concept

NEUROBLASTOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROBLASTOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

425Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NEUROBLASTOMA is a concept in neurodegeneration research. Key relationships include: interacts with, activates, co discussed. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA. Connected to 21 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NEUROBLASTOMA
Key Genes/Proteins	ACHE, AD, ADAM10, ADAM17, ALK, ALS
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	APOPTOSIS

Pathway Diagram

graph TD
    NEUROBLASTOMA["NEUROBLASTOMA"]
    NEUROBLASTOMA -->|"activates"| P62["P62"]
    NEUROBLASTOMA -->|"activates"| SOD1["SOD1"]
    NEUROBLASTOMA -->|"activates"| SQSTM1["SQSTM1"]
    NEUROBLASTOMA -->|"activates"| TARDBP["TARDBP"]
    NEUROBLASTOMA -->|"activates"| TFEB["TFEB"]
    NEUROBLASTOMA -->|"expressed in"| SENESCENCE["SENESCENCE"]
    NEUROBLASTOMA -->|"promotes"| NEURON["NEURON"]
    ATG10["ATG10"] -->|"activates"| NEUROBLASTOMA
    ATG12["ATG12"] -->|"activates"| NEUROBLASTOMA
    CALCINEURIN["CALCINEURIN"] -->|"activates"| NEUROBLASTOMA
    C9ORF72["C9ORF72"] -->|"interacts"| NEUROBLASTOMA
    RAB7L1["RAB7L1"] -->|"interacts"| NEUROBLASTOMA
    FAM38A["FAM38A"] -->|"activates"| NEUROBLASTOMA
    FAM38B["FAM38B"] -->|"activates"| NEUROBLASTOMA
    PIEZO1["PIEZO1"] -->|"activates"| NEUROBLASTOMA
    PIEZO2["PIEZO2"] -->|"activates"| NEUROBLASTOMA
    ALS["ALS"] -->|"interacts"| NEUROBLASTOMA
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| NEUROBLASTOMA
    ATAXIA["ATAXIA"] -->|"activates"| NEUROBLASTOMA

Outgoing (146)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.85
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Pi3K/Akt	therapeutic_target	pathway	0.70
Mitophagy	activates	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Autophagy	activates	pathway	0.70
PARKIN	produces	gene	0.65
AMYLOID	treats	protein	0.65
PARKIN	modifies	gene	0.65
Alzheimer	activates	disease	0.65
PINK1	causes	gene	0.65
Tumor	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
STING	biomarker_for	gene	0.65
NEURONS	processes	cell_type	0.65
DOPAMINE	inhibits	phenotype	0.65
Parkinson	associated_with	disease	0.65
CHRNA7	protects_against	gene	0.65
TDP-43	protects_against	gene	0.60
SOD1	activates	gene	0.60
TREM2	enhances	gene	0.60
NEURON	promotes	cell_type	0.60
Stem Cell	associated_with	pathway	0.60
NEURON	expressed_in	cell_type	0.60
Differentiation	associated_with	pathway	0.60
Dna Methylation	protects_against	pathway	0.60
NEURONS	expresses	cell_type	0.60
Epigenetic	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Receptor Tyrosine Kinase	inhibits	pathway	0.60
TARDBP	activates	gene	0.60
Senescence	activates	pathway	0.60
Mtor	activates	pathway	0.60
Differentiation	biomarker_for	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
SQSTM1	activates	gene	0.60
Epigenetic	protects_against	pathway	0.60
Immune Checkpoint	inhibits	pathway	0.60
P62	activates	gene	0.60
Stem Cell	activates	pathway	0.60
TFEB	activates	gene	0.60
Metastasis	therapeutic_target	pathway	0.60
Nf-Kb	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60

Incoming (279)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.95
ALZHEIMER'S DISEASE	activates	gene	0.75
AUTOPHAGY	activates	gene	0.75
MITOPHAGY	activates	gene	0.75
GENES	activates	gene	0.75
AKT	therapeutic_target	gene	0.75
PI3K	therapeutic_target	gene	0.75
MTOR	therapeutic_target	gene	0.75
LC3	activates	gene	0.75
ALZHEIMER	activates	gene	0.75
CANCER	therapeutic_target	gene	0.75
CANCER	activates	gene	0.75
PARKINSON	associated_with	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
ROS	activates	gene	0.75
PI3K	activates	gene	0.65
JUN	activates	gene	0.65
JNK	activates	gene	0.65
NF-KB	activates	gene	0.65
TNF-Α	activates	gene	0.65
BCL-2	activates	gene	0.65
AKT	activates	gene	0.65
NEUROINFLAMMATION	activates	gene	0.65
NEURODEGENERATION	inhibits	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65
ALPHA-SYNUCLEIN	inhibits	gene	0.65
BAX	biomarker_for	gene	0.65
CREB	biomarker_for	gene	0.65
BIRC5	therapeutic_target	gene	0.65
PHOX2B	therapeutic_target	gene	0.65
RAS	therapeutic_target	gene	0.65
CANCER	associated_with	gene	0.65
MDM2	therapeutic_target	gene	0.65
OVERVIEW	therapeutic_target	gene	0.65
BAX	activates	gene	0.65
TNF	activates	gene	0.65
NEURODEGENERATIVE DISEASES	associated_with	gene	0.65
ALS	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
DNA	associated_with	gene	0.65
BECN1	activates	gene	0.65
NEUROTOXICITY	activates	gene	0.65
LYSOSOME	activates	gene	0.65
MAP1LC3	activates	gene	0.65
P62	activates	gene	0.65
SQSTM1	activates	gene	0.65
MTOR	activates	gene	0.65
APOPTOSIS	biomarker_for	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROBLASTOMA in their description or question text

No additional research found