0R5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UBQLN2["UBQLN2"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    UBQLN2 -->|"associated with"| OXIDATIVE_STRESS
    PROTEIN_DEGRADATION(["PROTEIN_DEGRADATION"])
    UBQLN2 -->|"activates"| PROTEIN_DEGRADATION
    ALS{"ALS"}
    UBQLN2 -->|"associated with"| ALS
    HSP70["HSP70"]
    UBQLN2 -->|"interacts with"| HSP70
    UNC5B["UNC5B"]
    UBQLN2 -->|"interacts with"| UNC5B
    Neurodegeneration{"Neurodegeneration"}
    UBQLN2 -->|"therapeutic target"| Neurodegeneration
    Aging{"Aging"}
    UBQLN2 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    UBQLN2 -->|"associated with"| Ms
    Als{"Als"}
    UBQLN2 -->|"therapeutic target"| Als
    UBQLN2 -->|"associated with"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    UBQLN2 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    UBQLN2 -->|"activates"| Neurodegeneration
    FUS["FUS"]
    FUS -->|"associated with"| UBQLN2
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"activates"| UBQLN2
    OXIDATIVE_STRESS -->|"associated with"| UBQLN2
    AND["AND"]
    AND -->|"activates"| UBQLN2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| UBQLN2
    ALS -->|"activates"| UBQLN2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| UBQLN2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| UBQLN2
    AGING["AGING"]
    AGING -->|"activates"| UBQLN2
    style UBQLN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (99)

Target	Relation	Type	Str
Ubiquitin	interacts_with	protein	0.95
Protein Degradation	involved_in	process	0.90
26S Proteasome	interacts_with	protein	0.90
Oxidative Stress	protects_against	process	0.90
Phase Separation	involved_in	process	0.85
Parkin	interacts_with	gene	0.80
PHB2	interacts_with	gene	0.80
FTLD	implicated_in	disease	0.80
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
Neurodegeneration	activates	disease	0.75
ALS	associated_with	disease	0.72
PROTEIN_DEGRADATION	activates	pathway	0.72
UNC5B	interacts_with	gene	0.70
HSP70	interacts_with	protein	0.70
MOTOR NEURONS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
TDP-43	phosphorylates	gene	0.65
MOTOR NEURONS	regulates	cell_type	0.65
NEURODEGENERATION	regulates	disease	0.65
NEURODEGENERATION	causes	disease	0.65
MOTOR NEURONS	produces	cell_type	0.65
STRESS GRANULES	recruits	phenotype	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
OPTN	activates	gene	0.65
Aging	activates	disease	0.65
Prion	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
UBIQUITIN	causes	protein	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
C9orf72	exacerbates	gene	0.65
OXIDATIVE_STRESS	inhibits	phenotype	0.64
HSP70	inhibits	gene	0.60
TDP-43	activates	gene	0.60
Rb	associated_with	protein	0.60
VCP	implicated_in	gene	0.60
ULK1	regulates	gene	0.60
ULK1	associated_with	gene	0.60
VAPB	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
VCP	causes	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
GENES	associated_with	gene	0.60

Incoming (80)

Source	Relation	Type	Str
Ubiquitylation	regulates	process	0.95
Ubl Domain	protects_against	protein	0.90
E6AP	degrades	protein	0.85
HSP70	interacts_with	gene	0.80
Ubiquitin	upregulates	protein	0.80
FTD	associated_with	disease	0.80
OPTN	interacts_with	gene	0.70
UBIQUITIN	activates	protein	0.65
APP	interacts_with	gene	0.65
TDP-43	exacerbates	gene	0.65
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALS	interacts_with	gene	0.60
ALS	regulates	gene	0.60
ALS	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
ALS	targets	entity	0.60
UBIQUITIN	associated_with	gene	0.60
C9ORF72	inhibits	gene	0.60
UBIQUITIN	protects_against	entity	0.60
C9ORF72	associated_with	gene	0.60
TDP-43	activates	gene	0.60
TARDBP	implicated_in	gene	0.60
BAG6	activates	gene	0.60
BAG6	inhibits	gene	0.60
BAG6	implicated_in	gene	0.60
BAG6	interacts_with	gene	0.60
ATG5	regulates	gene	0.60
LC3	regulates	gene	0.60
ATG5	associated_with	gene	0.60
LC3	associated_with	gene	0.60
HSP70	expressed_in	gene	0.60
FUS	interacts_with	gene	0.60
ANXA11	causes	gene	0.60
CCNF	causes	gene	0.60
CHCHD10	causes	gene	0.60
CHCHD2	causes	gene	0.60
CHMP2B	causes	gene	0.60
CYLD	causes	gene	0.60
FUS	causes	gene	0.60
GRN	causes	gene	0.60
MAPT	causes	gene	0.60
OPTN	causes	gene	0.60
PRNP	causes	gene	0.60
SIGMAR1	causes	gene	0.60
SQSTM1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBQLN2 in their description or question text

No additional research found